Abstract
Medial vascular calcification in an increasingly recognized problem in patients with diabetes and patients with chronic kidney disease. Calcification of the media is associated with significant morbidity and mortality. The phenotypic and the molecular fingerprints of medial calcification in patients with diabetes and patients with chronic kidney disease are strikingly similar. While disturbances in divalent ion homeostasis have been proposed to play a role in calcification of the media in patients with chronic kidney disease, patients with diabetes have an apparently intact bone and mineral metabolism. Chronic kidney disease as well as diabetes are now recognized as pro-inflammatory states. This review will explore the pathobiology of medial vascular calcification, review the evidence for diabetes and chronic kidney disease as pro-inflammatory states, and discuss the role of inflammation as a mechanistic link that explains the similarities in phenotypic and molecular characteristics of medial calcification in patients with chronic kidney disease and patients with diabetes mellitus.
Keywords: Vascular calcification, diabetes mellitus, chronic kidney disease, inflammation, TNF-alpha
Cardiovascular & Hematological Disorders-Drug Targets
Title: Medial Vascular Calcification in Diabetes Mellitus and Chronic Kidney Disease: The Role of Inflammation
Volume: 7 Issue: 1
Author(s): Ziyad Al-Aly
Affiliation:
Keywords: Vascular calcification, diabetes mellitus, chronic kidney disease, inflammation, TNF-alpha
Abstract: Medial vascular calcification in an increasingly recognized problem in patients with diabetes and patients with chronic kidney disease. Calcification of the media is associated with significant morbidity and mortality. The phenotypic and the molecular fingerprints of medial calcification in patients with diabetes and patients with chronic kidney disease are strikingly similar. While disturbances in divalent ion homeostasis have been proposed to play a role in calcification of the media in patients with chronic kidney disease, patients with diabetes have an apparently intact bone and mineral metabolism. Chronic kidney disease as well as diabetes are now recognized as pro-inflammatory states. This review will explore the pathobiology of medial vascular calcification, review the evidence for diabetes and chronic kidney disease as pro-inflammatory states, and discuss the role of inflammation as a mechanistic link that explains the similarities in phenotypic and molecular characteristics of medial calcification in patients with chronic kidney disease and patients with diabetes mellitus.
Export Options
About this article
Cite this article as:
Al-Aly Ziyad, Medial Vascular Calcification in Diabetes Mellitus and Chronic Kidney Disease: The Role of Inflammation, Cardiovascular & Hematological Disorders-Drug Targets 2007; 7 (1) . https://dx.doi.org/10.2174/187152907780059047
DOI https://dx.doi.org/10.2174/187152907780059047 |
Print ISSN 1871-529X |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-4063 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Thrombophilia in Pregnancy: Maternal and Fetal Implications
Current Women`s Health Reviews The Role of Insertion Allele of Angiotensin Converting Enzyme Gene in Higher Endurance Efficiency and Some Aspects of Pathophysiological and Drug Effects
Current Medicinal Chemistry Recent Developments of C-Aryl Glucoside SGLT2 Inhibitors
Current Medicinal Chemistry The Multiple Roles of XBP1 in Regulation of Glucose and Lipid Metabolism
Current Protein & Peptide Science Graphical Abstracts
Current Diabetes Reviews New Inhibitors of Glycogen Phosphorylase as Potential Antidiabetic Agents
Current Medicinal Chemistry Molecular Mechanisms, Proteinopathies and Therapeutic Strategies in Neurodegenerative Disorders
Current Genomics Cyclin-Dependent Kinase 4/6 (Cdk4/6) Inhibitors: Perspectives in Cancer Therapy and Imaging
Mini-Reviews in Medicinal Chemistry Jumping on the Train of Personalized Medicine: A Primer for Non-Geneticist Clinicians: Part 2. Fundamental Concepts in Genetic Epidemiology
Current Psychiatry Reviews Revascularization vs. Optimal Medical Therapy in Women with NSTE-ACS
Current Pharmaceutical Design Structural Basis of Infectious and Non-Infectious Amyloids
Current Alzheimer Research Prevalence, Diagnosis, and Treatment with 3 Different Statins of Non-alcoholic Fatty Liver Disease/Non-alcoholic Steatohepatitis in Military Personnel. Do Genetics Play a Role?
Current Vascular Pharmacology Baru Nut Intake and Resistance Training Practice have Potential to Reduce the Cardiometabolic Risk Factors in Type 2 Diabetes
Current Nutrition & Food Science Identification of New Pancreatic Beta Cell Targets for In Vivo Imaging by a Systems Biology Approach
Current Pharmaceutical Design Clinical Proteomics in Cancer Research
Current Proteomics Biology of Circulating Nucleic Acids and Possible Roles in Diagnosis and Treatment in Diabetes and Cancer
Infectious Disorders - Drug Targets RAGE: A Potential Target for Aβ-Mediated Cellular Perturbation in Alzheimers Disease
Current Molecular Medicine Determinants of Paraoxonase 1 Status: Genes, Drugs and Nutrition
Current Medicinal Chemistry Editorial
Current Diabetes Reviews Physical Function and Exercise in Older Patients with Cardiovascular and Respiratory Conditions
Current Pharmaceutical Design