Abstract
Influenza is a disease that deeply affects millions of people every year. There has not been any drug effective against all strains. Neuraminidase (NA) is the major surface glycoprotein of the influenza virus, which possesses critical enzymatic activity and has been considered as a suitable target for designing agents against influenza viruses. Here we review the structure and functions of this enzyme and touch upon the structureactivity relationship (SAR) of existing influenza neuraminidase inhibitors (NAIs).
Keywords: Influenza virus, Neuraminidase, Structure, Functions, Neuraminidase inhibitors, Structure-activity relationship
Current Medicinal Chemistry
Title: Structure and Functions of Influenza Virus Neuraminidase
Volume: 14 Issue: 1
Author(s): Jianzhi Gong, Wenfang Xu and Jie Zhang
Affiliation:
Keywords: Influenza virus, Neuraminidase, Structure, Functions, Neuraminidase inhibitors, Structure-activity relationship
Abstract: Influenza is a disease that deeply affects millions of people every year. There has not been any drug effective against all strains. Neuraminidase (NA) is the major surface glycoprotein of the influenza virus, which possesses critical enzymatic activity and has been considered as a suitable target for designing agents against influenza viruses. Here we review the structure and functions of this enzyme and touch upon the structureactivity relationship (SAR) of existing influenza neuraminidase inhibitors (NAIs).
Export Options
About this article
Cite this article as:
Gong Jianzhi, Xu Wenfang and Zhang Jie, Structure and Functions of Influenza Virus Neuraminidase, Current Medicinal Chemistry 2007; 14 (1) . https://dx.doi.org/10.2174/092986707779313444
DOI https://dx.doi.org/10.2174/092986707779313444 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
Current advances in inherited cardiomyopathy
Describe in detail all novel advances in multimodality imaging related to inherited cardiomyopathy diagnosis and prognosis. Shed light to deeper phenotypic characterization. Acknowledge recent advances in genetics, genomics and precision medicineread more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Molecular Docking: Challenges, Advances and its Use in Drug Discovery Perspective
Current Drug Targets Cholestasis During Pregnancy: Aetiopathogenesis, Foetal-Maternal Repercussions and Pharmacological Treatments
Current Women`s Health Reviews Cardiac Side Effects of Chemotherapy: State of Art and Strategies for a Correct Management
Current Vascular Pharmacology A Multi-dimensional Review on Severe Acute Respiratory Syndrome Coronavirus-2
Current Pharmaceutical Biotechnology Substrates, Inhibitors and Activators of P-glycoprotein: Candidates for Radiolabeling and Imaging Perspectives
Current Topics in Medicinal Chemistry Sodium Carbonate Sesquiperhydrate (2Na2CO3-3H2O2) Catalysed One-pot Synthesis of Biologically Dynamic Novel Substituted Spirooxirane Dicarboxamides
Current Catalysis Design, Synthesis and Mode of Action of Some New 2-(4'-aminophenyl) benzothiazole Derivatives as Potent Antimicrobial Agents
Letters in Drug Design & Discovery Treatment of Hypertensive Complications in Pregnancy
Current Pharmaceutical Design Drug Design Strategies for the Discovery of Novel Anticonvulsants Concerned with Four Site Binding Pharmacophoric Model Studies
Central Nervous System Agents in Medicinal Chemistry Azole Antimycotics - A Highway to New Drugs or a Dead End?
Current Medicinal Chemistry Meet the Guest Editor
Combinatorial Chemistry & High Throughput Screening A Review on Catastrophic Evolution of SARS-CoV to SARS-CoV2: A Global Pandemic
Coronaviruses Vitamin D Deficiency and Acute Lung Injury
Inflammation & Allergy - Drug Targets (Discontinued) Revealing Potential Binding Affinity of FDA Approved Therapeutics Targeting Main Protease (3CLpro) in Impairing Novel Coronavirus (SARSCoV- 2) Replication that Causes COVID-19
Coronaviruses Genetic-TLBO Algorithm for Power System Stabilizer
Current Signal Transduction Therapy Potential of Nanocarriers in Genetic Immunization
Recent Patents on Drug Delivery & Formulation Development of Heparanase Inhibitors for Anti-Cancer Therapy
Current Medicinal Chemistry Occupational Exposure and Respiratory Tract Infections –At Risk Workers in the International Context
Current Respiratory Medicine Reviews Process Development Strategies in Plant Molecular Farming
Current Pharmaceutical Biotechnology The Clustered DNA Lesions – Types, Pathways of Repair and Relevance to Human Health
Current Medicinal Chemistry