Abstract
The use of dopamine agonists has increased due to their effectiveness in treating symptoms of Parkinson disease (PD) and Restless Leg Syndrome (RLS). Recently, rare but serious adverse effects have been linked to DA agonists, including sudden somnolence, cardiac valvulopathy and repetitive behaviors. Clinicians are in a difficult situation because of insufficient information to make clear recommendations to patients. We review these controversies, discuss pathophysiology and report current practices in light of such uncertainty.
Keywords: Dopamine agonists, adverse effects, sleep attacks, valvulopathy, punding, dopamine dysregulation syndrome
Current Drug Therapy
Title: Controversies of Dopamine Agonists: Somnolence, Cardiac Valvulopathy and Repetitive Behaviors
Volume: 2 Issue: 1
Author(s): Samay Jain and Cheryl H. Waters
Affiliation:
Keywords: Dopamine agonists, adverse effects, sleep attacks, valvulopathy, punding, dopamine dysregulation syndrome
Abstract: The use of dopamine agonists has increased due to their effectiveness in treating symptoms of Parkinson disease (PD) and Restless Leg Syndrome (RLS). Recently, rare but serious adverse effects have been linked to DA agonists, including sudden somnolence, cardiac valvulopathy and repetitive behaviors. Clinicians are in a difficult situation because of insufficient information to make clear recommendations to patients. We review these controversies, discuss pathophysiology and report current practices in light of such uncertainty.
Export Options
About this article
Cite this article as:
Jain Samay and Waters H. Cheryl, Controversies of Dopamine Agonists: Somnolence, Cardiac Valvulopathy and Repetitive Behaviors, Current Drug Therapy 2007; 2 (1) . https://dx.doi.org/10.2174/157488507779422347
DOI https://dx.doi.org/10.2174/157488507779422347 |
Print ISSN 1574-8855 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3903 |
Call for Papers in Thematic Issues
Novel Therapeutic Approaches and Biomarkers for Chronic Kidney Disease (CKD)
The thematic issue on "Novel Therapeutic Approaches and Biomarkers for CKD" aims to provide a comprehensive exploration of cutting-edge strategies for the management of chronic kidney disease (CKD). This issue will delve into emerging therapeutic targets, focusing on critical aspects such as podocyte injury, endothelial dysfunction, and tubulointerstitial fibrosis, which ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Subject Index To Volume 12
Current Pharmaceutical Design Cardiovascular Health vs Cardiovascular Risk A 2011 Update: Cardiovascular Risk Stratification, the Basis to Reach Therapeutic Goals
Current Hypertension Reviews A Multidisciplinary Atrial Fibrillation Clinic
Current Cardiology Reviews Combination Therapy of Inhaled Corticosteroids and Long-Acting β2- Adrenergics In Management of Patients with Chronic Obstructive Pulmonary Disease
Current Pharmaceutical Design Biology and Clinical Relevance of Mannose-Binding Lectin
Drug Design Reviews - Online (Discontinued) Arterial Accelerated Aging in Dialysis Patients: The Clinical Impact of Vascular Calcification
Current Vascular Pharmacology Editorial (Thematic Issue: Novel Insights into the Role of Anesthetics and Opioids in Organ or Tissue Protection)
Current Pharmaceutical Design Immunomodulation Mechanism of Antidepressants: Interactions between Serotonin/Norepinephrine Balance and Th1/Th2 Balance
Current Neuropharmacology HIF Prolyl 4-Hydroxylases and their Potential as Drug Targets
Current Pharmaceutical Design A Review of Premature Frailty in HIV-Infected Persons; Another Manifestation of HIV-Related Accelerated Aging
Current Aging Science MicroRNA Regulation in Cardiovascular Disease
Current Drug Targets Unequivocal Role of Pyrazine Ring in Medicinally Important Compounds: A Review
Mini-Reviews in Medicinal Chemistry Dyslipidemia, Metabolic Syndrome and Vascular Disease Among Asian Indians
Vascular Disease Prevention (Discontinued) Monocytes and Macrophages as Cellular Targets in Liver Fibrosis
Inflammation & Allergy - Drug Targets (Discontinued) Angiogenesis Inhibitors: Current & Future Directions
Current Pharmaceutical Design The Effect of Flavonoids on Allergic Diseases
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Targeting Platelet-Neutrophil Interactions in Giant-Cell Arteritis
Current Pharmaceutical Design Development of Meat and Poultry Products Enriched with n-3 PUFAs and their Functional Role
Current Nutrition & Food Science Fabry Disease Cardiomyopathy: from Genes to Clinical Manifestations
Current Pharmaceutical Biotechnology Phytochemical Therapies in Vascular Functioning: A Molecular Approach
Current Vascular Pharmacology