Current Cancer Drug Targets

Ruiwen Zhang 
Texas Tech University Health Sciences Center
1300 Coulter Drive
Amarillo, TX 79106
USA

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Open Access Articles

HR+, HER2– Advanced Breast Cancer and CDK4/6 Inhibitors: Mode of Action, Clinical Activity, and Safety Profiles open Access plus

Volume: 17   Issue: 7
Pp: 637-649
Sarah L. Sammons, Donna L. Topping and Kimberly L. Blackwell
DOI:10.2174/1568009617666170330120452

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Advances in Synergistic Combinations of Chinese Herbal Medicine for the Treatment of Cancer open Access plus

Volume: 16   Issue: 4
Pp: 346-356
Xue-Qing Hu, Yang Sun, Eric Lau, Ming Zhao and Shi-Bing Su
DOI:10.2174/1568009616666151207105851

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A Comprehensive Outline of Trastuzumab Resistance Biomarkers in HER2 Overexpressing Breast Cancer open Access plus

Volume: 15   Issue: 8
Pp: 665-683
Otília Menyhart, Libero Santarpia and Balazs Gyorffy
DOI:10.2174/156800961508151001101742

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Cancer Stem Cells in Solid and Liquid Tissues of Breast Cancer Patients: Characterization and Therapeutic Perspectives open Access plus

Volume: 15   Issue: 3
Pp: 256-269
Rena Chiotaki, Hara Polioudaki and Panayiotis A. Theodoropoulos
DOI:10.2174/1568009615666150211102503

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Platycodin D Induces Tumor Growth Arrest by Activating FOXO3a Expression in Prostate Cancer in vitro and in vivo open Access plus

Volume: 14   Issue: 9
Pp: 860-871
Rui Zhou, Zongliang Lu, Kai Liu, Jing Guo, Jie Liu, Yong Zhou, Jian Yang, Mantian Mi and Hongxia Xu
DOI:10.2174/1568009614666141128104642

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Pleiotropic Role of HSF1 in Neoplastic Transformation open Access plus

Volume: 14   Issue: 2
Pp: 144-155
Natalia Vydra, Agnieszka Toma and Wieslawa Widlak
DOI:10.2174/1568009614666140122155942

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MicroRNAs as Critical Regulators Involved in Regulating Epithelial- Mesenchymal Transition open Access plus

Volume: 13   Issue: 9
Pp: 935-944
Xiaodi Zhao, Yuanyuan Lu, Yongzhan Nie and Daiming Fan
DOI:10.2174/15680096113136660099

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Unveiling the Role of Nuclear Transport in Epithelial-to-Mesenchymal Transition open Access plus

Volume: 13   Issue: 9
Pp: 906-914
Asfar S. Azmi
DOI:10.2174/15680096113136660096

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β-Catenin Knockdown in Liver Tumor Cells by a Cell Permeable Gamma Guanidine-based Peptide Nucleic Acid open Access plus

Volume: 13   Issue: 8
Pp: 867-878
Evan Delgado, Raman Bahal, Jing Yang, Jung M. Lee, Danith H Ly and Satdarshan P. S. Monga
DOI:10.2174/15680096113139990081

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Signal Transduction in Human Cutaneous Melanoma and Target Drugs open Access plus

Volume: 13   Issue: 8
Pp: 843-866
Anatoly B. Uzdensky, Svetlana V. Demyanenko and Mikhail Y. Bibov
DOI:10.2174/1568009611313080004

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Use of Single Nucleotide Polymorphism Array Technology to Improve the Identification of Chromosomal Lesions in Leukemia open Access plus

Volume: 13   Issue: 7
Pp: 791-810
Ilaria Iacobucci, Annalisa Lonetti, Cristina Papayannidis and Giovanni Martinelli
DOI:10.2174/15680096113139990089

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Autophagy in Chronic Myeloid Leukaemia: Stem Cell Survival and Implication in Therapy open Access plus

Volume: 13   Issue: 7
Pp: 724-734
Gudmundur V. Helgason, Arunima Mukhopadhyay, Maria Karvela, Paolo Salomoni, Bruno Calabretta and Tessa L. Holyoake
DOI:10.2174/15680096113139990088

