Abstract
The heating of different parallel arrays in domestic ovens offers the possibility to perform multiple reactions in one irradiation experiment, blending the advantages of microwave heating technology and parallel chemistry. However, they are usually performed without an appropriate temperature control; thus, reproducibility becomes a major issue limiting the application of such reactions. This is exemplified when working at a different scales or using different instruments. For the first time a typical solvent-free reaction described in a domestic oven has been reproduced in monomode reactor, scaled up in a controlled multimode oven and reproduced in parallel, 24 reactions were carried out in a well plate. Parallel reactions were performed in a Weflon® multiwell plate to assure identical conditions for each individual reaction. As many reactions under microwave irradiation have been performed in solvent-free conditions, this result opens new possibilities in reproducibility, scalability and combinatorial chemistry and permits to take advantage of many synthetic procedures described in domestic ovens.
Keywords: multimode microwave ovens, Nitrile N-Oxide 1, HPLC, MicroSYNTH labstation multimode microwave oven (MILESTONE), Monomode microwave irradiations
Combinatorial Chemistry & High Throughput Screening
Title: Reproducibility and Scalability of Solvent-Free Microwave-Assisted Reactions:From Domestic Ovens to Controllable Parallel Applications
Volume: 10 Issue: 3
Author(s): Angel Diaz-Ortiz, Antonio de la Hoz, Jesus Alcazar, Jose Ramon Carrillo, Maria Antonia Herrero, Alberto Fontana and Juan de Mata Munoz
Affiliation:
Keywords: multimode microwave ovens, Nitrile N-Oxide 1, HPLC, MicroSYNTH labstation multimode microwave oven (MILESTONE), Monomode microwave irradiations
Abstract: The heating of different parallel arrays in domestic ovens offers the possibility to perform multiple reactions in one irradiation experiment, blending the advantages of microwave heating technology and parallel chemistry. However, they are usually performed without an appropriate temperature control; thus, reproducibility becomes a major issue limiting the application of such reactions. This is exemplified when working at a different scales or using different instruments. For the first time a typical solvent-free reaction described in a domestic oven has been reproduced in monomode reactor, scaled up in a controlled multimode oven and reproduced in parallel, 24 reactions were carried out in a well plate. Parallel reactions were performed in a Weflon® multiwell plate to assure identical conditions for each individual reaction. As many reactions under microwave irradiation have been performed in solvent-free conditions, this result opens new possibilities in reproducibility, scalability and combinatorial chemistry and permits to take advantage of many synthetic procedures described in domestic ovens.
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Cite this article as:
Diaz-Ortiz Angel, de la Hoz Antonio, Alcazar Jesus, Ramon Carrillo Jose, Antonia Herrero Maria, Fontana Alberto and de Mata Munoz Juan, Reproducibility and Scalability of Solvent-Free Microwave-Assisted Reactions:From Domestic Ovens to Controllable Parallel Applications, Combinatorial Chemistry & High Throughput Screening 2007; 10 (3) . https://dx.doi.org/10.2174/138620707780126679
DOI https://dx.doi.org/10.2174/138620707780126679 |
Print ISSN 1386-2073 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5402 |
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