Current Drug Targets


Francis J. Castellino
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
Dean Emeritus, College of Science
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556


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Editorial [Hot Topic: Mitochondria as a Drug Target in Health and Disease (Guest Editor: Paulo J. Oliveira)] promotion: free to download

Volume:12   Issue: 6
Pp: 761-761
Paulo J. Oliveira
DOI: 10.2174/138945011795528912

Mild Mitochondrial Uncoupling as a Therapeutic Strategy

Volume:12   Issue: 6
Pp: 783-789
Fernanda M. Cunha, Camille C. Caldeira da Silva, Fernanda M. Cerqueira and Alicia J. Kowaltowski
DOI: 10.2174/138945011795528778

Mitophagy in Neurodegeneration: An Opportunity for Therapy?

Volume:12   Issue: 6
Pp: 790-799
R. X. Santos, S. C. Correia, C. Carvalho, S. Cardoso, M. S. Santos and P. I. Moreira
DOI: 10.2174/138945011795528813

Mitochondrial-Targeted Plastoquinone Derivatives. Effect on Senescence and Acute Age-Related Pathologies

Volume:12   Issue: 6
Pp: 800-826
M. V. Skulachev, Y. N. Antonenko, V. N. Anisimov, B. V. Chernyak, D. A. Cherepanov, V. A. Chistyakov, M. V. Egorov, N. G. Kolosova, G. A. Korshunova, K. G. Lyamzaev, E. Y. Plotnikov, V. A. Roginsky, A. Y. Savchenko, I. I. Severina, F. F. Severin, T. P. Shkurat, V. N. Tashlitsky, K. M. Shidlovsky, M. Y. Vyssokikh, A. A. Zamyatnin, D. B. Zorov and V. P. Skulachev
DOI: 10.2174/138945011795528859

Mitochondrial Tolerance to Drugs and Toxic Agents in Ageing and Disease

Volume:12   Issue: 6
Pp: 827-849
Jan Suski, Magdalena Lebiedzinska, Nuno G. Machado, Paulo J. Oliveira, Paolo Pinton, Jerzy Duszynski and Mariusz R. Wieckowski
DOI: 10.2174/138945011795529029

Berberine as a Promising Safe Anti-Cancer Agent- Is there a Role for Mitochondria?

Volume:12   Issue: 6
Pp: 850-859
Catia V. Diogo, Nuno G. Machado, Ines A. Barbosa, Teresa L. Serafim, Ana Burgeiro and Paulo J. Oliveira
DOI: 10.2174/138945011795528930

Mitochondria as a Target for Exercise-Induced Cardioprotection

Volume:12   Issue: 6
Pp: 860-871
Antonio Ascensao, Jose Lumini-Oliveira, Paulo J. Oliveira and Jose Magalhaes
DOI: 10.2174/138945011795529001

Regulation of Mitochondrial Biogenesis in Metabolic Syndrome

Volume:12   Issue: 6
Pp: 872-878
Anabela P. Rolo, Ana P. Gomes and Carlos M. Palmeira
DOI: 10.2174/138945011795529056

Mitochondria in Chronic Liver Disease

Volume:12   Issue: 6
Pp: 879-893
Ignazio Grattagliano, Stefan Russmann, Catia Diogo, Leonilde Bonfrate, Paulo J. Oliveira, David Q.-H. Wang and Piero Portincasa
DOI: 10.2174/138945011795528877

The Adenine Nucleotide Translocase 2, a Mitochondrial Target for Anticancer Biotherapy

Volume:12   Issue: 6
Pp: 894-901
Ossama Sharaf el dein, Eleonore Mayola, Joel Chopineau and Catherine Brenner
DOI: 10.2174/138945011795529047

The NK-1 Receptor: A New Target in Cancer Therapy

Volume:12   Issue: 6
Pp: 909-921
Miguel Munoz, Marisa Rosso and Rafael Covenas
DOI: 10.2174/138945011795528796