Current Drug Targets

Editor-in-Chief:

Francis J. Castellino
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
Dean Emeritus, College of Science
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556
USA

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Editor's Choice

The Role of Dietary Compounds in the Therapy of Nicotine-Induced Osteoporosis

Volume: 19   Issue: 12
Pp: 1424-1430
Norazlina Mohamed*, Norliza Muhammad, Ahmad Nazrun Shuid and Ima-Nirwana Soelaiman
DOI: 10.2174/1389450118666170925154428

Role of the LDL Receptor-Related Protein 1 in Regulating Protease Activity and Signaling Pathways in the Vasculature

Volume: 19   Issue: 11
Pp: 1276-1288
Dianaly T. Au, Allison L. Arai, William E. Fondrie, Selen C. Muratoglu* and Dudley K. Strickland*
DOI: 10.2174/1389450119666180511162048

The Role of DNA Repair Pathways in AML Chemosensitivity

Volume: 19   Issue: 10
Pp: 1205-1219
Elizabeth A. Pearsall, Lisa F. Lincz and Kathryn A. Skelding*
DOI: 10.2174/1389450119666180110093713

Ubiquitin and ubiquitin-like proteins in cardiac disease and protection

Volume: 19   Issue: 9
Pp: 989-1002
Jie Li, John A. Johnson and Huabo Su*
DOI: 10.2174/1389450117666151209114608

Macrophage Polarization as a Therapeutic Target in Myocardial Infarction

Volume: 19   Issue: 6
Pp: 651-662
Yuanyuan Cheng and Jianhui Rong*
DOI: 10.2174/1389450118666171031115025

Zoledronic Acid: Pleiotropic Anti-Tumor Mechanism and Therapeutic Outlook for Osteosarcoma

Volume: 19   Issue: 5
Pp: 409-421
Zhengxiao Ouyang, Haowei Li, Zanjing Zhai, Jiake Xu, Crispin R. Dass, An Qin* and Kerong Dai*
DOI: 10.2174/1573399811666150615145409

Smart Triggered Release in Controlled Drug Delivery

Volume: 19   Issue: 4
Pp: 318-327
Paul Catalin Balaure, Dragos Gudovan* and Iulia Alexandra Gudovan
DOI: 10.2174/1389450117666160401125034

Virulence Factor Targeting of the Bacterial Pathogen Staphylococcus aureus for Vaccine and Therapeutics

Volume: 19   Issue: 2
Pp: 111-127
Trevor L. Kane, Katelyn E. Carothers and Shaun W. Lee*
DOI: 10.2174/1389450117666161128123536

Cytochrome P450 Structure, Function and Clinical Significance: A Review promotion: free to download

Volume: 19   Issue: 1
Pp: 38-54
Palrasu Manikandan and Siddavaram Nagini*
DOI: 10.2174/1389450118666170125144557

Targeting Transient Receptor Potential Channels in Cardiometabolic Diseases and Myocardial Ischemia Reperfusion Injury

Volume: 18   Issue: 15
Pp: 1733-1745
Jipeng Ma, Lifang Yang, Yanyan Ma, Xiaowu Wang, Jun Ren* and Jian Yang*
DOI: 10.2174/1389450116666151019102052

The Smart Programmable CRISPR Technology: A Next Generation Genome Editing Tool for Investigators

Volume: 18   Issue: 14
Pp: 1653-1663
Chiranjib Chakraborty, Seong Lin Teoh and Srijit Das*
DOI: 10.2174/1389450117666160527142321

The Molecular Concept of Atheromatous Plaques

Volume: 18   Issue: 11
Pp: 1250-1258
Zar Chi Thent, Chiranjib Chakraborty, Pasuk Mahakkanukrauh, Nik Nik Ritza Kosai Nik Mahmood, Reynu Rajan and Srijit Das*
DOI: 10.2174/1389450117666160502151600

Epigenetic Effects of Environmental Chemicals on Reproductive Biology

Volume: 18   Issue: 10
Pp: 1116-1124
Maria Strazzullo* and Maria Rosaria Matarazzo
DOI: 10.2174/1389450117666161025100125

Inflammasome in Dendritic Cells Immunobiology: Implications to Diseases and Therapeutic Strategies

Volume: 18   Issue: 9
Pp: 1003-1018
Isabel Ferreira, Joana Liberal, Joao D Martins, Ana Silva, Bruno Miguel Neves* and Maria Teresa Cruz*
DOI: 10.2174/1389450117666160921144830

