Current Drug Targets


Francis J. Castellino
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
Dean Emeritus, College of Science
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556


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Most Cited Article

AMPK as a New Attractive Therapeutic Target for Disease Prevention: The Role of Dietary Compounds AMPK and Disease Prevention

Volume:17   Issue:8
Pp: 865-889
Massimiliano Gasparrini, Francesca Giampieri, Josè M. Alvarez Suarez, Luca Mazzoni, Tamara Y. Forbes Hernandez, Josè L. Quiles, Pedro Bullon and Maurizio Battino
DOI: 10.2174/1573399811666150615150235

B1-Metallo-β-Lactamases: Where Do We Stand?

Volume:17   Issue:9
Pp: 1029-1050
Maria F. Mojica, Robert A. Bonomo and Walter Fast
DOI: 10.2174/1389450116666151001105622

Diabetes and Complications: Cellular Signaling Pathways, Current Understanding and Targeted Therapies

Volume:17   Issue:11
Pp: 1309-1328
Krishna A. Adeshara, Arundhati G. Diwan and Rashmi S. Tupe
DOI: 10.2174/1389450117666151209124007

Oxidative Stress and Antioxidants in Neurological Diseases: Is There Still Hope?

Volume:18   Issue:6
Pp: 705-718
Andreia Neves Carvalho*, Omidreza Firuzi, Maria Joao Gama, Jack van Horssen and Luciano Saso
DOI: 10.2174/1389450117666160401120514

Virological and Clinical Response to Interferon-Free Regimens in Patients with HCV-Related Mixed Cryoglobulinemia: Preliminary Results of a Prospective Pilot Study

Volume:18   Issue:7
Pp: 772-785
Laura Gragnani, Alessia Piluso, Teresa Urraro, Alessio Fabbrizzi, Elisa Fognani, Luisa Petraccia, Alessandro Genovesi, Lidia Giubilei, Jessica Ranieri, Cristina Stasi, Monica Monti and Anna Linda Zignego*
DOI: 10.2174/1389450117666160208145432

Structural and Functional Aspects of Class A Carbapenemases open access plus

Volume:17   Issue:9
Pp: 1006-1028
Thierry Naas, Laurent Dortet and Bogdan I. Iorga
DOI: 10.2174/1389450117666160310144501

Targeting Cystathionine Beta-Synthase Misfolding in Homocystinuria by Small Ligands: State of the Art and Future Directions

Volume:17   Issue:13
Pp: 1455-1470
Tomas Majtan, Angel L. Pey, June Ereño-Orbea, Luis Alfonso Martínez-Cruz and Jan P. Kraus
DOI: 10.2174/1389450117666160302094910

Sirtuins: Possible Clinical Implications in Cardio and Cerebrovascular Diseases

Volume:18   Issue:4
Pp: 473-484
Valeria Conti, Maurizio Forte, Graziamaria Corbi, Giusy Russomanno, Luigi Formisano, Alessandro Landolfi, Viviana Izzo, Amelia Filippelli, Carmine Vecchione and Albino Carrizzo
DOI: 10.2174/1389450116666151019095903

Biology, Epidemiology, Clinical Aspects of Hepatocellular Carcinoma and the Role of Sorafenib

Volume:17   Issue:7
Pp: 783-799
Gianluigi Mazzoccoli, Luca Miele, Jude Oben, Antonio Grieco and Manlio Vinciguerra
DOI: 10.2174/1389450117666151209120831