Abstract
In the pathogenesis of depressive symptoms the neurotransmitter serotonin plays an important role - although the underlining mechanisms are still not clear. The synthesis of serotonin is dependent on the availability of tryptophan - an amino acid that is linked to the immune system by its catabolism via the enzyme indoleamine-2,3-dioxygenase (IDO). Based on this connection research approaches addressing different clinical conditions with depressive symptoms and immunological involvement have been considered. This review provides an overview on the latest research in the field.
Keywords: Depression, tryptophan, immune activation, IDO activity, somatic diseases, pregnancy, cytokine treatment
Current Drug Metabolism
Title: IDO and Clinical Conditions Associated with Depressive Symptoms
Volume: 8 Issue: 3
Author(s): Claudia Kohl and B. Sperner-Unterweger
Affiliation:
Keywords: Depression, tryptophan, immune activation, IDO activity, somatic diseases, pregnancy, cytokine treatment
Abstract: In the pathogenesis of depressive symptoms the neurotransmitter serotonin plays an important role - although the underlining mechanisms are still not clear. The synthesis of serotonin is dependent on the availability of tryptophan - an amino acid that is linked to the immune system by its catabolism via the enzyme indoleamine-2,3-dioxygenase (IDO). Based on this connection research approaches addressing different clinical conditions with depressive symptoms and immunological involvement have been considered. This review provides an overview on the latest research in the field.
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Cite this article as:
Kohl Claudia and Sperner-Unterweger B., IDO and Clinical Conditions Associated with Depressive Symptoms, Current Drug Metabolism 2007; 8 (3) . https://dx.doi.org/10.2174/138920007780362572
DOI https://dx.doi.org/10.2174/138920007780362572 |
Print ISSN 1389-2002 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5453 |
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