Abstract
Purpose of review: The mortality of type 2 diabetic patients with renal disease is high during both the pre-dialysis period as well as the period under dialysis therapy. With respect to rare data in the literature it may be assumed that the mortality rate is especially high during the last year before and the first year after start of dialysis therapy. Recent findings: After reviewing the reports in the literature dealing with survival of diabetic patients with nephropathy it may be concluded that mortality is especially high during the year before and after initiating dialysis. There are exact survival data of type 2 diabetic patients under dialysis therapy but only few data concerning the survival during the last year prior to dialysis treatment. The possible reasons for this higher mortality shortly before and after start of dialysis are discussed in this article. Summary: The mortality in type 2 diabetic patients is especially high during the last year before and the first year after the start of dialysis therapy. However, only the higher mortality during the first year after initiating dialysis is well documented in the literature. Those patients who die early within 90 days of dialysis are not registered in the registries, therefore, the overall mortality during the first dialysis year is at least 5% higher than the registered. uring both periods several factors may play a causal role in the high mortality, a higher prevalence of heart failure, and a progression of macroangiopathy with higher incidence of cardiovascular events due to traditional and non-traditional risk factors, especially inflammation and oxidative stress.
Keywords: Type 2-diabetes, Renal failure, Mortality, Pre-dialysis period, Dialysis
Current Diabetes Reviews
Title: Highest Mortality During the Last Year Before and the First Year After Start of Dialysis Treatment in Type 2 Diabetic Patients with Nephropathy
Volume: 3 Issue: 2
Author(s): Georg Biesenbach
Affiliation:
Keywords: Type 2-diabetes, Renal failure, Mortality, Pre-dialysis period, Dialysis
Abstract: Purpose of review: The mortality of type 2 diabetic patients with renal disease is high during both the pre-dialysis period as well as the period under dialysis therapy. With respect to rare data in the literature it may be assumed that the mortality rate is especially high during the last year before and the first year after start of dialysis therapy. Recent findings: After reviewing the reports in the literature dealing with survival of diabetic patients with nephropathy it may be concluded that mortality is especially high during the year before and after initiating dialysis. There are exact survival data of type 2 diabetic patients under dialysis therapy but only few data concerning the survival during the last year prior to dialysis treatment. The possible reasons for this higher mortality shortly before and after start of dialysis are discussed in this article. Summary: The mortality in type 2 diabetic patients is especially high during the last year before and the first year after the start of dialysis therapy. However, only the higher mortality during the first year after initiating dialysis is well documented in the literature. Those patients who die early within 90 days of dialysis are not registered in the registries, therefore, the overall mortality during the first dialysis year is at least 5% higher than the registered. uring both periods several factors may play a causal role in the high mortality, a higher prevalence of heart failure, and a progression of macroangiopathy with higher incidence of cardiovascular events due to traditional and non-traditional risk factors, especially inflammation and oxidative stress.
Export Options
About this article
Cite this article as:
Biesenbach Georg, Highest Mortality During the Last Year Before and the First Year After Start of Dialysis Treatment in Type 2 Diabetic Patients with Nephropathy, Current Diabetes Reviews 2007; 3 (2) . https://dx.doi.org/10.2174/157339907780598234
DOI https://dx.doi.org/10.2174/157339907780598234 |
Print ISSN 1573-3998 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6417 |
Call for Papers in Thematic Issues
Advancing Diabetic Wound Healing: Mechanisms and Interventions
In recent years, diabetic wounds have become a global health concern with the increase in the incidence of diabetes. Diabetic wounds are a kind of chronic and refractory ulcer. It is generally due to the microcirculatory disturbances and the reduced levels of endogenous growth factors. Delayed cutaneous wound healing is ...read more
Oxidative and inflammatory responses in the development of secondary diabetic complications
Diabetes, along with its associated secondary complications, represents a significant global health challenge, contributing significantly to morbidity and mortality. Unhealthy lifestyle habits, reduced physical activity, environmental pollutants, and stress are pivotal factors in the onset of diabetes, particularly type-2 diabetes. Poorly managed hyperglycemia can lead to various complications, including neuropathy, ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Stroke Prevention in Patients with Non-valvular Atrial Fibrillation: New Insight in Selection of Rhythm or Rate Control Therapy and Impact of Mean Platelet Volume
Current Pharmaceutical Design Targeting Transient Receptor Potential Channels in Cardiometabolic Diseases and Myocardial Ischemia Reperfusion Injury
Current Drug Targets Epigenetic Control of MicroRNA Expression and Aging
Current Genomics Ansamycin Inhibitors of Hsp90: Natures Prototype for Anti-Chaperone Therapy
Current Topics in Medicinal Chemistry AMPK Activators as Novel Therapeutics for Type 2 Diabetes
Current Topics in Medicinal Chemistry Flavonoids Influence Epigenetic-Modifying Enzyme Activity: Structure-Function Relationships and the Therapeutic Potential for Cancer
Current Medicinal Chemistry Statins for the Prevention of First or Recurrent Stroke
Current Vascular Pharmacology Difluorinated Curcumin: A Promising Curcumin Analogue with Improved Anti-Tumor Activity and Pharmacokinetic Profile
Current Pharmaceutical Design Assessment of Cardiac Performance with Magnetic Resonance Imaging
Current Cardiology Reviews PET Imaging to Monitor Cancer Therapy
Current Pharmaceutical Biotechnology Ectodomain Shedding of ACE and ACE2 as Regulators of Their Protein Functions
Current Enzyme Inhibition Mesenchymal Stem Cell-derived Exosomes Rescue Oxygen-Glucose Deprivation-induced Injury in Endothelial Cells
Current Neurovascular Research Tumor Specific Imaging Using Tc-99m and Ga-68 Labeled Radiopharmaceuticals
Current Medical Imaging Maternal Nicotine Exposure: Long-Term Effect on Lung Integrity in the Offspring
Current Women`s Health Reviews Comparison Between 3D Echocardiography and Cardiac Magnetic Resonance Imaging (CMRI) in the Measurement of Left Ventricular Volumes and Ejection Fraction
Current Medical Imaging Pharmacological Approaches in the Treatment of Atrial Fibrillation
Current Medicinal Chemistry Safety of Systemic Biologic Agents in the Treatment of Non-malignant Skin Disorders
Current Drug Safety Peroxisome Proliferator-Activated Receptors: The Nutritionally Controlled Molecular Networks that Integrate Inflammation, Immunity and Metabolism
Current Nutrition & Food Science Inhibition of Platelet Adhesion to Collagen as a New Target for Antithrombotic Drugs
Current Drug Targets - Cardiovascular & Hematological Disorders Pharmacological Inhibition of Platelet Reactivity. Clinical and Pharmacodynamic Effects
Current Vascular Pharmacology