Current Drug Targets

Editor-in-Chief:

Francis J. Castellino
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
Dean Emeritus, College of Science
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556
USA

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Ahead of Print Article(s)

PPARγ-targeting Potential for Radioprotection

Volume:19
Simran Kaur, Alo Nag, Ajay Kumar Singh and Kulbhushan Sharma*

Nanocarrier Based Advances in Drug Delivery to Tumor: An Overview

Volume:19
Ankit Jain , Romi Kumari, Ankita Tiwari, Amit Verma, Amita Tripathi, Akanksha Shrivastava and Sanjay K. Jain*

New Advances in Atrial Fibrillation Management: The Role of Apixaban

Volume:18
Giuseppe MC Rosano, Ilaria Spoletini*, Walter Gianni and Cristiana Vitale

Pathogenic and Therapeutic Significance of Angiotensin II Type I Receptor in Abdominal Aortic Aneurysms

Volume:19
Baohui Xu*, Haojun Xuan, Yasunori Iida, Masaaki Miyata and Ronald L Dalman

Hypoperfusion of the Aortic Wall Secondary to Degeneration of Adventitial Vasa Vasorum Causes Abdominal Aortic Aneurysms

Volume:19
Hiroki Tanaka*, Naoki Unno, Yuko Suzuki, Hideto Sano, Tatsuro Yata and Tetsumei Urano

Silk Fibroin Based Drug Delivery Applications: Promises and Challenges

Volume:19
Shahid Ud Din Wani and Gangadharappa Hosahalli Veerabhadrappa*

p53 As the Focus of Gene Therapy: Past, Present and Future

Volume:19
Joana FA Valente, Joao A Queiroz and Fani Sousa*

The Role of DNA Repair Pathways in AML Chemosensitivity

Volume:19
Elizabeth A Pearsall, Lisa F Lincz and Kathryn Anne Skelding*

Current Status and Perspectives on Pharmacologic Therapy for Abdominal Aortic Aneurysm

Volume:19
Koichi Yoshimura*, Noriyasu Morikage, Shizuka Nishino-Fujimoto, Akira Furutani, Bungo Shirasawa and Kimikazu Hamano

Therapeutic Applications of Prostaglandins and Thromboxane A2 Inhibitors in Abdominal Aortic Aneurysms

Volume:19
Audrey Courtois*, Georgios Makrygiannis, Jean-Paul Cheramy-Bien, Audrey Purnelle, Bernard Pirotte, Jean Michel Dogné, Julien Hanson, Jean-Olivier Defraigne, Pierre Drion and Natzi Sakalihasan

Fenofibrate and Telmisartan in the Management of Abdominal Aortic Aneurysm

Volume:19
Sophie E. Rowbotham, Smriti M. Krishna, Corey S. Moran and Jonathan Golledge*

Efficacy and Safety of Serotonin Receptor Ligands in the Treatment of Irritable Bowel Syndrome: A Review

Volume:19
Agata Binienda, Martin Storr, Jakub Fichna and Maciej Salaga*

Optimal Time for Pharmacological Treatment of Abdominal Aortic Aneurysm

Volume:19
Yasunori Iida*, Shigeharu Sawa and Hideyuki Shimizu

Tocopherol and Tocotrienol: Therapeutic Potential in Animal Models of Stress

Volume:18
Mohd Fahami Nur Azlina*, Yusof Kamisah and Mohd Saad Qodriyah

Identification of Novel Ligands for Therapeutic Lipopeptides: Daptomycin, Surfactin and Polymyxin

Volume:19
Satya Eswari Jujjavarapu*, Swasti Dhagat and Vinay Kurrey

PCSK9 and Hypercholesterolemia: Therapeutic Approach

Volume:19
Milan Obradovic, Bozidarka Zaric, Emina Sudar-Milovanovic, Branislava Ilincic, Milan Perovic, Edita Stokic and Esma Isenovic*

Epigenetic Mechanisms: Role in Hematopoietic Stem Cell Lineage Commitment and Differentiation

