Abstract
Ageing and inflammation might be considered as natural partners. Numerous mechanisms of an inflammatory basis for several age-associated diseases have been identified. Some markers of inflammation are already being integrated into clinical medicine. Furthermore, existent anti-inflammatory drugs and novel candidates have been found to specifically target inflammation pathways in the ageing processes. In this review, we focus on the current knowledge on the field, from the molecular and cellular level to the therapeutic potential of anti-inflammatory agents. First, we present several theories of ageing, in order to explore the involvement of inflammation and to define targets of intervention. Then, we discuss the current approaches and applications as well as the future trends in research regarding the involvement of antiinflammatory agents in the ageing processes.
Keywords: Ageing, anti-inflammatory agents, inflammation
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Title: Anti-Inflammatory Agents in Ageing and Age-Associated Diseases
Volume: 5 Issue: 4
Author(s): S. Bonovas and N. M. Sitaras
Affiliation:
Keywords: Ageing, anti-inflammatory agents, inflammation
Abstract: Ageing and inflammation might be considered as natural partners. Numerous mechanisms of an inflammatory basis for several age-associated diseases have been identified. Some markers of inflammation are already being integrated into clinical medicine. Furthermore, existent anti-inflammatory drugs and novel candidates have been found to specifically target inflammation pathways in the ageing processes. In this review, we focus on the current knowledge on the field, from the molecular and cellular level to the therapeutic potential of anti-inflammatory agents. First, we present several theories of ageing, in order to explore the involvement of inflammation and to define targets of intervention. Then, we discuss the current approaches and applications as well as the future trends in research regarding the involvement of antiinflammatory agents in the ageing processes.
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Cite this article as:
Bonovas S. and Sitaras M. N., Anti-Inflammatory Agents in Ageing and Age-Associated Diseases, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 2006; 5 (4) . https://dx.doi.org/10.2174/187152306778772856
DOI https://dx.doi.org/10.2174/187152306778772856 |
Print ISSN 1871-5230 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-614X |
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