Abstract
Protein NMR as a screening tool in drug discovery has become prominent within the past ten years. Advances in protein manipulation, whether by biological means (labeling) or physical means (NMR), have created a powerful method that is able to observe ligand-target interactions in solution.
Keywords: NMR, Protein labeling, Chemical Shift Perturbtation, RAMPED-UP
Current Pharmaceutical Design
Title: Protein NMR-Based Screening in Drug Discovery
Volume: 12 Issue: 31
Author(s): E. R. Zartler and M. J. Shapiro
Affiliation:
Keywords: NMR, Protein labeling, Chemical Shift Perturbtation, RAMPED-UP
Abstract: Protein NMR as a screening tool in drug discovery has become prominent within the past ten years. Advances in protein manipulation, whether by biological means (labeling) or physical means (NMR), have created a powerful method that is able to observe ligand-target interactions in solution.
Export Options
About this article
Cite this article as:
Zartler R. E. and Shapiro J. M., Protein NMR-Based Screening in Drug Discovery, Current Pharmaceutical Design 2006; 12 (31) . https://dx.doi.org/10.2174/138161206778743619
DOI https://dx.doi.org/10.2174/138161206778743619 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
Call for Papers in Thematic Issues
"Tuberculosis Prevention, Diagnosis and Drug Discovery"
The Nobel Prize-winning discoveries of Mycobacterium tuberculosis and streptomycin have enabled an appropriate diagnosis and an effective treatment of tuberculosis (TB). Since then, many newer diagnosis methods and drugs have been saving millions of lives. Despite advances in the past, TB is still a leading cause of infectious disease mortality ...read more
Current Pharmaceutical challenges in the treatment and diagnosis of neurological dysfunctions
Neurological dysfunctions (MND, ALS, MS, PD, AD, HD, ALS, Autism, OCD etc..) present significant challenges in both diagnosis and treatment, often necessitating innovative approaches and therapeutic interventions. This thematic issue aims to explore the current pharmaceutical landscape surrounding neurological disorders, shedding light on the challenges faced by researchers, clinicians, and ...read more
Emerging and re-emerging diseases
Faced with a possible endemic situation of COVID-19, the world has experienced two important phenomena, the emergence of new infectious diseases and/or the resurgence of previously eradicated infectious diseases. Furthermore, the geographic distribution of such diseases has also undergone changes. This context, in turn, may have a strong relationship with ...read more
Melanoma and Non-Melanoma Skin Cancer Treatment: Standard of Care and Recent Advances
In this thematic issue, we aim to provide a standard of care of the diagnosis and treatment of melanoma and non-melanoma skin cancer. The editor will invite authors from different countries who will write review articles of melanoma and non-melanoma skin cancers. The Diagnosis, Staging, Surgical Treatment, Non-Surgical Treatment all ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Anal Carcinoma
Current Cancer Therapy Reviews Protein Aggregation and Defective RNA Metabolism as Mechanisms for Motor Neuron Damage
CNS & Neurological Disorders - Drug Targets Mass Spectrometry Based Strategies in Quantitative Proteomics
Current Analytical Chemistry Silver Based Materials for Biomedical Applications
Current Organic Chemistry The Dark Side of Stem Cells: Triggering Cancer Progression by Cell Fusion
Current Molecular Medicine A Novel Synthesis Method of Apogossypolone and its Antitumor Activity
Letters in Drug Design & Discovery Functional Genomics and NMR Spectroscopy
Combinatorial Chemistry & High Throughput Screening Biomarker Discovery and Translation in Metabolomics
Current Metabolomics Clinical Evaluation of Anti-Obesity Drugs
Current Drug Targets Scaling Factors for the Extrapolation of In Vivo Metabolic Drug Clearance From In Vitro Data: Reaching a Consensus on Values of Human Micro-somal Protein and Hepatocellularity Per Gram of Liver
Current Drug Metabolism NMR-based Metabolite Profiling of Pancreatic Cancer
Current Metabolomics Formamide Derivatives of Resveratrol: Synthesis, Characterization and Cytotoxicity
Letters in Drug Design & Discovery Applications of Molecularly Imprinted Polymers for Isolation of Estrogens from Environmental Water Samples
Current Analytical Chemistry Opioid Transport by ATP-Binding Cassette Transporters at the Blood-Brain Barrier: Implications for Neuropsychopharmacology
Current Pharmaceutical Design Oral Administration of Thioflavin T Prevents Beta Amyloid Plaque Formation in Double Transgenic AD Mice
Current Alzheimer Research Triazole as Potent Anti-cancer Agent- A Pharmacophoric Scaffold
Current Cancer Therapy Reviews Synthesis of Glutamate-Zinc-Aluminium-Layered Double Hydroxide Nanobiocomposites and Cell Viability Study
Current Nanoscience Environmental Contaminants Perturb Fragile Protein Assemblies and Inhibit Normal Protein Function
Current Chemical Biology Advances in the Prediction of Protein Aggregation Propensity
Current Medicinal Chemistry Biochemical and Biological Quality Control of Two Recombinant Human Erythropoietin Biosimilar Products
Current Pharmaceutical Analysis