Current Drug Targets

Editor-in-Chief:

Francis J. Castellino
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
Dean Emeritus, College of Science
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556
USA

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Ahead of Print Article(s)

Inflammatory Cells and Proteases in Abdominal Aortic Aneurysm and its Complications

Volume:19
Jiang Haiying, Takeshi Sasaki, Enze Jin, Masafumi Kuzuya and Xianwu Cheng*

Novel Pharmacotherapeutic Approaches in Treatment of Alcohol Addiction

Volume:19
Rashidi Mohamed Pakri Mohamad, Jaya Kumar*, Shihab Udin Ahmad and Isa Naina Mohamed

Recent Updates on Novel Approaches in Insulin Drug Delivery: A Review of Challenges and Pharmaceutical Implications

Volume:19
Manisha Pandey*, Hira Choudhury, Cheah Xiao Yi, Chen Wei Mun, Goh Khang Ping, Guee Xin Rou, Bhalqish Jeet Kaur A/P Ambar Jeet Singh, Angel Ng Ann Jhee, Lee Kai Chin, Prashant Kesharwani, Bapi Gorain and Zahid Hussain

Exosomes in Therapy: Engineering, Pharmacokinetic and Future Applications

Volume:19
Claudia Arenaccio, Chiara Chiozzini, Flavia Ferrantelli, Patrizia Leone, Eleonora Olivetta and Maurizio Federico*

Nucleophagy Plays a Major Role in Human Diseases

Volume:19
Nian Fu*, XueFeng Yang and Linxi Chen

Role of the LDL Receptor-Related Protein 1 in Regulating Protease Activity and Signaling Pathways in the Vasculature

Volume:19
Dianaly T. Au, Allison L. Arai, William E. Fondrie, Selen C. Muratoglu and Dudley K. Strickland*

Non-cardiomyocytes in Heart Regeneration

Volume:19
Jie Feng, Yandong Li and Yu Nie*

Biological and Psychological Influences of Cross-sex Hormone in Transgender

Volume:19
Ling Shiao Ling, Hatta Sidi*, Raja Adam Raja Lope, Srijit Das and Azlin Baharudin

The Molecular Targets of Swertiamarin and its Derivatives Confer Anti- Diabetic and Anti-Hyperlipidemic Effects

Volume:19
Naisargee Patel*, Rajeev Kumar Tyagi, Nikunj Tandel, Neeraj Garg and Nupur Soni

Bacterial Multidrug Efflux Proteins: A Major Mechanism of Antimicrobial Resistance

Volume:19
Irshad Ahmad, Nighat Nawaz, Fatemeh Karimi Dermani, Alisa Khodadadi Kohlan, Massoud Saidijam and Simon G. Patching*

Flavonoids and its Neuroprotective Effects on Brain Ischemia and Neurodegenerative Diseases

Volume:19
Manish Putteeraj, Wei Ling Lim, Seong Lin Teoh and Mohamad Fairuz Yahaya*

ApoE4 May be a Promising Target for Treatment of Coronary Heart Disease and Alzheimer's Disease

Volume:19
Wei Chen*, Fengzhong Jin, Guihua Cao, Rong Mei, Yayun Wang, Pan Long, Xiaoming Wang and Wei Ge

New Light on An Old Friend: Targeting PUMA in Radioprotection and Therapy of Cardiovascular and Neurodegenerative Diseases

Volume:19
Ales Tichy, Jan Marek, Radim Havelek*, Jaroslav Pejchal, Martina Seifrtova, Lenka Zarybnicka, Alzbeta Filipova, Martina Rezacova and Zuzana Sinkorova

Complexation of Bioelements and Toxic Metals by Polyphenolic Compounds – Implications for Health

Volume:19
Sylwia Borowska, Malgorzata Michalina Brzoska* and Michal Tomczyk

Why Methylene Blue Have to Be Always Present in the Stocking of Emergency Antidotes

Volume:19
Caroline Floreoto Baldo, Luiza Mateus Silva, Livia Arcencio, Agnes Afrodite Sumarelli Albuquerque, Andrea Carla Celotto, Anibal Basile-Filho and Paulo Roberto B Evora*

