Abstract
The nasal route is a potential alternative route for systemic availability of drugs restricted to intravenous administration, such as peptide and protein drugs and vaccines. This route is also advisable for drugs undergoing extensive first pass effect .Besides this, intranasal route has also been successfully exploited for bypassing the blood brain barrier [BBB] and subsequently delivering drug molecules to central nervous system [CNS]. The present article highlights the advantages, barriers, physicochemical factors and formulation related parameters affecting the nasal drug delivery. It also includes a note on nasal absorption enhancers. Also, the applications of nasal route for delivery of peptides and proteins, non-peptide drugs, vaccines and drug molecules to CNS have been summarized in depth.
Keywords: Nasal route, nasal absorption enhancers, peptide, protein drugs, vaccines, central nervous system
Current Drug Therapy
Title: Nasal Drug Delivery System-Factors Affecting and Applications
Volume: 2 Issue: 1
Author(s): Kisan R. Jadhav, Manoj N. Gambhire, Ishaque M. Shaikh, Vilarsrao J. Kadam and Sambjahi S. Pisal
Affiliation:
Keywords: Nasal route, nasal absorption enhancers, peptide, protein drugs, vaccines, central nervous system
Abstract: The nasal route is a potential alternative route for systemic availability of drugs restricted to intravenous administration, such as peptide and protein drugs and vaccines. This route is also advisable for drugs undergoing extensive first pass effect .Besides this, intranasal route has also been successfully exploited for bypassing the blood brain barrier [BBB] and subsequently delivering drug molecules to central nervous system [CNS]. The present article highlights the advantages, barriers, physicochemical factors and formulation related parameters affecting the nasal drug delivery. It also includes a note on nasal absorption enhancers. Also, the applications of nasal route for delivery of peptides and proteins, non-peptide drugs, vaccines and drug molecules to CNS have been summarized in depth.
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Cite this article as:
Jadhav R. Kisan, Gambhire N. Manoj, Shaikh M. Ishaque, Kadam J. Vilarsrao and Pisal S. Sambjahi, Nasal Drug Delivery System-Factors Affecting and Applications, Current Drug Therapy 2007; 2 (1) . https://dx.doi.org/10.2174/157488507779422374
DOI https://dx.doi.org/10.2174/157488507779422374 |
Print ISSN 1574-8855 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3903 |
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