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New Insights Into Biology of Chronic Myeloid Leukemia: Implications in Therapy open Access plus

Volume: 13   Issue: 7
Pp: 711-723
Michele Cea, Antonia Cagnetta, Alessio Nencioni, Marco Gobbi and Franco Patrone
DOI:10.2174/15680096113139990085

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Unmet Needs in Ovarian Cancer: Dividing Histologic Subtypes to Exploit Novel Targets and Pathways open Access plus

Volume: 13   Issue: 6
Pp: 698-707
Vijaya Galic, Robert L. Coleman and Thomas J. Herzog
DOI:10.2174/15680096113139990002

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Targeting Hypoxia for Sensitization of Tumors to Radio- and Chemotherapy open Access plus

Volume: 13   Issue: 6
Pp: 670-685
Khaled Ghattass, Rana Assah, Marwan El-Sabban and Hala Gali-Muhtasib
DOI:10.2174/15680096113139990004

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Anti-inflammatory Phytochemicals for Chemoprevention of Colon Cancer open Access plus

Volume: 13   Issue: 5
Pp: 542-557
Venkateshwar Madka and Chinthalapally V. Rao
DOI:10.2174/15680096113139990036

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miRNAs in Cancer Prevention and Treatment and as Molecular Targets for Natural Product Anticancer Agents open Access plus

Volume: 13   Issue: 5
Pp: 519-541
Biyun Qian, Subhasree A. Nag, Yuliang Su, Sukesh Voruganti, Jiang-Jiang Qin, Ruiwen Zhang and William C. S. Cho
DOI:10.2174/15680096113139990031

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VEGF in Tumor Progression and Targeted Therapy open Access plus

Volume: 13   Issue: 4
Pp: 423-443
Vladimir P. Chekhonin, Sergey A. Shein, Anna A. Korchagina and Olga I. Gurina
DOI:10.2174/15680096113139990074

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Nanomedicines as Cancer Therapeutics: Current Status open Access plus

Volume: 13   Issue: 4
Pp: 362-378
Sohail Akhter, Iqbal Ahmad, Mohammad Zaki Ahmad, Farshad Ramazani, Anjali Singh, Ziyaur Rahman, Farhan Jalees Ahmad, Gert Storm and Robbert J. Kok
DOI:10.2174/1568009611313040002

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P-glycoprotein Inhibition as a Therapeutic Approach for Overcoming Multidrug Resistance in Cancer: Current Status and Future Perspectives open Access plus

Volume: 13   Issue: 3
Pp: 326-346
Ziyad Binkhathlan and Afsaneh Lavasanifar
DOI:10.2174/15680096113139990076

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Targeting Tyrosine Kinase Receptors in Hepatocellular Carcinoma open Access plus

Volume: 13   Issue: 3
Pp: 300-312
Jordi Muntane, Angel J. De la Rosa, Fernando Docobo, Rocio Garcia-Carbonero and Francisco J. Padillo
DOI:10.2174/15680096113139990075

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Novel Approaches for Molecular Targeted Therapy of Breast Cancer: Interfering with PI3K/AKT/mTOR Signaling open Access plus

Volume: 13   Issue: 2
Pp: 188-204
Thomas W. Grunt and Gabriella L. Mariani
DOI:10.2174/1568009611313020008

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Current Status and Future Perspectives of PI3K and mTOR Inhibitor as Anticancer Drugs in Breast Cancer open Access plus

Volume: 13   Issue: 2
Pp: 175-187
Xiaobei Zhang, Xi-ru Li and Jin Zhang
DOI:10.2174/1568009611313020007

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Cancer Stem Cell as a Potential Therapeutic Target in Hepatocellular Carcinoma open Access plus

Volume: 12   Issue: 9
Pp: 1081-1094
Roberta W.C. Pang and Ronnie T.P. Poon
DOI:10.2174/15680096112091081

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Targeted Therapy for Liver Cancer: Updated Review in 2012 open Access plus

Volume: 12   Issue: 9
Pp: 1062-1072
Masatoshi Kudo
DOI:10.2174/15680096112091062

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Scope of Nanotechnology-based Radiation Therapy and Thermotherapy Methods in Cancer Treatment open Access plus

