Current Drug Targets


Francis J. Castellino
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
Dean Emeritus, College of Science
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556


Most Cited Article

AMPK as a New Attractive Therapeutic Target for Disease Prevention: The Role of Dietary Compounds AMPK and Disease Prevention

Volume:17   Issue:8
Pp: 865-889
Massimiliano Gasparrini, Francesca Giampieri, Josè M. Alvarez Suarez, Luca Mazzoni, Tamara Y. Forbes Hernandez, Josè L. Quiles, Pedro Bullon and Maurizio Battino
DOI: 10.2174/1573399811666150615150235

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B1-Metallo-β-Lactamases: Where Do We Stand?

Volume:17   Issue:9
Pp: 1029-1050
Maria F. Mojica, Robert A. Bonomo and Walter Fast
DOI: 10.2174/1389450116666151001105622

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Oxidative Stress and Antioxidants in Neurological Diseases: Is There Still Hope?

Volume:18   Issue:6
Pp: 705-718
Andreia Neves Carvalho*, Omidreza Firuzi, Maria Joao Gama, Jack van Horssen and Luciano Saso
DOI: 10.2174/1389450117666160401120514

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Virological and Clinical Response to Interferon-Free Regimens in Patients with HCV-Related Mixed Cryoglobulinemia: Preliminary Results of a Prospective Pilot Study

Volume:18   Issue:7
Pp: 772-785
Laura Gragnani, Alessia Piluso, Teresa Urraro, Alessio Fabbrizzi, Elisa Fognani, Luisa Petraccia, Alessandro Genovesi, Lidia Giubilei, Jessica Ranieri, Cristina Stasi, Monica Monti and Anna Linda Zignego*
DOI: 10.2174/1389450117666160208145432

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Structural and Functional Aspects of Class A Carbapenemases open access plus

Volume:17   Issue:9
Pp: 1006-1028
Thierry Naas, Laurent Dortet and Bogdan I. Iorga
DOI: 10.2174/1389450117666160310144501

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Targeting Cystathionine Beta-Synthase Misfolding in Homocystinuria by Small Ligands: State of the Art and Future Directions

Volume:17   Issue:13
Pp: 1455-1470
Tomas Majtan, Angel L. Pey, June Ereño-Orbea, Luis Alfonso Martínez-Cruz and Jan P. Kraus
DOI: 10.2174/1389450117666160302094910

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Sirtuins: Possible Clinical Implications in Cardio and Cerebrovascular Diseases

Volume:18   Issue:4
Pp: 473-484
Valeria Conti, Maurizio Forte, Graziamaria Corbi, Giusy Russomanno, Luigi Formisano, Alessandro Landolfi, Viviana Izzo, Amelia Filippelli, Carmine Vecchione and Albino Carrizzo
DOI: 10.2174/1389450116666151019095903

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Biology, Epidemiology, Clinical Aspects of Hepatocellular Carcinoma and the Role of Sorafenib

Volume:17   Issue:7
Pp: 783-799
Gianluigi Mazzoccoli, Luca Miele, Jude Oben, Antonio Grieco and Manlio Vinciguerra
DOI: 10.2174/1389450117666151209120831

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Targeting the BRCA1/2 Tumor Suppressors promotion: free to download

Volume:15   Issue:1
Pp: 17-31
Eliot M. Rosen and Michael J. Pishvaian
DOI: 10.2174/1389450114666140106095432

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Therapeutic Targeting of Cancers with Loss of PTEN Function promotion: free to download

Volume:15   Issue:1
Pp: 65-79
Lloye M. Dillon and Todd W. Miller
DOI: 10.2174/1389450114666140106100909

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