Current Status and Perspectives on Pharmacologic Therapy for Abdominal Aortic Aneurysm

Volume:19
Koichi Yoshimura*, Noriyasu Morikage, Shizuka Nishino-Fujimoto, Akira Furutani, Bungo Shirasawa and Kimikazu Hamano

Nanoparticles in Cancer Treatment: Opportunities and Obstacles

Volume:19
Rajendra Awasthi*, Ariane Roseblade, Philip Michael Hansbro, Michael John Rathbone, Kamal Dua and Mary Bebawy

New Sides of Aldosterone Action in Cardiovascular System as Potential Targets for Therapeutic Intervention

Volume:19
Patrycjusz Kolodziejczyk, Anna Gromotowicz-Poplawska, Michal Aleksiejczuk, Ewa Chabielska, Piotr Tutka and Wojciech Miltyk*

The Use of Antidepressants for Physical and Psychological Symptoms in Cancer

Volume:19
Syahrir Zaini*, NG Chong Guan , Ahmad Hatim Sulaiman, Nor Zuraida Zainal, Hasniza Zaman Huri and Siti Hadijah Shamsudin

Potential of Liquid Biopsy in Papillary Thyroid Carcinoma in Context of miRNA, BRAF and p53 Mutation

Volume:19
Ewelina Perdas*, Robert Stawski, Dariusz Nowak and Maria Zubrzycka

A New Investigational Perspective for Purines Against Glioblastoma Invasiveness

Volume:19
Patricia Giuliani, Mariachiara Zuccarini, Marzia Carluccio, Sihana Ziberi, Patrizia Di Iorio, Francesco Caciagli and Renata Ciccarelli*

Versatility of Cancer Associated Fibroblasts: Commendable Targets for Anti-tumor Therapy

Volume:19
Ghulam Jilany Khan*, Li Sun*, Sara Khan, Shengtao Yuan and He Nongyue

Blood Eosinophils as Biomarkers to Drive Treatment Choices in Asthma and COPD

Volume:19
Konstantinos Kostikas, Caterina Brindicci and Francesco Patalano*

Enteral Administration of TKIs: Report of a Response to Ceritinib in an ALK-positive NSCLC Patient and Literature Review

Volume:19
Francesco Facchinetti, Paola Bordi*, Paola Bini, Livia Bidin, Roberta Camisa and Marcello Tiseo

Tocotrienols Regulate Bone Loss through Suppression on Osteoclast Differentiation and Activity: A Systematic Review

Volume:19
Nur Fathiah Mohd Radzi, Noor Akmal Shareela Ismail and Ekram Alias*

S-Nitrosylation in Regulation of Inflammation and Cell Damage

Volume:19
Subhajit Dasgupta*, Jenny- Jaramillo Gomez, Inderjit Singh and Mushfiquddin Khan

PPARγ-targeting Potential for Radioprotection

Volume:19
Simran Kaur, Alo Nag, Ajay Kumar Singh and Kulbhushan Sharma*

Nanocarrier Based Advances in Drug Delivery to Tumor: An Overview

Volume:19
Ankit Jain , Romi Kumari, Ankita Tiwari, Amit Verma, Amita Tripathi, Akanksha Shrivastava and Sanjay K. Jain*

Pathogenic and Therapeutic Significance of Angiotensin II Type I Receptor in Abdominal Aortic Aneurysms

Volume:19
Baohui Xu*, Haojun Xuan, Yasunori Iida, Masaaki Miyata and Ronald L Dalman

Hypoperfusion of the Aortic Wall Secondary to Degeneration of Adventitial Vasa Vasorum Causes Abdominal Aortic Aneurysms

Volume:19
Hiroki Tanaka*, Naoki Unno, Yuko Suzuki, Hideto Sano, Tatsuro Yata and Tetsumei Urano

Silk Fibroin Based Drug Delivery Applications: Promises and Challenges

Volume:19
Shahid Ud Din Wani and Gangadharappa Hosahalli Veerabhadrappa*

p53 As the Focus of Gene Therapy: Past, Present and Future

Volume:19
Joana FA Valente, Joao A Queiroz and Fani Sousa*

The Role of DNA Repair Pathways in AML Chemosensitivity

Volume:19
Elizabeth A Pearsall, Lisa F Lincz and Kathryn Anne Skelding*

Therapeutic Applications of Prostaglandins and Thromboxane A2 Inhibitors in Abdominal Aortic Aneurysms

