Abstract
Sequential activation of kinases (protein kinase cascades) is a general mechanism of signal transduction in many cellular processes. Several related intracellular signaling cascades have been found and characterized in the last 25 years known as mitogen-activated protein kinase (MAPK) signaling cascades. These cascades cooperate in transmitting extracellular signals to their intracellular targets and thus initiate cellular processes such as proliferation, differentiation, development, stress- and inflammatory response, and apoptosis. Each of these signaling cascades consists of protein kinases that sequentially in several steps activate each other by phosphorylation. MAPKs are ubiquitously expressed but regulate a variety of biological responses depending on the cell type. Modulating the function of MAPK pathways by small molecules therefore requires a profound understanding of how MAPKs are integrated in various signaling networks.
Keywords: MAPK, MAPKAPK, ERK, p38, JNK, TPL2, TTP, gene targeting
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Title: The ERK and p38MAPK Pathways as Targets for Anti-Inflammatory Therapy
Volume: 6 Issue: 1
Author(s): Edward Hitti and Alexey Kotlyarov
Affiliation:
Keywords: MAPK, MAPKAPK, ERK, p38, JNK, TPL2, TTP, gene targeting
Abstract: Sequential activation of kinases (protein kinase cascades) is a general mechanism of signal transduction in many cellular processes. Several related intracellular signaling cascades have been found and characterized in the last 25 years known as mitogen-activated protein kinase (MAPK) signaling cascades. These cascades cooperate in transmitting extracellular signals to their intracellular targets and thus initiate cellular processes such as proliferation, differentiation, development, stress- and inflammatory response, and apoptosis. Each of these signaling cascades consists of protein kinases that sequentially in several steps activate each other by phosphorylation. MAPKs are ubiquitously expressed but regulate a variety of biological responses depending on the cell type. Modulating the function of MAPK pathways by small molecules therefore requires a profound understanding of how MAPKs are integrated in various signaling networks.
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Cite this article as:
Hitti Edward and Kotlyarov Alexey, The ERK and p38MAPK Pathways as Targets for Anti-Inflammatory Therapy, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 2007; 6 (1) . https://dx.doi.org/10.2174/187152307779939741
DOI https://dx.doi.org/10.2174/187152307779939741 |
Print ISSN 1871-5230 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-614X |
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