Current Drug Targets


Francis J. Castellino
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
Dean Emeritus, College of Science
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556


Submit Manuscript
Submit Proposal

Open Access Articles

Saccharomyces cerevisiae (Baker’s Yeast) as an Interfering RNA Expression and Delivery System open Access plus

Volume: 20   Issue: 9
Pp: 942-952
Molly Duman-Scheel*

Opportunities of Bacterial Cellulose to Treat Epithelial Tissues open Access plus

Volume: 20   Issue: 8
Pp: 808-822
Irene Anton-Sales, Uwe Beekmann, Anna Laromaine*, Anna Roig* and Dana Kralisch

Nitrite-stimulated Gastric Formation of S-nitrosothiols As An Antihypertensive Therapeutic Strategy open Access plus

Volume: 20   Issue: 4
Pp: 431-443
Gustavo H. Oliveira-Paula and Jose E. Tanus-Santos*

Blood Eosinophils as Biomarkers to Drive Treatment Choices in Asthma and COPD open Access plus

Volume: 19   Issue: 16
Pp: 1882-1896
Konstantinos Kostikas, Caterina Brindicci and Francesco Patalano*

Current Status and Perspectives on Pharmacologic Therapy for Abdominal Aortic Aneurysm open Access plus

Volume: 19   Issue: 11
Pp: 1265-1275
Koichi Yoshimura*, Noriyasu Morikage, Shizuka Nishino-Fujimoto, Akira Furutani, Bungo Shirasawa and Kimikazu Hamano

Tocotrienols Regulate Bone Loss through Suppression on Osteoclast Differentiation and Activity: A Systematic Review open Access plus

Volume: 19   Issue: 9
Pp: 1095-1107
Nur Fathiah Mohd Radzi, Noor Akmal Shareela Ismail and Ekram Alias*

TXNIP in Metabolic Regulation: Physiological Role and Therapeutic Outlook open Access plus

Volume: 18   Issue: 9
Pp: 1095-1103
Naif Mohammad Alhawiti, Saeed Al Mahri, Mohammad Azhar Aziz, Shuja Shafi Malik and Sameer Mohammad*

Aspirin Intolerance: Experimental Models for Bed-to-Bench open Access plus

Volume: 17   Issue: 16
Pp: 1963-1970
Masamichi Yamashita

Pharmacological Chaperones that Protect Tetrahydrobiopterin Dependent Aromatic Amino Acid Hydroxylases Through Different Mechanisms open Access plus

Volume: 17   Issue: 13
Pp: 1515-1526
Magnus Hole, Ana Jorge-Finnigan, Jarl Underhaug, Knut Teigen and Aurora Martinez

Structural and Functional Aspects of Class A Carbapenemases open Access plus

Volume: 17   Issue: 9
Pp: 1006-1028
Thierry Naas, Laurent Dortet and Bogdan I. Iorga

Targeted Thromboelastographic (TEG) Blood Component and Pharmacologic Hemostatic Therapy in Traumatic and Acquired Coagulopathy open Access plus

Volume: 17   Issue: 8
Pp: 954-970
Mark Walsh, Stephanie Fritz, Daniel Hake, Michael Son, Sarah Greve, Manar Jbara, Swetha Chitta, Braxton Fritz, Adam Miller, Mary K Bader, Jonathon McCollester, Sophia Binz, Alyson Liew-Spilger, Scott Thomas, Anton Crepinsek, Faisal Shariff, Victoria Ploplis and Francis J. Castellino

Insights into a Critical Role of the FOXO3a-FOXM1 Axis in DNA Damage Response and Genotoxic Drug Resistance open Access plus

Volume: 17   Issue: 2
Pp: 164-177
Gabriela Nestal de Moraes, Laura Bella, Stefania Zona, Matthew J. Burton and Eric W.-F. Lam

Biologics for Extraintestinal Manifestations of IBD open Access plus

Volume: 15   Issue: 11
Pp: 1064-1073
Stephan R. Vavricka, Michael Scharl, Martin Gubler and Gerhard Rogler

Molecular Mechanisms and Treatment of Radiation-Induced Lung Fibrosis open Access plus

Volume: 14   Issue: 11
Pp: 1347-1356
Nian-Hua Ding, Jian Jian Li and Lun-Quan Sun

Acute and Chronic Stress-Induced Disturbances of Microglial Plasticity, Phenotype and Function open Access plus

Volume: 14   Issue: 11
Pp: 1262-1276
Frederick Rohan Walker, Michael Nilsson and Kimberley Jones

Serum S100B Represents a New Biomarker for Mood Disorders open Access plus

Volume: 14   Issue: 11
Pp: 1237-1248
Matthias L. Schroeter, Julia Sacher, Johann Steiner, Peter Schoenknecht and Karsten Mueller

Perioperative Handling of Antiplatelet Drugs. A Critical Appraisal open Access plus

Volume: 14   Issue: 8
Pp: 880-888
Matteo Nicola Dario Di Minno, Marco Milone, Pasquale Mastronardi, Pasquale Ambrosino, Alessandro Di Minno, Alessandro Parolari, Elena Tremoli and Domenico Prisco