Volume:19
Audrey Courtois*, Georgios Makrygiannis, Jean-Paul Cheramy-Bien, Audrey Purnelle, Bernard Pirotte, Jean Michel Dogné, Julien Hanson, Jean-Olivier Defraigne, Pierre Drion and Natzi Sakalihasan

Fenofibrate and Telmisartan in the Management of Abdominal Aortic Aneurysm

Volume:19
Sophie E. Rowbotham, Smriti M. Krishna, Corey S. Moran and Jonathan Golledge*

Efficacy and Safety of Serotonin Receptor Ligands in the Treatment of Irritable Bowel Syndrome: A Review

Volume:19
Agata Binienda, Martin Storr, Jakub Fichna and Maciej Salaga*

Optimal Time for Pharmacological Treatment of Abdominal Aortic Aneurysm

Volume:19
Yasunori Iida*, Shigeharu Sawa and Hideyuki Shimizu

Tocopherol and Tocotrienol: Therapeutic Potential in Animal Models of Stress

Volume:18
Mohd Fahami Nur Azlina*, Yusof Kamisah and Mohd Saad Qodriyah

Identification of Novel Ligands for Therapeutic Lipopeptides: Daptomycin, Surfactin and Polymyxin

Volume:19
Satya Eswari Jujjavarapu*, Swasti Dhagat and Vinay Kurrey

PCSK9 and Hypercholesterolemia: Therapeutic Approach

Volume:19
Milan Obradovic, Bozidarka Zaric, Emina Sudar-Milovanovic, Branislava Ilincic, Milan Perovic, Edita Stokic and Esma Isenovic*

Epigenetic Mechanisms: Role in Hematopoietic Stem Cell Lineage Commitment and Differentiation

Volume:18
Sanjeev Raghuwanshi, Swati Dahariya, Ravinder Kandi, Usha Gutti, Ram Babu Undi, Durga Shankar Sharma, Narasaiah Kovuru, Itishri Sahu, Nagendra Sastry Yarla, Raja Gopal Venakata Saladi and Ravi Kumar Gutti

Vortioxetine Treatment for Anxiety Disorder: A Meta-Analysis Study

Volume:18
Anne Yee*, Chong Guan Ng and Loh Huai Seng

Dopamine: Agonists and Neurodegenerative Disorders

Volume:18
Saba Khanam and Yasir Hasan Siddique*

Therapeutic Applications of Capsaicin in Upper Airways

Volume:18
Carlo Cavaliere*, Simonetta Masieri and Franco Cavaliere

The Effects and Action Mechanisms of Phytoestrogens on Vasomotor Symptoms During Menopausal Transition: Thermoregulatory Mechanism

Volume:18
Haryati Ahmad Hairi, Ahmad Nazrun Shuid*, Nurul Izzah Ibrahim, Jamia Azdina Jamal, Norazlina Mohamed and Isa Naina Mohamed

LncRNA HOTAIR Polymorphisms Association with Cancer Susceptibility in Different Tumor Types

Volume:18
Gerardo Botti, Francesca Collina, Giosuè Scognamiglio, Gabriella Aquino, Margherita Cerrone, Giuseppina Liguori, Vincenzo Gigantino, Maria Gabriella Malzone and Monica Cantile*

Osteoclastogenesis in Abdominal Aortic Aneurysms: A New Therapeutic Target

Volume:18
Alexander D. Leung and Dai Yamanouchi*

Schizophrenia and Nicotine Dependence: What Psychopharmacological Treatment Options are Available for the Duo Perturbationes?

Volume:18
Yoong Mei Theng, Suzaily Wahab*, Noor Alaudin Wahab, Hatta Sidi and Srijit Das

Drug Therapy for Abdominal Aortic Aneurysms Utilizing Omega-3 Unsaturated Fatty Acids and Their Derivatives

Volume:18
Daisuke Akagi, Katsuyuki Hoshina, Toshiaki Watanabe and Micheal S. Conte*

The Role of Dietary Compounds in the Therapy of Nicotine-Induced Osteoporosis

Volume:18
Norazlina Mohamed*, Norliza Muhammad, Ahmad Nazrun Shuid and Ima-Nirwana Soelaiman

Abdominal Aortic Aneurysm (AAA): Is There a Role for the Prevention and Therapy Using Antioxidants?

