Current Drug Targets

Editor-in-Chief:

Francis J. Castellino
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
Dean Emeritus, College of Science
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556
USA

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Most Cited Article

Cytochrome P450 Structure, Function and Clinical Significance: A Review promotion: free to download

Volume:19   Issue:1
Pp: 38-54
Palrasu Manikandan and Siddavaram Nagini*
DOI: 10.2174/1389450118666170125144557

Cyclin-Dependent Kinase 2 in Cellular Senescence and Cancer. A Structural and Functional Review

Volume:20   Issue:7
Pp: 716-726
Priscylla Andrade Volkart, Gabriela Bitencourt-Ferreira, André Arigony Souto* and Walter Filgueira de Azevedo *
DOI: 10.2174/1389450120666181204165344

PARP Inhibitor Drugs in the Treatment of Breast, Ovarian, Prostate and Pancreatic Cancers: An Update of Clinical Trials promotion: free to download

Volume:19   Issue:1
Pp: 21-37
Dalia Kamel*, Christopher Gray, Jagdeep Singh Walia and Vikaash Kumar*
DOI: 10.2174/1389450118666170711151518

Recent Advances in Protein Tyrosine Phosphatase 1B Targeted Drug Discovery for Type II Diabetes and Obesity

Volume:19   Issue:5
Pp: 551-575
Neelesh Maheshwari, Chandrabose Karthikeyan, Piyush Trivedi and N.S. Hari Narayana Moorthy*
DOI: 10.2174/1389450118666170222143739

Flavonoids and its Neuroprotective Effects on Brain Ischemia and Neurodegenerative Diseases

Volume:19   Issue:14
Pp: 1710-1720
Manish Putteeraj, Wei Ling Lim, Seong Lin Teoh and Mohamad Fairuz Yahaya*
DOI: 10.2174/1389450119666180326125252

Stimuli-responsive Smart Liposomes in Cancer Targeting

Volume:19   Issue:3
Pp: 259-270
Ankit Jain and Sanjay K. Jain*
DOI: 10.2174/1389450117666160208144143

Clinical, Prognostic and Therapeutic Significance of Heat Shock Proteins in Cancer

Volume:19   Issue:13
Pp: 1478-1490
Jasleen Saini and Pushpender Kumar Sharma*
DOI: 10.2174/1389450118666170823121248

Nanoparticles in Cancer Treatment: Opportunities and Obstacles

Volume:19   Issue:14
Pp: 1696-1709
Rajendra Awasthi*, Ariane Roseblade, Philip Michael Hansbro, Michael John Rathbone, Kamal Dua and Mary Bebawy*
DOI: 10.2174/1389450119666180326122831

Insights into the Targeting Potential of Thymoquinone for Therapeutic Intervention Against Triple-negative Breast Cancer promotion: free to download

Volume:19   Issue:1
Pp: 70-80
Md Abul Barkat, Harshita, Javed Ahmad, Mohammad Ahmed Khan*, Sarwar Beg* and Farhan Jalees Ahmad*
DOI: 10.2174/1389450118666170612095959

GRP78 Influences Chemoresistance and Prognosis in Cancer

Volume:19   Issue:6
Pp: 701-708
Jenifer B. Gifford and Reginald Hill*
DOI: 10.2174/1389450118666170615100918

Antitumor Activity of Polysaccharides: An Overview promotion: free to download

Volume:19   Issue:1
Pp: 89-96
Ling Chen and Gangliang Huang*
DOI: 10.2174/1389450118666170704143018

CDK9 as an Appealing Target for Therapeutic Interventions

Volume:20   Issue:4
Pp: 453-464
Shirin Eyvazi, Mohammad Saeid Hejazi, Homan Kahroba, Mozghan Abasi, Reza Eghdam Zamiri and Vahideh Tarhriz*
DOI: 10.2174/1389450119666181026152221

Blood Eosinophils as Biomarkers to Drive Treatment Choices in Asthma and COPD open access plus

Volume:19   Issue:16
Pp: 1882-1896
Konstantinos Kostikas, Caterina Brindicci and Francesco Patalano*
DOI: 10.2174/1389450119666180212120012

Metformin, A New Era for an Old Drug in the Treatment of Immune Mediated Disease?

