Current Drug Targets

Francis J. Castellino
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
Dean Emeritus, College of Science
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556
USA

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Open Access Articles

TXNIP in Metabolic Regulation: Physiological Role and Therapeutic Outlook open Access plus

Volume: 18   Issue: 9
Pp: 1095-1103
Naif Mohammad Alhawiti, Saeed Al Mahri, Mohammad Azhar Aziz, Shuja Shafi Malik and Sameer Mohammad*
DOI:10.2174/1389450118666170130145514

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Aspirin Intolerance: Experimental Models for Bed-to-Bench open Access plus

Volume: 17   Issue: 16
Pp: 1963-1970
Masamichi Yamashita
DOI:10.2174/1389450117666161005152327

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Pharmacological Chaperones that Protect Tetrahydrobiopterin Dependent Aromatic Amino Acid Hydroxylases Through Different Mechanisms open Access plus

Volume: 17   Issue: 13
Pp: 1515-1526
Magnus Hole, Ana Jorge-Finnigan, Jarl Underhaug, Knut Teigen and Aurora Martinez
DOI:10.2174/1389450117666160307143512

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Structural and Functional Aspects of Class A Carbapenemases open Access plus

Volume: 17   Issue: 9
Pp: 1006-1028
Thierry Naas, Laurent Dortet and Bogdan I. Iorga
DOI:10.2174/1389450117666160310144501

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Targeted Thromboelastographic (TEG) Blood Component and Pharmacologic Hemostatic Therapy in Traumatic and Acquired Coagulopathy open Access plus

Volume: 17   Issue: 8
Pp: 954-970
Mark Walsh, Stephanie Fritz, Daniel Hake, Michael Son, Sarah Greve, Manar Jbara, Swetha Chitta, Braxton Fritz, Adam Miller, Mary K Bader, Jonathon McCollester, Sophia Binz, Alyson Liew-Spilger, Scott Thomas, Anton Crepinsek, Faisal Shariff, Victoria Ploplis and Francis J. Castellino
DOI:10.2174/1389450117666160310153211

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Insights into a Critical Role of the FOXO3a-FOXM1 Axis in DNA Damage Response and Genotoxic Drug Resistance open Access plus

Volume: 17   Issue: 2
Pp: 164-177
Gabriela Nestal de Moraes, Laura Bella, Stefania Zona, Matthew J. Burton and Eric W.-F. Lam
DOI:10.2174/1389450115666141122211549

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Biologics for Extraintestinal Manifestations of IBD open Access plus

Volume: 15   Issue: 11
Pp: 1064-1073
Stephan R. Vavricka, Michael Scharl, Martin Gubler and Gerhard Rogler
DOI:10.2174/1389450115666140908125453

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Molecular Mechanisms and Treatment of Radiation-Induced Lung Fibrosis open Access plus

Volume: 14   Issue: 11
Pp: 1347-1356
Nian-Hua Ding, Jian Jian Li and Lun-Quan Sun
DOI:10.2174/13894501113149990198

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Acute and Chronic Stress-Induced Disturbances of Microglial Plasticity, Phenotype and Function open Access plus

Volume: 14   Issue: 11
Pp: 1262-1276
Frederick Rohan Walker, Michael Nilsson and Kimberley Jones
DOI:10.2174/13894501113149990208

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Serum S100B Represents a New Biomarker for Mood Disorders open Access plus

Volume: 14   Issue: 11
Pp: 1237-1248
Matthias L. Schroeter, Julia Sacher, Johann Steiner, Peter Schoenknecht and Karsten Mueller
DOI:10.2174/13894501113149990014

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Perioperative Handling of Antiplatelet Drugs. A Critical Appraisal open Access plus

Volume: 14   Issue: 8
Pp: 880-888
Matteo Nicola Dario Di Minno, Marco Milone, Pasquale Mastronardi, Pasquale Ambrosino, Alessandro Di Minno, Alessandro Parolari, Elena Tremoli and Domenico Prisco
DOI:10.2174/1389450111314080008

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Oxidation Inhibits Iron-Induced Blood Coagulation open Access plus

Volume: 14   Issue: 1
Pp: 13-19
Etheresia Pretorius, Janette Bester, Natasha Vermeulen and Boguslaw Lipinski
DOI:10.2174/1389450111314010003

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Tissue-Based Approaches to Study Pharmacodynamic Endpoints in Early Phase Oncology Clinical Trials open Access plus

Volume: 13   Issue: 12
Pp: 1525-1534
Joo Ern Ang, Stan Kaye and Udai Banerji
DOI:10.2174/138945012803530062

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Overcoming Drug Resistance and Treating Advanced Prostate Cancer open Access plus

Volume: 13   Issue: 10
Pp: 1308-1323
Julius Semenas, Cinzia Allegrucci, Stephen A. Boorjian, Nigel P. Mongan and Jenny Liao Persson
DOI:10.2174/138945012802429615

