Abstract
The present study was aimed at developing and exploring the use of PEGylated poly (propylene imine) dendritic architecture for the delivery of an anti-tuberculosis drug, rifampicin. For this study, PEGylated poly(propylene imine) dendritic architecture was synthesized and loaded with rifampicin. Various physicochemical and physiological parameters UV, IR, NMR, TEM, DSC, drug entrapment, drug release and hemolytic toxicity of both PEGylated and non- PEGylated systems were determined and compared. The PEGylation of the systems was found to have increased their drug-loading capacity, reduced their drug release rate and hemolytic toxicity. The systems were found suitable for prolonged delivery of rifampicin.
Keywords: Dendrimers, PEGylation, micelles, rifampicin, prolonged release
Current Drug Delivery
Title: PEGylated Dendritic Architecture for Development of a Prolonged Drug Delivery System for an Antitubercular Drug
Volume: 4 Issue: 1
Author(s): P. Vijayaraj Kumar, Hrushikesh Agashe, Tathagata Dutta and Narendra K. Jain
Affiliation:
Keywords: Dendrimers, PEGylation, micelles, rifampicin, prolonged release
Abstract: The present study was aimed at developing and exploring the use of PEGylated poly (propylene imine) dendritic architecture for the delivery of an anti-tuberculosis drug, rifampicin. For this study, PEGylated poly(propylene imine) dendritic architecture was synthesized and loaded with rifampicin. Various physicochemical and physiological parameters UV, IR, NMR, TEM, DSC, drug entrapment, drug release and hemolytic toxicity of both PEGylated and non- PEGylated systems were determined and compared. The PEGylation of the systems was found to have increased their drug-loading capacity, reduced their drug release rate and hemolytic toxicity. The systems were found suitable for prolonged delivery of rifampicin.
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Vijayaraj Kumar P., Agashe Hrushikesh, Dutta Tathagata and Jain K. Narendra, PEGylated Dendritic Architecture for Development of a Prolonged Drug Delivery System for an Antitubercular Drug, Current Drug Delivery 2007; 4 (1) . https://dx.doi.org/10.2174/156720107779314794
DOI https://dx.doi.org/10.2174/156720107779314794 |
Print ISSN 1567-2018 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5704 |
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