Volume:19   Issue:8
Pp: 945-959
Mark Schuiveling, Nadia Vazirpanah, Timothy R.D.J. Radstake, Maili Zimmermann* and Jasper C.A. Broen*
DOI: 10.2174/1389450118666170613081730

Nanocarrier Based Advances in Drug Delivery to Tumor: An Overview

Volume:19   Issue:13
Pp: 1498-1518
Ankit Jain, Romi Kumari, Ankita Tiwari, Amit Verma, Amita Tripathi, Akanksha Shrivastava and Sanjay K. Jain*
DOI: 10.2174/1389450119666180131105822

Current Status and Perspectives on Pharmacologic Therapy for Abdominal Aortic Aneurysm open access plus

Volume:19   Issue:11
Pp: 1265-1275
Koichi Yoshimura*, Noriyasu Morikage, Shizuka Nishino-Fujimoto, Akira Furutani, Bungo Shirasawa and Kimikazu Hamano
DOI: 10.2174/1389450119666171227223331

LncRNA HOTAIR Polymorphisms Association with Cancer Susceptibility in Different Tumor Types

Volume:19   Issue:10
Pp: 1220-1226
Gerardo Botti, Francesca Collina, Giosuè Scognamiglio, Gabriella Aquino, Margherita Cerrone, Giuseppina Liguori, Vincenzo Gigantino, Maria Gabriella Malzone and Monica Cantile*
DOI: 10.2174/1389450118666170622091940

Macrophage Polarization as a Therapeutic Target in Myocardial Infarction

Volume:19   Issue:6
Pp: 651-662
Yuanyuan Cheng and Jianhui Rong*
DOI: 10.2174/1389450118666171031115025

Complexation of Bioelements and Toxic Metals by Polyphenolic Compounds – Implications for Health

Volume:19   Issue:14
Pp: 1612-1638
Sylwia Borowska*, Malgorzata Michalina Brzoska* and Michal Tomczyk
DOI: 10.2174/1389450119666180403101555

Epigenetic Biomarkers for Risk Assessment of Particulate Matter Associated Lung Cancer

Volume:19   Issue:10
Pp: 1127-1147
Arpit Bhargava, Neha Bunkar, Aniket Aglawe, Kailash Chand Pandey, Rajnarayan Tiwari, Koel Chaudhury, Irina Yu Goryacheva and Pradyumna Kumar Mishra*
DOI: 10.2174/1389450118666170911114342

Efficacy and Safety of Serotonin Receptor Ligands in the Treatment of Irritable Bowel Syndrome: A Review

Volume:19   Issue:15
Pp: 1774-1781
Agata Binienda, Martin Storr, Jakub Fichna and Maciej Salaga*
DOI: 10.2174/1389450119666171227225408

Main Isoflavones Found in Dietary Sources as Natural Anti-inflammatory Agents

Volume:19   Issue:7
Pp: 841-853
Corina Danciu*, Stefana Avram, Ioana Zinuca Pavel, Roxana Ghiulai, Cristina Adriana Dehelean, Alexa Ersilia, Daliana Minda, Cristina Petrescu*, Elena-Alina Moaca and Codruta Soica
DOI: 10.2174/1389450118666171109150731

Versatility of Cancer Associated Fibroblasts: Commendable Targets for Anti-tumor Therapy

Volume:19   Issue:13
Pp: 1573-1588
Ghulam Jilany Khan*, Li Sun, Sara Khan, Shengtao Yuan* and He Nongyue*
DOI: 10.2174/1389450119666180219124439

Alcohol Addiction- Metabotropic Glutamate Receptor Subtype 5 and its Ligands: How They All Come Together?

Volume:19   Issue:8
Pp: 907-915
Jaya Kumar*, Zalina Ismail, Nurul Hazwani Hatta, Najwa Baharuddin, Hermizi Hapidin, Yvonne-Tee Get Bee, Ernie Yap and Rashidi Mohamed Pakri Mohamed
DOI: 10.2174/1389450118666170511144302