Rationale and Prospects of Targeting Bacterial Two-component Systems for Antibacterial Treatment of Cystic Fibrosis Patients open access plus

Volume: 18   Issue: 6
Pp: 687-695
Nadya Velikova* and Jerry M. Wells
DOI: 10.2174/1389450117666160208145934

Docking Studies for Multi-Target Drugs open access plus

Volume: 18   Issue: 5
Pp: 592-604
Luciana Scotti, Francisco J.B. Mendonca Junior, Hamilton M. Ishiki, Frederico F. Ribeiro, Rajeev K. Singla, Jose M. Barbosa Filho, Marcelo S. Da Silva and Marcus T. Scotti
DOI: 10.2174/1389450116666150825111818

Plant-derived Compounds as Potential Source of Novel Anti-Biofilm Agents Against Pseudomonas aeruginosa open access plus

Volume: 18   Issue: 4
Pp: 414-420
Pooi Yin Chung
DOI: 10.2174/1389450117666161019102025

Do We Need Full Donor Chimerism? How Alloreactive Cell Therapies without Substantial Engraftment Might Treat Hematologic Cancers

Volume: 18   Issue: 3
Pp: 281-295
Elizabeth F. Krakow, Hui-Sheng Ai, Brian Shaffer, Jean-Sebastien Delisle, Kai-Xun Hu and Anthony D. Sung
DOI: 10.2174/1389450116666150304103849

New Pharmacological Approaches Using Polyphenols on the Physiopathology of Neuropathic Pain

Volume: 18   Issue: 2
Pp: 160-173
Pere Boadas-Vaello, Jose Miguel Vela and Enrique Verdu
DOI: 10.2174/1389450117666160527142423

Non Coding RNAs: A New Avenue for the Self-Tailoring of Blood Cancer Treatment

Volume: 18   Issue: 1
Pp: 35-55
Gabriella Misso, Mayra Rachele Zarone, Anna Grimaldi, Maria Teresa Di Martino, Angela Lombardi, Hiromichi Kawasaki, Paola Stiuso, Pierfrancesco Tassone, Pierosandro Tagliaferri and Michele Caraglia
DOI: 10.2174/1389450117666160606104208

Astrocytes: Adhesion Molecules and Immunomodulation

Volume: 17   Issue: 16
Pp: 1871-1881
Shane Liddelow and Daniel Hoyer
DOI: 10.2174/1389450117666160101120703

The Challenges of Modeling Drug Resistance to Antiangiogenic Therapy

Volume: 17   Issue: 15
Pp: 1747-1754
Michalis Mastri, Spencer Rosario, Amanda Tracz, Robin E. Frink, Rolf A. Brekken and John M. L. Ebos
DOI: 10.2174/1389450117666151209123544

Pharmacological Chaperones that Protect Tetrahydrobiopterin Dependent Aromatic Amino Acid Hydroxylases Through Different Mechanisms open access plus

Volume: 17   Issue: 13
Pp: 1515-1526
Magnus Hole, Ana Jorge-Finnigan, Jarl Underhaug, Knut Teigen and Aurora Martinez
DOI: 10.2174/1389450117666160307143512

Tapping into Mitochondria to Find Novel Targets for Diabetes Complications

Volume: 17   Issue: 12
Pp: 1341-1349
Nicole B. Flemming, Linda A. Gallo, Micheal S. Ward and Josephine M. Forbes
DOI: 10.2174/1389450116666150727114410

Resolving Inflammation in Heart Failure: Novel Protective Lipid Mediators

Volume: 17   Issue: 10
Pp: 1206-1223
Marta Reina-Couto, Luís Vale, Jorge Carvalho, Paulo Bettencourt, António Albino-Teixeira and Teresa Sousa
DOI: 10.2174/1389450117666160101121135

Emerging Immunotargets in Metastatic Renal Cell Carcinoma

Volume: 17   Issue: 7
Pp: 771-776
John Kucharczyk, Marc R. Matrana, Matteo Santoni, Francesco Massari, Marina Scarpelli, Liang Cheng, Antonio Lopez-Beltran, Stefano Cascinu, Rodolfo Montironi and Moch Holger
DOI: 10.2174/1389450117666151209115753

Tuning T Cell Activation: The Function of CD6 At the Immunological Synapse and in T Cell Responses open access plus