Volume:18
Sanjeev Raghuwanshi, Swati Dahariya, Ravinder Kandi, Usha Gutti, Ram Babu Undi, Durga Shankar Sharma, Narasaiah Kovuru, Itishri Sahu, Nagendra Sastry Yarla, Raja Gopal Venakata Saladi and Ravi Kumar Gutti

Natural Polyphenols in the Treatment of Alzheimer’s Disease

Volume:18
Syed-Badrul Syarifah-Noratiqah, Isa Naina-Mohamed*, Mohamed S Zulfarina and H M S Qodriyah

Vortioxetine Treatment for Anxiety Disorder: A Meta-Analysis Study

Volume:18
Anne Yee*, Chong Guan Ng and Loh Huai Seng

Dopamine: Agonists and Neurodegenerative Disorders

Volume:18
Saba Khanam and Yasir Hasan Siddique*

Therapeutic Applications of Capsaicin in Upper Airways

Volume:18
Carlo Cavaliere*, Simonetta Masieri and Franco Cavaliere

Main Isoflavones Found in Dietary Sources as Natural Anti-inflammatory Agents

Volume:18
Corina Danciu*, Stefana Avram, Ioana Pavel, Roxana Ghiulai, Cristina Dehelean, Alexa Ersilia, Daliana Minda, Cristina Petrescu, Elena Moaca and Codruta Soica

The Effects and Action Mechanisms of Phytoestrogens on Vasomotor Symptoms During Menopausal Transition: Thermoregulatory Mechanism

Volume:18
Haryati Ahmad Hairi, Ahmad Nazrun Shuid*, Nurul Izzah Ibrahim, Jamia Azdina Jamal, Norazlina Mohamed and Isa Naina Mohamed

LncRNA HOTAIR Polymorphisms Association with Cancer Susceptibility in Different Tumor Types

Volume:18
Gerardo Botti, Francesca Collina, Giosuè Scognamiglio, Gabriella Aquino, Margherita Cerrone, Giuseppina Liguori, Vincenzo Gigantino, Maria Gabriella Malzone and Monica Cantile*

Osteoclastogenesis in Abdominal Aortic Aneurysms: A New Therapeutic Target

Volume:18
Alexander D. Leung and Dai Yamanouchi*

A Review on the Effects of Testosterone Supplementation in Hypogonadal Men with Cognitive Impairment

Volume:18
Nur Vaizura Mohamad , Soelaiman Ima-Nirwana and Kok-Yong Chin*

Schizophrenia and Nicotine Dependence: What Psychopharmacological Treatment Options are Available for the Duo Perturbationes?

Volume:18
Yoong Mei Theng, Suzaily Wahab*, Noor Alaudin Wahab, Hatta Sidi and Srijit Das

Drug Therapy for Abdominal Aortic Aneurysms Utilizing Omega-3 Unsaturated Fatty Acids and Their Derivatives

Volume:18
Daisuke Akagi, Katsuyuki Hoshina, Toshiaki Watanabe and Micheal S. Conte*

The Role of Dietary Compounds in the Therapy of Nicotine-Induced Osteoporosis

Volume:18
Norazlina Mohamed*, Norliza Muhammad, Ahmad Nazrun Shuid and Ima-Nirwana Soelaiman

Abdominal Aortic Aneurysm (AAA): Is There a Role for the Prevention and Therapy Using Antioxidants?

Volume:18
Joël Pincemail*, Jean-Olivier Defraigne, Audrey Courtois, Adelin Albert, Jean-Paul Cheramy-Bien and Natzi Sakalihasan

Vitamin D and Depression: The Evidence from an Indirect Clue to Treatment Strategy

Volume:18
Sok Kuan Wong, Kok Yong Chin and Soelaiman Ima-Nirwana*

Kratom and Future Treatment for the Opioid Addiction and Chronic Pain: Periculo Beneficium

Volume:18
Ismaliza Ismail, Suzaily Wahab*, Hatta Sidi, Srijit Das, Loo Jiann Lin and Rosdinom Razali

Epigenetic Biomarkers for Risk Assessment of Particulate Matter Associated Lung Cancer

Volume:18
Arpit Bhargava, Neha Bunkar, Aniket Aglawe, Kailash Chand Pandey, Rajnarayan Tiwari, Koel Chaudhury, Irina Yu Goryacheva and Pradyumna Kumar Mishra*

Subduing the Green-eyed Monster: Bridging the Psychopharmacological and Psychosocial Treatment Perspective in Understanding Pathological Jealousy

Volume:18
Farah Deena Abdul Samad, Hatta Sidi*, Jaya Kumar, Srijit Das, Marhani Midin and Nurul Hazwani Hatta

Metformin, A New Era for an Old Drug in the Treatment of Immune Mediated Disease?