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Molecular Pathology of Pancreatic Cancer: From Bench-to-Bedside Translation open Access plus

Volume: 13   Issue: 6
Pp: 744-752
Vincenzo Corbo, Giampaolo Tortora and Aldo Scarpa
DOI:10.2174/138945012800564103

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Novel and Viable Acetylcholinesterase Target Site for Developing Effective and Environmentally Safe Insecticides open Access plus

Volume: 13   Issue: 4
Pp: 471-482
Yuan-Ping Pang, Stephen Brimijoin, David W. Ragsdale, Kun Yan Zhu and Robert Suranyi
DOI:10.2174/138945012799499703

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Architecture and Conservation of the Bacterial DNA Replication Machinery, an Underexploited Drug Target open Access plus

Volume: 13   Issue: 3
Pp: 352-372
Andrew Robinson, Rebecca J. Causer and Nicholas E. Dixon
DOI:10.2174/138945012799424598

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Vaccines and Other Immunological Approaches for Cancer Immunoprevention open Access plus

Volume: 12   Issue: 13
Pp: 1957-1973
Pier-Luigi Lollini, Giordano Nicoletti, Lorena Landuzzi, Federica Cavallo, Guido Forni, Carla De Giovanni and Patrizia Nanni
DOI:10.2174/138945011798184146

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The Professional Phagocyte Dictyostelium discoideum as a Model Host for Bacterial Pathogens open Access plus

Volume: 12   Issue: 7
Pp: 942-954
Salvatore Bozzaro and Ludwig Eichinger
DOI:10.2174/138945011795677782

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Host-Pathogen Interactions Made Transparent with the Zebrafish Model open Access plus

Volume: 12   Issue: 7
Pp: 1000-1017
Annemarie H. Meijer and Herman P. Spaink
DOI:10.2174/138945011795677809

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Properties and Therapeutic Potential of Transient Receptor Potential Channels with Putative Roles in Adversity: Focus on TRPC5, TRPM2 and TRPA1 open Access plus

Volume: 12   Issue: 5
Pp: 724-736
L. H. Jiang, N. Gamper and D. J. Beech
DOI:10.2174/138945011795378568

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The Molecular Mechanisms of Glucocorticoids-Mediated Neutrophil Survival open Access plus

Volume: 12   Issue: 4
Pp: 556-562
Arash S. Saffar, Heather Ashdown and Abdelilah S. Gounni
DOI:10.2174/138945011794751555

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Heme Oxygenase-1 in Tumor Biology and Therapy open Access plus

Volume: 11   Issue: 12
Pp: 1551-1570
Halina Was, Jozef Dulak and Alicja Jozkowicz
DOI:10.2174/1389450111009011551

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Involvement of the Toxic AGEs (TAGE)-RAGE System in the Pathogenesis of Diabetic Vascular Complications: A Novel Therapeutic Strategy open Access plus

Volume: 11   Issue: 11
Pp: 1468-1482
Masayoshi Takeuchi, Jun-ichi Takino and Sho-ichi Yamagishi
DOI:10.2174/1389450111009011468

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The Macrophage Stimulating Protein/Ron Pathway as a Potential Therapeutic Target to Impede Multiple Mechanisms Involved in Breast Cancer Progression open Access plus

Volume: 11   Issue: 9
Pp: 1157-1168
Kelsi L. Kretschmann, Henok Eyob, Saundra S. Buys and Alana L. Welm
DOI:10.2174/138945010792006825

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MicroRNA-21: From Cancer to Cardiovascular Disease open Access plus

Volume: 11   Issue: 8
Pp: 926-935
Virginija Jazbutyte and Thomas Thum
DOI:10.2174/138945010791591403

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Activated Protein C and Acute Kidney Injury: Selective Targeting of PAR-1 open Access plus

Volume: 10   Issue: 12
Pp: 1212-1226
Akanksha Gupta, Mark D. Williams, William L. Macias, Bruce A. Molitoris and Brian W. Grinnell
DOI:10.2174/138945009789753291

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Inflammatory Systemic Biomarkers in Setting Acute Coronary Syndromes - Effects of the Diurnal Variation open Access plus

Volume: 10   Issue: 10
Pp: 1001-1008
A. Dominguez-Rodriguez, P. Abreu-Gonzalez and J. C. Kaski
DOI:10.2174/138945009789577963

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Atherosclerosis and Arterial Blood Pressure in Mice open Access plus

Volume: 8   Issue: 11
Pp: 1181-1189
Hong Lu, Lisa A. Cassis and Alan Daugherty
DOI:10.2174/138945007782403829

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GSK3 at the Edge: Regulation of Developmental Specification and Cell Polarization open Access plus

Volume: 7   Issue: 11
Pp: 1411-1419
Leung Kim and Alan R. Kimmel
DOI:10.2174/1389450110607011411

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