Abstract
GSK3 is a multifunctional protein kinase that is pivotal for the regulation of metabolism, the cytoskeleton, and gene expression. Multicellular eukaryotes utilize GSK3 as a molecular switch to specify distinct cell fates, but also to organize these cells spatially within the developing organism. We discuss the central role of GSK3 in control of the Wnt, Hedgehog, cAMP (in Dictyostelium), and other signaling pathways, but also focus on significant new evidence that GSK3 is required to establish cell polarity.
Keywords: Wnt, Frizzled, Hedgehog, Presenilin, PAR, Cell Motility, Chemotaxis, Dictyostelium
Current Drug Targets
Title: GSK3 at the Edge: Regulation of Developmental Specification and Cell Polarization
Volume: 7 Issue: 11
Author(s): Leung Kim and Alan R. Kimmel
Affiliation:
Keywords: Wnt, Frizzled, Hedgehog, Presenilin, PAR, Cell Motility, Chemotaxis, Dictyostelium
Abstract: GSK3 is a multifunctional protein kinase that is pivotal for the regulation of metabolism, the cytoskeleton, and gene expression. Multicellular eukaryotes utilize GSK3 as a molecular switch to specify distinct cell fates, but also to organize these cells spatially within the developing organism. We discuss the central role of GSK3 in control of the Wnt, Hedgehog, cAMP (in Dictyostelium), and other signaling pathways, but also focus on significant new evidence that GSK3 is required to establish cell polarity.
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Cite this article as:
Kim Leung and Kimmel R. Alan, GSK3 at the Edge: Regulation of Developmental Specification and Cell Polarization, Current Drug Targets 2006; 7 (11) . https://dx.doi.org/10.2174/1389450110607011411
DOI https://dx.doi.org/10.2174/1389450110607011411 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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