Volume:18
Mark Schuiveling, Nadia Vazirpanah, Timothy R.D.J. Radstake, Maili Zimmermann and Jasper C.A. Broen*

Prevalence and Clinical Significance of Visible Oral Lesions in Patients with Fanconi Anemia at Risk for Head and Neck Cancer

Volume:18
Eunike Velleuer*, Ralf Dietrich, Amy Frohnmayer, Natalia Pomjanski, Laura E. Hays and Stefan Biesterfeld

Monoterpenes as Perspective to Chronic Pain Management: A Systematic Review

Volume:18
Daniele Nascimento Gouveia, Lícia Tairiny Santos Pina, Thallita Kelly Rabelo, Wagner Barbosa da Rocha Santos, Jullyana S. S. Quintans and Adriana Gibara Guimarães*

Urinary Bone Turnover Markers as Target Indicators for Monitoring Bisphosphonate Drug Treatment in the Management of Osteoporosis

Volume:18
Sohyea Kwon, Anne Wang, Cheryl Sadowski, Nese Yuksel and Michael Roman Doschak*

Recent Advances in Polymer-based Wound Dressings for the Treatment of Diabetic Foot Ulcer: An Overview of State-of-the-art

Volume:18
Zahid Hussain*, Hnin Ei Thu, Ahmad Nazrun Shuid, Haliza Katas and Fahad Hussain

Targeting Cholinergic System to Modulate Liver Injury

Volume:18
Ravirajsinh N Jadeja, Vikrant P. Rachakonda and Sandeep Khurana*

Hypersexuality As a Neuropsychiatric Disorder: The Neurobiology and Treatment Options

Volume:18
Hatta Sidi*, Muna Asiff, Jaya Kumar, Srijit Das, Nurul Hazwani Hatta and Cesar Alfonso

GRP78 Influences Chemoresistance and Prognosis in Cancer

Volume:18
Jenifer B. Gifford and Reginald Hill*

Try to Remember: Interplay between Memory and Substance Use Disorder

Volume:18
Rashidi Mohamed Pakri Mohamed, Jaya Kumar*, Ernie Yap, Isa Naina Mohamed, Hatta Sidi, Raja Lope Adam and Srijit Das

The Bio-Psycho-Social Dimension in Women’s Sexual Desire: ‘Argumentum ad novitatem’

Volume:18
Nur Syazwani Roslan, Nik Ruzyanei Nik Jaafar, Hatta Sidi*, Najwa Baharuddin, Jaya Kumar, Srijit Das and Nik Hazlina Nik Hussein

Potential Use of Modulators of Oxidative Stress as Add-on Therapy in Patients with Anxiety Disorders

Volume:18
Paolo Boldrini*, Antonella Fusco, Ferdinando Nicoletti, Aldo Badiani and Luciano Saso

The Novelty of Bupropion As a Dopaminergic Antidepressant for the Treatment of Adult Attention Deficit Hyperactive Disorder

Volume:18
Kanit Tha Deang, Hatta Sidi*, Hazli Zakaria, Raja Lope Adam, Srijit Das, Nurul Hazwani Hatta, Muhammad Hatta and Kok Wei Wee

AMP-activated Protein Kinase as a Drug Target in Chronic Kidney Disease

Volume:18
Soumaya Allouch and Shankar Munusamy*

Personalizing Psychological Treatment Along the IBD Journey: From Diagnosis to Surgery

Volume:18
Julia Menichetti*, Gionata Fiorino and Elena Vegni

Alcohol Addiction- Metabotropic Glutamate Receptor Subtype 5 and its Ligands: How They All Come Together