Oxidation Inhibits Iron-Induced Blood Coagulation open Access plus

Volume: 14   Issue: 1
Pp: 13-19
Etheresia Pretorius, Janette Bester, Natasha Vermeulen and Boguslaw Lipinski

Tissue-Based Approaches to Study Pharmacodynamic Endpoints in Early Phase Oncology Clinical Trials open Access plus

Volume: 13   Issue: 12
Pp: 1525-1534
Joo Ern Ang, Stan Kaye and Udai Banerji

Overcoming Drug Resistance and Treating Advanced Prostate Cancer open Access plus

Volume: 13   Issue: 10
Pp: 1308-1323
Julius Semenas, Cinzia Allegrucci, Stephen A. Boorjian, Nigel P. Mongan and Jenny Liao Persson

Molecular Pathology of Pancreatic Cancer: From Bench-to-Bedside Translation open Access plus

Volume: 13   Issue: 6
Pp: 744-752
Vincenzo Corbo, Giampaolo Tortora and Aldo Scarpa

Novel and Viable Acetylcholinesterase Target Site for Developing Effective and Environmentally Safe Insecticides open Access plus

Volume: 13   Issue: 4
Pp: 471-482
Yuan-Ping Pang, Stephen Brimijoin, David W. Ragsdale, Kun Yan Zhu and Robert Suranyi

Architecture and Conservation of the Bacterial DNA Replication Machinery, an Underexploited Drug Target open Access plus

Volume: 13   Issue: 3
Pp: 352-372
Andrew Robinson, Rebecca J. Causer and Nicholas E. Dixon

Vaccines and Other Immunological Approaches for Cancer Immunoprevention open Access plus

Volume: 12   Issue: 13
Pp: 1957-1973
Pier-Luigi Lollini, Giordano Nicoletti, Lorena Landuzzi, Federica Cavallo, Guido Forni, Carla De Giovanni and Patrizia Nanni

The Professional Phagocyte Dictyostelium discoideum as a Model Host for Bacterial Pathogens open Access plus

Volume: 12   Issue: 7
Pp: 942-954
Salvatore Bozzaro and Ludwig Eichinger

Host-Pathogen Interactions Made Transparent with the Zebrafish Model open Access plus

Volume: 12   Issue: 7
Pp: 1000-1017
Annemarie H. Meijer and Herman P. Spaink

Properties and Therapeutic Potential of Transient Receptor Potential Channels with Putative Roles in Adversity: Focus on TRPC5, TRPM2 and TRPA1 open Access plus

Volume: 12   Issue: 5
Pp: 724-736
L. H. Jiang, N. Gamper and D. J. Beech

The Molecular Mechanisms of Glucocorticoids-Mediated Neutrophil Survival open Access plus

Volume: 12   Issue: 4
Pp: 556-562
Arash S. Saffar, Heather Ashdown and Abdelilah S. Gounni

Heme Oxygenase-1 in Tumor Biology and Therapy open Access plus

Volume: 11   Issue: 12
Pp: 1551-1570
Halina Was, Jozef Dulak and Alicja Jozkowicz

Involvement of the Toxic AGEs (TAGE)-RAGE System in the Pathogenesis of Diabetic Vascular Complications: A Novel Therapeutic Strategy open Access plus

Volume: 11   Issue: 11
Pp: 1468-1482
Masayoshi Takeuchi, Jun-ichi Takino and Sho-ichi Yamagishi

The Macrophage Stimulating Protein/Ron Pathway as a Potential Therapeutic Target to Impede Multiple Mechanisms Involved in Breast Cancer Progression open Access plus

Volume: 11   Issue: 9
Pp: 1157-1168
Kelsi L. Kretschmann, Henok Eyob, Saundra S. Buys and Alana L. Welm

MicroRNA-21: From Cancer to Cardiovascular Disease open Access plus

Volume: 11   Issue: 8
Pp: 926-935
Virginija Jazbutyte and Thomas Thum

Activated Protein C and Acute Kidney Injury: Selective Targeting of PAR-1 open Access plus

Volume: 10   Issue: 12
Pp: 1212-1226
Akanksha Gupta, Mark D. Williams, William L. Macias, Bruce A. Molitoris and Brian W. Grinnell

Inflammatory Systemic Biomarkers in Setting Acute Coronary Syndromes - Effects of the Diurnal Variation open Access plus

Volume: 10   Issue: 10
Pp: 1001-1008
A. Dominguez-Rodriguez, P. Abreu-Gonzalez and J. C. Kaski

Atherosclerosis and Arterial Blood Pressure in Mice open Access plus

Volume: 8   Issue: 11
Pp: 1181-1189
Hong Lu, Lisa A. Cassis and Alan Daugherty

GSK3 at the Edge: Regulation of Developmental Specification and Cell Polarization open Access plus

Volume: 7   Issue: 11
Pp: 1411-1419
Leung Kim and Alan R. Kimmel