Abstract
Ibopamine stimulates α-adrenergic receptors and D1-dopaminergic receptors in the eye. Ibopamine is a dopamine analogue and it is hydrolysed to epinine by the esterases in the aqueous humor. Adrenergic stimulation determines the non-cycloplegic mydriatic effect, while the D1-dopaminergic activity is responsible for an increase in aqueous humor production. Ibopamine is effective as a mydriatic before and after surgical procedures. Its main uses are: provocative test in glaucoma; treatment of ocular hypotony; evaluation of the outflow pathways of the aqueous humor. Ibopamine test is positive in 92% of patients affected by primary open-angle glaucoma (POAG), while it is negative in healthy eyes. It is useful in relatives of glaucomatous patients.
Keywords: Ibopamine, dopaminergic drugs, non-cycloplegic mydriatic, glaucoma, diagnostic test, ocular hypotony
Current Drug Therapy
Title: Ibopamine Stimulates α-Adrenergic Receptors and D1 Dopaminergic Receptors in the Eye
Volume: 2 Issue: 2
Author(s): Italo Giuffre
Affiliation:
Keywords: Ibopamine, dopaminergic drugs, non-cycloplegic mydriatic, glaucoma, diagnostic test, ocular hypotony
Abstract: Ibopamine stimulates α-adrenergic receptors and D1-dopaminergic receptors in the eye. Ibopamine is a dopamine analogue and it is hydrolysed to epinine by the esterases in the aqueous humor. Adrenergic stimulation determines the non-cycloplegic mydriatic effect, while the D1-dopaminergic activity is responsible for an increase in aqueous humor production. Ibopamine is effective as a mydriatic before and after surgical procedures. Its main uses are: provocative test in glaucoma; treatment of ocular hypotony; evaluation of the outflow pathways of the aqueous humor. Ibopamine test is positive in 92% of patients affected by primary open-angle glaucoma (POAG), while it is negative in healthy eyes. It is useful in relatives of glaucomatous patients.
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Cite this article as:
Giuffre Italo, Ibopamine Stimulates α-Adrenergic Receptors and D1 Dopaminergic Receptors in the Eye, Current Drug Therapy 2007; 2 (2) . https://dx.doi.org/10.2174/157488507780619112
DOI https://dx.doi.org/10.2174/157488507780619112 |
Print ISSN 1574-8855 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3903 |
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