Current Drug Targets

Francis J. Castellino
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
Dean Emeritus, College of Science
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556
USA

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The Molecular Concept of Atheromatous Plaques

Volume: 18   Issue: 11
Pp: 1250-1258
Zar Chi Thent, Chiranjib Chakraborty, Pasuk Mahakkanukrauh, Nik Nik Ritza Kosai Nik Mahmood, Reynu Rajan and Srijit Das*
DOI: 10.2174/1389450117666160502151600

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Epigenetic Effects of Environmental Chemicals on Reproductive Biology

Volume: 18   Issue: 10
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Maria Strazzullo* and Maria Rosaria Matarazzo
DOI: 10.2174/1389450117666161025100125

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Inflammasome in Dendritic Cells Immunobiology: Implications to Diseases and Therapeutic Strategies

Volume: 18   Issue: 9
Pp: 1003-1018
Isabel Ferreira, Joana Liberal, Joao D Martins, Ana Silva, Bruno Miguel Neves* and Maria Teresa Cruz*
DOI: 10.2174/1389450117666160921144830

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Docking Studies for Multi-Target Drugs

Volume: 18   Issue: 5
Pp: 592-604
Luciana Scotti, Francisco J.B. Mendonca Junior, Hamilton M. Ishiki, Frederico F. Ribeiro, Rajeev K. Singla, Jose M. Barbosa Filho, Marcelo S. Da Silva and Marcus T. Scotti
DOI: 10.2174/1389450116666150825111818

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Do We Need Full Donor Chimerism? How Alloreactive Cell Therapies without Substantial Engraftment Might Treat Hematologic Cancers

Volume: 18   Issue: 3
Pp: 281-295
Elizabeth F. Krakow, Hui-Sheng Ai, Brian Shaffer, Jean-Sebastien Delisle, Kai-Xun Hu and Anthony D. Sung
DOI: 10.2174/1389450116666150304103849

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Non Coding RNAs: A New Avenue for the Self-Tailoring of Blood Cancer Treatment

Volume: 18   Issue: 1
Pp: 35-55
Gabriella Misso, Mayra Rachele Zarone, Anna Grimaldi, Maria Teresa Di Martino, Angela Lombardi, Hiromichi Kawasaki, Paola Stiuso, Pierfrancesco Tassone, Pierosandro Tagliaferri and Michele Caraglia
DOI: 10.2174/1389450117666160606104208

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Astrocytes: Adhesion Molecules and Immunomodulation

Volume: 17   Issue: 16
Pp: 1871-1881
Shane Liddelow and Daniel Hoyer
DOI: 10.2174/1389450117666160101120703

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The Challenges of Modeling Drug Resistance to Antiangiogenic Therapy

Volume: 17   Issue: 15
Pp: 1747-1754
Michalis Mastri, Spencer Rosario, Amanda Tracz, Robin E. Frink, Rolf A. Brekken and John M. L. Ebos
DOI: 10.2174/1389450117666151209123544

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Pharmacological Chaperones that Protect Tetrahydrobiopterin Dependent Aromatic Amino Acid Hydroxylases Through Different Mechanisms open access plus

Volume: 17   Issue: 13
Pp: 1515-1526
Magnus Hole, Ana Jorge-Finnigan, Jarl Underhaug, Knut Teigen and Aurora Martinez
DOI: 10.2174/1389450117666160307143512

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Tapping into Mitochondria to Find Novel Targets for Diabetes Complications

Volume: 17   Issue: 12
Pp: 1341-1349
Nicole B. Flemming, Linda A. Gallo, Micheal S. Ward and Josephine M. Forbes
DOI: 10.2174/1389450116666150727114410

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Resolving Inflammation in Heart Failure: Novel Protective Lipid Mediators

Volume: 17   Issue: 10
Pp: 1206-1223
Marta Reina-Couto, Luís Vale, Jorge Carvalho, Paulo Bettencourt, António Albino-Teixeira and Teresa Sousa
DOI: 10.2174/1389450117666160101121135

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Emerging Immunotargets in Metastatic Renal Cell Carcinoma