Volume: 17   Issue: 6
Pp: 630-639
Rita F. Santos, Liliana Oliveira and Alexandre M. Carmo
DOI: 10.2174/1389450116666150531152439

Metabotropic Glutamate Receptors in Central Nervous System Diseases open access plus

Volume: 17   Issue: 5
Pp: 538-616

DOI: 10.2174/1389450116666150316224011

Roles of Apoptosis and Cellular Senescence in Cancer and Aging

Volume: 17   Issue: 4
Pp: 405-415
Claudia Cerella, Cindy Grandjenette, Mario Dicato and Marc Diederich
DOI: 10.2174/1389450116666150202155915

Targeting the Bone Microenvironment in Metastatic Castration-Resistant Prostate Cancer

Volume: 17   Issue: 3
Pp: 276-289
Pavlos Msaouel, Jose Nahun Galeas, Alejandro Recio Boiles, Ramiro Rancier Ruiz and Michael Koutsilieris
DOI: 10.2174/1389450116666150420143932

Release of Soluble Ligands for the Activating NKG2D Receptor: One More Immune Evasion Strategy Evolved by HIV-1 ? promotion: free to download

Volume: 17   Issue: 1
Pp: 54-64
Erica Giuliani, Lia Vassena, Cristina Cerboni and Margherita Doria
DOI: 10.2174/1389450116666150630110329

Phosphonate Emerging Zinc Binding Group in Matrix Metalloproteinase Inhibitors

Volume: 16   Issue: 14
Pp: 1634-1644
Cristina Campestre, Mariangela Agamennone, Marilena Tauro and Paolo Tortorella
DOI: 10.2174/1389450116666150113121733

Impairment of Liver Glycogen Storage in the db/db Animal Model of Type 2 Diabetes: A Potential Target for Future Therapeutics?

Volume: 16   Issue: 10
Pp: 1088-1093
Mitchell A. Sullivan, Brooke E. Harcourt, Ping Xu, Josephine M. Forbes and Robert G. Gilbert
DOI: 10.2174/1389450116666150727123115

Opportunities for Photoacoustic-Guided Drug Delivery

Volume: 16   Issue: 6
Pp: 571-581
Jun Xia, Chulhong Kim and Jonathan F. Lovell
DOI: 10.2174/1389450116666150707100328

Molecular Pathophysiology of Priapism: Emerging Targets

Volume: 16   Issue: 5
Pp: 474-483
Uzoma A. Anele, Belinda F. Morrison and Arthur L. Burnett
DOI: 10.2174/1389450115666141111111842

Cardiovascular Complications in Inflammatory Bowel Disease

Volume: 16   Issue: 3
Pp: 181-188
Rudolf Schicho, Gunther Marsche and Martin Storr
DOI: 10.2174/1389450116666150202161500

Molecular Foundations for Personalized Therapy in Prostate Cancer

Volume: 16   Issue: 2
Pp: 103-114
Kurt W. Fisher, Rodolfo Montironi, Antonio Lopez Beltran, Holger Moch, Lisha Wang, Marina Scarpelli, Sean R. Williamson, Michael O. Koch and Liang Cheng
DOI: 10.2174/1389450115666141229154500

Affinity-Based Methods in Drug-Target Discovery promotion: free to download

Volume: 16   Issue: 1
Pp: 60-76
Gabriela Rylova, Tomas Ozdian, Lakshman Varanasi, Miroslav Soural, Jan Hlavac, Dusan Holub, Petr Dzubak and Marian Hajduch
DOI: 10.2174/1389450115666141120110323

Synergistic Activity of the c-Met and Tubulin Inhibitor Tivantinib (ARQ197) with Pemetrexed in Mesothelioma Cells

Volume: 15   Issue: 14
Pp: 1331-1340
Leticia G. Leon, Maria Gemelli, Rocco Sciarrillo, Amir Avan, Niccola Funel and Elisa Giovannetti
DOI: 10.2174/1389450116666141205160924

Targeting SUMOylation Cascade for Diabetes Management

Volume: 15   Issue: 12
Pp: 1094-1106
Dornadula Sireesh, Elango Bhakkiyalakshmi, Kunka Mohanrama Ramkumar, Shanmugakani Rathinakumar, Panneer Selvam Anto Jennifer, Palanisamy Rajaguru and Ramasamy Paulmurugan
DOI: 10.2174/1389450115666140915124747