Abstract
Osteopontin (OPN) is a chemokine like phosphorylated glycoprotein that plays important role in cancer progression. Extensive research from various laboratories has demonstrated the likely role of OPN in regulating the cell signaling that ultimately controls tumor growth and metastasis. Several earlier reports indicated that OPN is associated with various cancers; but its functional role in carcinogenesis is still not well defined. Besides the role of OPN in tumor biology, several studies have demonstrated the pathophysiological role of OPN in diverse biological events. This review will focus on recent advances in understanding the molecular mechanism by which OPN regulates a series of signaling cascades through activation of various kinases and transcription factors that ultimately control the expression of downstream effector genes, which contribute to tumor progression and angiogenesis in vitro and animal models. We will also provide evidences that suggest the enhanced expression of OPN is not only associated with several tumor types, but its level of expression is directly correlated to various stages of the clinical specimens of breast and prostate cancers. These studies may be useful for identifying novel OPN-based therapeutic approach for the treatment of cancer.
Keywords: Osteopontin, cell signaling, tumor progression, metastasis, angiogenesis
Current Molecular Medicine
Title: The Multifaceted Roles of Osteopontin in Cell Signaling, Tumor Progression and Angiogenesis
Volume: 6 Issue: 8
Author(s): Goutam Chakraborty, Shalini Jain, Reeti Behera, Mansoor Ahmed, Priyanka Sharma, Vinit Kumar and Gopal C. Kundu
Affiliation:
Keywords: Osteopontin, cell signaling, tumor progression, metastasis, angiogenesis
Abstract: Osteopontin (OPN) is a chemokine like phosphorylated glycoprotein that plays important role in cancer progression. Extensive research from various laboratories has demonstrated the likely role of OPN in regulating the cell signaling that ultimately controls tumor growth and metastasis. Several earlier reports indicated that OPN is associated with various cancers; but its functional role in carcinogenesis is still not well defined. Besides the role of OPN in tumor biology, several studies have demonstrated the pathophysiological role of OPN in diverse biological events. This review will focus on recent advances in understanding the molecular mechanism by which OPN regulates a series of signaling cascades through activation of various kinases and transcription factors that ultimately control the expression of downstream effector genes, which contribute to tumor progression and angiogenesis in vitro and animal models. We will also provide evidences that suggest the enhanced expression of OPN is not only associated with several tumor types, but its level of expression is directly correlated to various stages of the clinical specimens of breast and prostate cancers. These studies may be useful for identifying novel OPN-based therapeutic approach for the treatment of cancer.
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Cite this article as:
Chakraborty Goutam, Jain Shalini, Behera Reeti, Ahmed Mansoor, Sharma Priyanka, Kumar Vinit and Kundu C. Gopal, The Multifaceted Roles of Osteopontin in Cell Signaling, Tumor Progression and Angiogenesis, Current Molecular Medicine 2006; 6 (8) . https://dx.doi.org/10.2174/156652406779010803
DOI https://dx.doi.org/10.2174/156652406779010803 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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