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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Protein NMR-Based Screening in Drug Discovery

Author(s): E. R. Zartler and M. J. Shapiro

Volume 12, Issue 31, 2006

Page: [3963 - 3972] Pages: 10

DOI: 10.2174/138161206778743619

Price: $65

Abstract

Protein NMR as a screening tool in drug discovery has become prominent within the past ten years. Advances in protein manipulation, whether by biological means (labeling) or physical means (NMR), have created a powerful method that is able to observe ligand-target interactions in solution.

Keywords: NMR, Protein labeling, Chemical Shift Perturbtation, RAMPED-UP


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