Volume:18
Joël Pincemail*, Jean-Olivier Defraigne, Audrey Courtois, Adelin Albert, Jean-Paul Cheramy-Bien and Natzi Sakalihasan

Kratom and Future Treatment for the Opioid Addiction and Chronic Pain: Periculo Beneficium

Volume:18
Ismaliza Ismail, Suzaily Wahab*, Hatta Sidi, Srijit Das, Loo Jiann Lin and Rosdinom Razali

Epigenetic Biomarkers for Risk Assessment of Particulate Matter Associated Lung Cancer

Volume:18
Arpit Bhargava, Neha Bunkar, Aniket Aglawe, Kailash Chand Pandey, Rajnarayan Tiwari, Koel Chaudhury, Irina Yu Goryacheva and Pradyumna Kumar Mishra*

Subduing the Green-eyed Monster: Bridging the Psychopharmacological and Psychosocial Treatment Perspective in Understanding Pathological Jealousy

Volume:18
Farah Deena Abdul Samad, Hatta Sidi*, Jaya Kumar, Srijit Das, Marhani Midin and Nurul Hazwani Hatta

Hypersexuality As a Neuropsychiatric Disorder: The Neurobiology and Treatment Options

Volume:18
Hatta Sidi*, Muna Asiff, Jaya Kumar, Srijit Das, Nurul Hazwani Hatta and Cesar Alfonso

Try to Remember: Interplay between Memory and Substance Use Disorder

Volume:18
Rashidi Mohamed Pakri Mohamed, Jaya Kumar*, Ernie Yap, Isa Naina Mohamed, Hatta Sidi, Raja Lope Adam and Srijit Das

The Bio-Psycho-Social Dimension in Women’s Sexual Desire: ‘Argumentum ad novitatem’

Volume:18
Nur Syazwani Roslan, Nik Ruzyanei Nik Jaafar, Hatta Sidi*, Najwa Baharuddin, Jaya Kumar, Srijit Das and Nik Hazlina Nik Hussein

The Novelty of Bupropion As a Dopaminergic Antidepressant for the Treatment of Adult Attention Deficit Hyperactive Disorder

Volume:18
Kanit Tha Deang, Hatta Sidi*, Hazli Zakaria, Raja Lope Adam, Srijit Das, Nurul Hazwani Hatta, Muhammad Hatta and Kok Wei Wee

The Role of Atypical Antipsychotics in Sexuality: Road to Recovery in Schizophrenia

Volume:18
Raja Lope Adam, Hatta Sidi*, Marhani Midin, Hazli Zakaria, Srijit Das and Khairi Che Mat

Co-Morbid Erectile Dysfunction (ED) and Antidepressant Treatment in a Patient – A Management Challenge?

Volume:18
Maszaidi Zainol, Hatta Sidi*, Jaya Kumar, Srijit Das, Shaiful Ismail, Muhammad Hizri Hatta, Najwa Baharudin and Arun Ravindran

The Phosphodiasterase 5-Inhibitors (PDE-5i) for Erectile Dysfunction (ED): A Therapeutic Challenge For Psychiatrists

Volume:18
Chong Siew Koon, Hatta Sidi, Jaya Kumar, Srijit Das, Ong Wan Xi, Muhammad Hizri Hatta and Cesar Alfonso

Serotonin Selective Reuptake Inhibitors (SSRIs) and Female Sexual Dysfunction (FSD): Hypothesis on Its Association and Options of Treatment

Volume:17
Nurul Azmi Mahamad Rappek, Hatta Sidi, Jaya Kumar, Sazlina Kamarazaman, Srijit Das, Ruziana Masiran, Najwa Baharudin and Muhammad Hatta

The Role of Autophagy in Rheumatic Disease

Volume:17
Yuan Feng, Bo Li, Xue Yi Li and Zhen Biao Wu