Abstract
Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) are bioactive lysophospholipid mediators with a wide variety of biological actions. G-protein-coupled receptors for LPA and S1P have been identified, and physiological and pathological significances of the lysophospholipids and their receptors are under intensive investigation. Furthermore, specific agonists and antagonists for the receptors have been developed for clinical applications. However, mechanisms underlying their production have not yet been fully elucidated. Recently, autotaxin, an exo-phosphodiesterase implicated in tumor cell migration, has been discovered as lysophospholipase D that produces LPA and S1P from lysophosphatidylcholine and sphingosylphosphorylcholine, respectively. In this article, I reviewed the structure, expression, substrate specificity, enzymatic function, specific inhibitors and pathophysiological significances of lysophospholipase D/autotaxin.
Keywords: Lysophospholipase D, autotoxin, lysophosphatidic acid, sphingosine 1-phosphate, lysophosphatidylcholine, sphingosylphosphorylcholine, tumor metastasis
Current Enzyme Inhibition
Title: Lysophospholipase D/Autotaxin in Lysophospholipid Biology
Volume: 3 Issue: 1
Author(s): Dong-Soon Im
Affiliation:
Keywords: Lysophospholipase D, autotoxin, lysophosphatidic acid, sphingosine 1-phosphate, lysophosphatidylcholine, sphingosylphosphorylcholine, tumor metastasis
Abstract: Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) are bioactive lysophospholipid mediators with a wide variety of biological actions. G-protein-coupled receptors for LPA and S1P have been identified, and physiological and pathological significances of the lysophospholipids and their receptors are under intensive investigation. Furthermore, specific agonists and antagonists for the receptors have been developed for clinical applications. However, mechanisms underlying their production have not yet been fully elucidated. Recently, autotaxin, an exo-phosphodiesterase implicated in tumor cell migration, has been discovered as lysophospholipase D that produces LPA and S1P from lysophosphatidylcholine and sphingosylphosphorylcholine, respectively. In this article, I reviewed the structure, expression, substrate specificity, enzymatic function, specific inhibitors and pathophysiological significances of lysophospholipase D/autotaxin.
Export Options
About this article
Cite this article as:
Im Dong-Soon, Lysophospholipase D/Autotaxin in Lysophospholipid Biology, Current Enzyme Inhibition 2007; 3 (1) . https://dx.doi.org/10.2174/157340807779815440
DOI https://dx.doi.org/10.2174/157340807779815440 |
Print ISSN 1573-4080 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6662 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Protein-protein Interactions: Network Analysis and Applications in Drug Discovery
Current Pharmaceutical Design Clinical Impact of Gene Expression Profiling on Oncology Diagnosis, Prognosis, and Treatment
Combinatorial Chemistry & High Throughput Screening A Review on Metal Nanoparticles from Medicinal Plants: Synthesis, Characterization and Applications
Nanoscience & Nanotechnology-Asia STAT Signaling and Cell Function
Current Genomics Early Palliative Care in Advanced Oncologic and Non-Oncologic Chronic Diseases: A Systematic Review of Literature
Reviews on Recent Clinical Trials Pyrimidine Nucleosides in Molecular PET Imaging of Tumor Proliferation
Current Medicinal Chemistry Towards a Gene Therapy Clinical Trial for Epidermolysis Bullosa
Reviews on Recent Clinical Trials Role of α7-Nicotinic Acetylcholine Receptor in Normal and Cancer Stem Cells
Current Drug Targets Prognostic Value of Pre- and Posttreatment PET/CT Parameters in Patients Diagnosed with Advanced Stage NSCLC
Current Medical Imaging In Vitro Inhibition Effect and Molecular Docking Study of Curcumin, Resveratrol, and Quercetin on Human Erythrocyte Glutathione Transferase
Current Enzyme Inhibition Current Application of Quantum Dots (QD) in Cancer Therapy: A Review
Mini-Reviews in Medicinal Chemistry Methionine-Independent Translation Initiation from Naturally Occurring Non-AUG Codons
Current Chemical Biology KRAS Mutation Testing of Colorectal Cancer for Anti-EGFR Therapy: Dogmas Versus Evidence
Current Cancer Drug Targets Anticancer Drugs in Liposomal Nanodevices: A Target Delivery for a Targeted Therapy
Current Topics in Medicinal Chemistry Inhibitory Role of Resveratrol in the Development of Profibrogenesis and Fibrosis Mechanisms
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) The Stem Cell Niche as a Pharmaceutical Target for Prevention of Skeletal Metastases
Anti-Cancer Agents in Medicinal Chemistry Outlook on Epigenetic Therapeutic Approaches for Treatment of Gastric Cancer
Current Cancer Drug Targets Antitumor Effects of Celastrol and Semi-Synthetic Derivatives
Mini-Reviews in Organic Chemistry Targeting Gene Therapy for Prostate Cancer
Current Pharmaceutical Design On the Role of Rab5 in Cell Migration
Current Molecular Medicine