Abstract
Cardiovascular diseases are the major cause of morbidity and mortality in both men and women in industrially developed countries. These disorders may result from impaired angiogenesis, particularly in response to hypoxia. Despite many limitations, gene therapy is still emerging as a potential alternative for patients who are not candidates for traditional revascularization procedures, like angioplasty or vein grafts. This review focuses on recent approaches in the development of new gene delivery vectors, with great respect to newly discovered AAV serotypes and their modified forms. Moreover, some new cardiovascular gene therapy strategies have been highlighted, such as combination of different angiogenic growth factors or simultaneous application of genes and progenitor cells in order to obtain stable and functional blood vessels in ischemic tissue.
Keywords: Angiogenesis, vascular endothelial growth factor, heme oxygenase, hypoxia inducible factor-1, superoxide dismutase, endothelial progenitor cells
Current Gene Therapy
Title: New Vectors and Strategies for Cardiovascular Gene Therapy
Volume: 7 Issue: 1
Author(s): Agnieszka Jazwa, Alicja Jozkowicz and Jozef Dulak
Affiliation:
Keywords: Angiogenesis, vascular endothelial growth factor, heme oxygenase, hypoxia inducible factor-1, superoxide dismutase, endothelial progenitor cells
Abstract: Cardiovascular diseases are the major cause of morbidity and mortality in both men and women in industrially developed countries. These disorders may result from impaired angiogenesis, particularly in response to hypoxia. Despite many limitations, gene therapy is still emerging as a potential alternative for patients who are not candidates for traditional revascularization procedures, like angioplasty or vein grafts. This review focuses on recent approaches in the development of new gene delivery vectors, with great respect to newly discovered AAV serotypes and their modified forms. Moreover, some new cardiovascular gene therapy strategies have been highlighted, such as combination of different angiogenic growth factors or simultaneous application of genes and progenitor cells in order to obtain stable and functional blood vessels in ischemic tissue.
Export Options
About this article
Cite this article as:
Jazwa Agnieszka, Jozkowicz Alicja and Dulak Jozef, New Vectors and Strategies for Cardiovascular Gene Therapy, Current Gene Therapy 2007; 7 (1) . https://dx.doi.org/10.2174/156652307779940243
DOI https://dx.doi.org/10.2174/156652307779940243 |
Print ISSN 1566-5232 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5631 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Diabetes Mellitus and Vascular Endothelial Dysfunction: Current Perspectives
Current Vascular Pharmacology Biologic Therapy and Treatment Options in Diabetic Retinopathy with Diabetic Macular Edema
Current Drug Safety Heat Shock Proteins: Therapeutic Perspectives in Inflammatory Disorders
Recent Patents on Inflammation & Allergy Drug Discovery Association Between Polycystic Ovary Syndrome and Metabolic Syndrome
Current Medicinal Chemistry Lipid-based Self-Adjuvanting Vaccines
Current Drug Delivery Targeting the Endocannabinod System to Limit Myocardial and Cerebral Ischemic and Reperfusion Injury
Current Pharmaceutical Biotechnology In Silico Studies in Drug Research Against Neurodegenerative Diseases
Current Neuropharmacology Alteration of the Beta-Adrenergic Signaling Pathway in Human Heart Failure
Current Pharmaceutical Biotechnology Fundamental Concepts of the Angiogenic Process
Current Molecular Medicine The Pharmacogenomics of Anti-Platelet Intervention (PAPI) Study: Variation in Platelet Response to Clopidogrel and Aspirin
Current Vascular Pharmacology Atrial Remodeling and Novel Pharmacological Strategies for Antiarrhythmic Therapy in Atrial Fibrillation
Current Medicinal Chemistry Effects of Music Therapy on Psychological Symptoms and Heart Rate Variability in Patients with Dementia. A Pilot Study
Current Aging Science Cerebrovascular Diseases in HIV-Infected Patients
Current HIV Research Mesoionic Oxatriazoles (MOTA): NO-Donating Characteristics and Pharmacology
Current Pharmaceutical Design Sedation in PACU: The Role of Propofol
Current Drug Targets Dietary Carbohydrates - Requirement and Recommendation in the Human Diet
Current Nutrition & Food Science Biologic Therapy in Psoriasis: Safety Profile
Current Drug Safety Organophosphorus Compounds: Intervention in Mechanisms of Signal Transduction Relevant to Proliferative, Immunological and Circulatory Disorders
Current Medicinal Chemistry Nitric Oxide is a Central Common Metabolite in Vascular Dysfunction Associated with Diseases of Human Pregnancy
Current Vascular Pharmacology The Molecular Concept of Atheromatous Plaques
Current Drug Targets