Volume: 12   Issue: 8
Pp: 998-1015
Mohamadreza K. Bakht, Mahdi Sadeghi, Milad Pourbaghi-Masouleh and Claudio Tenreiro
DOI:10.2174/156800912803251216

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Membrane Transporters as Determinants of the Pharmacology of Platinum Anticancer Drugs open Access plus

Volume: 12   Issue: 8
Pp: 962-986
Johnson J. Liu, Jun Lu and Mark J. McKeage
DOI:10.2174/156800912803251199

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A Comprehensive Overview of Targeted Therapy in Metastatic Renal Cell Carcinoma open Access plus

Volume: 12   Issue: 7
Pp: 857-872
Z. Mihaly, Z. Sztupinszki, P. Surowiak and B. Gyorffy
DOI:10.2174/156800912802429265

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Promises and Challenges of MicroRNA-based Treatment of Multiple Myeloma open Access plus

Volume: 12   Issue: 7
Pp: 838-846
P. Tagliaferri, M. Rossi, M. T. Di Martino, N. Amodio, E. Leone, A. Gulla, A. Neri and P. Tassone
DOI:10.2174/156800912802429355

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MicroRNAs in the Pathobiology of Multiple Myeloma open Access plus

Volume: 12   Issue: 7
Pp: 823-837
Marta Lionetti, Luca Agnelli, Luigia Lombardi, Pierfrancesco Tassone and Antonino Neri
DOI:10.2174/156800912802429274

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Mouse Models as a Translational Platform for the Development of New Therapeutic Agents in Multiple Myeloma open Access plus

Volume: 12   Issue: 7
Pp: 814-822
P. Tassone, P. Neri, R. Burger, M. T. Di Martino, E. Leone, N. Amodio, M. Caraglia and P. Tagliaferri
DOI:10.2174/156800912802429292

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Molecular Targets for the Treatment of Multiple Myeloma open Access plus

Volume: 12   Issue: 7
Pp: 757-767
Marco Rossi, Maria Teresa Di Martino, Eugenio Morelli, Marzia Leotta, Antonietta Rizzo, Anna Grimaldi, Gabriella Misso, Pierfrancesco Tassone and Michele Caraglia
DOI:10.2174/156800912802429300

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Emerging Roles for Modulation of microRNA Signatures in Cancer Chemoprevention open Access plus

Volume: 12   Issue: 6
Pp: 716-740
K. Neelakandan, P. Babu and S. Nair
DOI:10.2174/156800912801784875

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High CXCR4 Expression Correlates with Sunitinib Poor Response in Metastatic Renal Cancer open Access plus

Volume: 12   Issue: 6
Pp: 693-702
C. D'Alterio, L. Portella, A. Ottaiano, M. Rizzo, G. Carteni, S. Pignata, G. Facchini, S. Perdona, G. Di Lorenzo, R. Autorino, R. Franco, A. La Mura, O. Nappi, G. Castello and S. Scala
DOI:10.2174/156800912801784820

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Two Novel GPER Agonists Induce Gene Expression Changes and Growth Effects in Cancer Cells open Access plus

Volume: 12   Issue: 5
Pp: 531-542
R. Lappano, C. Rosano, M. F. Santolla, M. Pupo, E. M. De Francesco, P. De Marco, M. Ponassi, A. Spallarossa, A. Ranise and M. Maggiolini
DOI:10.2174/156800912800673284

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Emerging Therapies in Chronic Myeloid Leukemia open Access plus

Volume: 12   Issue: 5
Pp: 458-470
J. Gora-Tybor
DOI:10.2174/156800912800673202

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An Epigenetic Approach to Pancreatic Cancer Treatment: The Prospective Role of Histone Deacetylase Inhibitors open Access plus

Volume: 12   Issue: 4
Pp: 439-452
Nicola Tinari, Michele De Tursi, Antonino Grassadonia, Marinella Zilli, Liborio Stuppia, Stefano Iacobelli and Clara Natoli
DOI:10.2174/156800912800190884

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Genetic Variants in Genes Involved in Mechanisms of Chemoresistance to Anticancer Drugs open Access plus

Volume: 12   Issue: 4
Pp: 402-438
J. J.G. Marin, O. Briz, M. J. Monte, A. G. Blazquez and R. I.R. Macias
DOI:10.2174/156800912800190875

