The Effect of Statins on Postprandial Lipemia

Title: The Effect of Statins on Postprandial Lipemia

Volume: 8 Issue: 4

Author(s): Genovefa D. Kolovou, Katherine K. Anagnostopoulou, Klelia D. Salpea, Stella S. Daskalopoulou and Dimitri P. Mikhailidis

Affiliation:

Keywords: Postprandial lipemia, statins, triglycerides, coronary heart disease

Abstract: Several studies showed that postprandial plasma triglyceride (TG) concentrations are higher in patients with coronary heart disease. TG-rich lipoprotein remnants accumulated in the postprandial state are involved in atherogenesis and in events leading to thrombosis. Lipid lowering drugs, such as 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors (statins) are of significant benefit in the primary and secondary prevention of atherosclerosis. Statins can decrease total cholesterol and low density lipoprotein cholesterol as well as TG concentrations and improve postprandial lipoprotein metabolism. Since abnormal postprandial lipemia is associated with pathological conditions, its treatment is relevant. This review considers the effect of statins on postprandial lipemia.

Cite this article as:

Kolovou D. Genovefa, Anagnostopoulou K. Katherine, Salpea D. Klelia, Daskalopoulou S. Stella and Mikhailidis P. Dimitri, The Effect of Statins on Postprandial Lipemia, Current Drug Targets 2007; 8 (4) . https://dx.doi.org/10.2174/138945007780362809