Volume:18
Jaya Kumar*, Zalina Ismail, Nurul Hazwani Hatta, Najwa Baharuddin, Hermizi Hapidin, Yvonne-Tee Get Bee, Ernie Yap and Rashidi Mohamed Pakri Mohamed

The Role of Atypical Antipsychotics in Sexuality: Road to Recovery in Schizophrenia

Volume:18
Raja Lope Adam, Hatta Sidi*, Marhani Midin, Hazli Zakaria, Srijit Das and Khairi Che Mat

Drug Resistance of Enzalutamide in CRPC

Volume:18
Xuedong Chen, Jieyang Lu, Liqun Xia and Gonghui Li *

Current Drug Target on Personalized medicine in IBD Can we predict disease course with clinical factors?

Volume:18
Zsuzsanna Vegh, Zsuzsanna Kurti, Petra Anna Golovics and Peter Laszlo Lakatos*

The Use of Methylphenidate for Physical and Psychological Symptoms in Cancer Patients: A Review

Volume:18
Beatrice Andrew, Ng Chong Guan* and Nik Ruzyanei Nik Jaafar

Co-Morbid Erectile Dysfunction (ED) and Antidepressant Treatment in a Patient – A Management Challenge?

Volume:18
Maszaidi Zainol, Hatta Sidi*, Jaya Kumar, Srijit Das, Shaiful Ismail, Muhammad Hizri Hatta, Najwa Baharudin and Arun Ravindran

The Neurobiology and Psychiatric Perspective of Vaginismus: Linking the Pharmacological and Psycho-Social Interventions

Volume:18
Zuri Shahidii Kadir, Hatta Sidi, Jaya Kumar, Srijit Das, Marhani Midin and Najwa Baharuddin

Recent Advances in Protein Tyrosine Phosphatase 1B Targeted Drug Discovery for Type II Diabetes and Obesity

Volume:18
Neelesh Maheswari, Chandrabose Karthikeyan, Piyush Trivedi and N.S. Hari Narayana Moorthy

The Phosphodiasterase 5-Inhibitors (PDE-5i) for Erectile Dysfunction (ED): A Therapeutic Challenge For Psychiatrists

Volume:18
Chong Siew Koon, Hatta Sidi, Jaya Kumar, Srijit Das, Ong Wan Xi, Muhammad Hizri Hatta and Cesar Alfonso

Serotonin Selective Reuptake Inhibitors (SSRIs) and Female Sexual Dysfunction (FSD): Hypothesis on Its Association and Options of Treatment

Volume:17
Nurul Azmi Mahamad Rappek, Hatta Sidi, Jaya Kumar, Sazlina Kamarazaman, Srijit Das, Ruziana Masiran, Najwa Baharudin and Muhammad Hatta

β3-Adrenoceptor Control of Lower Genitourinary Tract Organs and Function in Male: An Overview

Volume:18
Ecem Kaya, Suresh C Sikka, Didem Yilmaz Oral, Isil Ozakca and Serap Gur

Understanding the Pathophysiology of Premature Ejaculation: Bridging the Link between Pharmacological and Psychological Interventions

Volume:17
Hatta Sidi, Farid Yusof, Srijit Das, Marhani Midin, Jaya Kumar and Muhammd Hizri Hatta

Can Surgery for Inflammatory Bowel Disease be Personalized?

Volume:18
Antonino Spinelli, Alessandra Marano, Claudio Bacchelli, Nicolò Maria Mariani, Marco Montorsi and Paulo Gustavo Kotze

JAK/STAT Signal Transduction: Promising Attractive Targets for Immune, Inflammatory and Hematopoietic Diseases

Volume:17
Qianwen Gao, Xuewu Liang, Abdul Sami Shaikh, Jie Zang, Wenfang Xu and Yingjie Zhang

The Role of Autophagy in Rheumatic Disease

Volume:17
Yuan Feng, Bo Li, Xue Yi Li and Zhen Biao Wu

Current Approach for the Diagnosis of Aplastic Anemia

Volume:17
Alicia Rovo and Andre Tichelli

Pancreatic Neoplasms and Autophagy

Volume:17
Linzi A. Barton and Jun Ren