Effects of Progesterone on Sleep: A Possible Pharmacological Treatment for Sleep-Breathing Disorders?

Title: Effects of Progesterone on Sleep: A Possible Pharmacological Treatment for Sleep-Breathing Disorders?

Volume: 13 Issue: 29

Author(s): M. L. Andersen, L. R. A. Bittencourt, I. B. Antunes and S. Tufik

Affiliation:

Keywords: Progesterone, sleep, sleep apnea, breathing, hormonal control

Abstract: Progesterone is present in a wide spectrum of biological activity within a variety of tissues. This hormone is also known to affect reproduction, sleep quality, respiration, mood, appetite, learning, memory and sexual activity. Progesterone exerts a sleep induction or hypnotic effect and is a potent respiratory stimulant that has been associated to a decrease in the number of central and obstructive sleep apnea episodes in men. The literature also contains a substantial amount of data on the effect of apnea in women with obesityhypoventilation during menopause. This review attempts to outline the specific role of progesterone in normal sleep and breathing as well as its possible therapeutic effects in the treatment of sleep-disordered breathing.

Cite this article as:

Andersen L. M., A. Bittencourt R. L., Antunes B. I. and Tufik S., Effects of Progesterone on Sleep: A Possible Pharmacological Treatment for Sleep-Breathing Disorders?, Current Medicinal Chemistry 2006; 13 (29) . https://dx.doi.org/10.2174/092986706779026200