Volume: 17   Issue: 7
Pp: 771-776
John Kucharczyk, Marc R. Matrana, Matteo Santoni, Francesco Massari, Marina Scarpelli, Liang Cheng, Antonio Lopez-Beltran, Stefano Cascinu, Rodolfo Montironi and Moch Holger
DOI: 10.2174/1389450117666151209115753

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Metabotropic Glutamate Receptors in Central Nervous System Diseases

Volume: 17   Issue: 5
Pp: 538-616
Anna V. Golubeva, Rachel D. Moloney, Richard M. O'Connor, Timothy G. Dinan and John F. Cryan
DOI: 10.2174/1389450116666150316224011

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Roles of Apoptosis and Cellular Senescence in Cancer and Aging

Volume: 17   Issue: 4
Pp: 405-415
Claudia Cerella, Cindy Grandjenette, Mario Dicato and Marc Diederich
DOI: 10.2174/1389450116666150202155915

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Targeting the Bone Microenvironment in Metastatic Castration-Resistant Prostate Cancer

Volume: 17   Issue: 3
Pp: 276-289
Pavlos Msaouel, Jose Nahun Galeas, Alejandro Recio Boiles, Ramiro Rancier Ruiz and Michael Koutsilieris
DOI: 10.2174/1389450116666150420143932

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Release of Soluble Ligands for the Activating NKG2D Receptor: One More Immune Evasion Strategy Evolved by HIV-1 ? promotion: free to download

Volume: 17   Issue: 1
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Erica Giuliani, Lia Vassena, Cristina Cerboni and Margherita Doria
DOI: 10.2174/1389450116666150630110329

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Phosphonate Emerging Zinc Binding Group in Matrix Metalloproteinase Inhibitors

Volume: 16   Issue: 14
Pp: 1634-1644
Cristina Campestre, Mariangela Agamennone, Marilena Tauro and Paolo Tortorella
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Impairment of Liver Glycogen Storage in the db/db Animal Model of Type 2 Diabetes: A Potential Target for Future Therapeutics?

Volume: 16   Issue: 10
Pp: 1088-1093
Mitchell A. Sullivan, Brooke E. Harcourt, Ping Xu, Josephine M. Forbes and Robert G. Gilbert
DOI: 10.2174/1389450116666150727123115

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Opportunities for Photoacoustic-Guided Drug Delivery

Volume: 16   Issue: 6
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Jun Xia, Chulhong Kim and Jonathan F. Lovell
DOI: 10.2174/1389450116666150707100328

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Molecular Pathophysiology of Priapism: Emerging Targets

Volume: 16   Issue: 5
Pp: 474-483
Uzoma A. Anele, Belinda F. Morrison and Arthur L. Burnett
DOI: 10.2174/1389450115666141111111842

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Cardiovascular Complications in Inflammatory Bowel Disease

Volume: 16   Issue: 3
Pp: 181-188
Rudolf Schicho, Gunther Marsche and Martin Storr
DOI: 10.2174/1389450116666150202161500

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Molecular Foundations for Personalized Therapy in Prostate Cancer

Volume: 16   Issue: 2
Pp: 103-114
Kurt W. Fisher, Rodolfo Montironi, Antonio Lopez Beltran, Holger Moch, Lisha Wang, Marina Scarpelli, Sean R. Williamson, Michael O. Koch and Liang Cheng
DOI: 10.2174/1389450115666141229154500

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Affinity-Based Methods in Drug-Target Discovery promotion: free to download

Volume: 16   Issue: 1
Pp: 60-76
Gabriela Rylova, Tomas Ozdian, Lakshman Varanasi, Miroslav Soural, Jan Hlavac, Dusan Holub, Petr Dzubak and Marian Hajduch
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Synergistic Activity of the c-Met and Tubulin Inhibitor Tivantinib (ARQ197) with Pemetrexed in Mesothelioma Cells

Volume: 15   Issue: 14
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Leticia G. Leon, Maria Gemelli, Rocco Sciarrillo, Amir Avan, Niccola Funel and Elisa Giovannetti
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Targeting SUMOylation Cascade for Diabetes Management

Volume: 15   Issue: 12
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Dornadula Sireesh, Elango Bhakkiyalakshmi, Kunka Mohanrama Ramkumar, Shanmugakani Rathinakumar, Panneer Selvam Anto Jennifer, Palanisamy Rajaguru and Ramasamy Paulmurugan
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