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Targeting EGFR for Treatment of Glioblastoma: Molecular Basis to Overcome Resistance open Access plus

Volume: 12   Issue: 3
Pp: 197-209
T. E. Taylor, F. B. Furnari and W. K. Cavenee
DOI:10.2174/156800912799277557

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Nanotech Revolution for the Anti-Cancer Drug Delivery through Blood- Brain-Barrier open Access plus

Volume: 12   Issue: 3
Pp: 186-196
M. Caraglia, G. De Rosa, G. Salzano, D. Santini, M. Lamberti, P. Sperlongano, A. Lombardi, A. Abbruzzese and R. Addeo
DOI:10.2174/156800912799277421

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Anticancer Drugs Aimed at E6 and E7 Activity in HPV-Positive Cervical Cancer open Access plus

Volume: 12   Issue: 2
Pp: 170-184
S. Tan, E. G.E. de Vries, A. G.J. van der Zee and S. de Jong
DOI:10.2174/156800912799095135

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Adding to the Mix: Fibroblast Growth Factor and Platelet-Derived Growth Factor Receptor Pathways as Targets in Non – small Cell Lung Cancer open Access plus

Volume: 12   Issue: 2
Pp: 107-123
S. A. Kono, L. E. Heasley, R. C. Doebele and D. R. Camidge
DOI:10.2174/156800912799095144

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Targeting ATP7A to Increase the Sensitivity of Neuroblastoma Cells to Retinoid Therapy open Access plus

Volume: 11   Issue: 7
Pp: 826-836
B. B. Cheung and G. M. Marshall
DOI:10.2174/156800911796798968

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Strategies for Overcoming Inherent and Acquired Resistance to EGFR Inhibitors by Targeting Downstream Effectors in the RAS/PI3K Pathway open Access plus

Volume: 10   Issue: 8
Pp: 824-833
A. J. Weickhardt, N. C. Tebbutt and J. M. Mariadason
DOI:10.2174/156800910793357961

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Dexamethasone Synergizes with Lenalidomide to Inhibit Multiple Myeloma Tumor Growth, But Reduces Lenalidomide-Induced Immunomodulation of T and NK Cell Function open Access plus

Volume: 10   Issue: 2
Pp: 155-167
A. K. Gandhi, J. Kang, L. Capone, A. Parton, L. Wu, L. H. Zhang, D. Mendy, A. Lopez-Girona, T. Tran, L. Sapinoso, W. Fang, S. Xu, G. Hampton, J. B. Bartlett and P. Schafer
DOI:10.2174/156800910791054239

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Potential Uses of MicroRNA in Lung Cancer Diagnosis, Prognosis, and Therapy open Access plus

Volume: 9   Issue: 4
Pp: 572-594
Qi Zhao Wang, William Xu, Nagy Habib and Ruian Xu
DOI:10.2174/156800909788486731

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S100A8 and S100A9 Overexpression Is Associated with Poor Pathological Parameters in Invasive Ductal Carcinoma of the Breast open Access plus

Volume: 8   Issue: 4
Pp: 243-252
Kazumori Arai, Sachiko Takano, Takumi Teratani, Yasuhiro Ito, Toshihiro Yamada and Ryushi Nozawa
DOI:10.2174/156800908784533445

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Nutritional Modulation of Terminal End Buds: Its Relevance to Breast Cancer Prevention open Access plus

Volume: 7   Issue: 5
Pp: 465-474
Leena Hilakivi-Clarke
DOI:10.2174/156800907781386641

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Ribonucleotide Reductase Inhibitors and Future Drug Design open Access plus

Volume: 6   Issue: 5
Pp: 409-431
J. Shao, B. Zhou, Bernard Chu and Y. Yen
DOI:10.2174/156800906777723949

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Liposomal Muramyl Tripeptide Phosphatidylethanolamine: Targeting and Activating Macrophages for Adjuvant Treatment of Osteosarcoma open Access plus

Volume: 6   Issue: 2
Pp: 123-133
A. Nardin, M. L. Lefebvre, K. Labroquere, O. Faure and J. P. Abastado
DOI:10.2174/156800906776056473

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