Abstract
Amphiphilic block copolymers often form core-shell type micelles by self-organization of the blocks in an aqueous medium or under specific experimental conditions. Polymeric micelles constructed from these polymers that contain a segment whose physical or chemical properties respond to small changes in environmental conditions are collectively called ‘stimuli-sensitive ’ micelles. This class of nano-scaled constructs has been investigated as a promising anticancer drug carrier because the micelles are able to utilize small environmental changes and modify drug release kinetics, biodistribution and the interactions with tissues and cells. This review summarizes the recent progress in stimuli-sensitive micelles for tumor chemotherapy, particularly for those responding to hyperthermic conditions, tumor pH and endosomal/ lysosomal pH.
Keywords: Micelles, self-organization, stimuli-sensitive, hyperthermic conditions, tumor pH, endosomal/lysosomal pH
Anti-Cancer Agents in Medicinal Chemistry
Title: Stimuli-Sensitive Polymeric Micelles as Anticancer Drug Carriers
Volume: 6 Issue: 6
Author(s): Kun Na, Vijay T. Sethuraman, You Han Bae and Vijay A. Sethuraman
Affiliation:
Keywords: Micelles, self-organization, stimuli-sensitive, hyperthermic conditions, tumor pH, endosomal/lysosomal pH
Abstract: Amphiphilic block copolymers often form core-shell type micelles by self-organization of the blocks in an aqueous medium or under specific experimental conditions. Polymeric micelles constructed from these polymers that contain a segment whose physical or chemical properties respond to small changes in environmental conditions are collectively called ‘stimuli-sensitive ’ micelles. This class of nano-scaled constructs has been investigated as a promising anticancer drug carrier because the micelles are able to utilize small environmental changes and modify drug release kinetics, biodistribution and the interactions with tissues and cells. This review summarizes the recent progress in stimuli-sensitive micelles for tumor chemotherapy, particularly for those responding to hyperthermic conditions, tumor pH and endosomal/ lysosomal pH.
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Cite this article as:
Na Kun, Sethuraman T. Vijay, Han Bae You and Sethuraman A. Vijay, Stimuli-Sensitive Polymeric Micelles as Anticancer Drug Carriers, Anti-Cancer Agents in Medicinal Chemistry 2006; 6 (6) . https://dx.doi.org/10.2174/187152006778699068
DOI https://dx.doi.org/10.2174/187152006778699068 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
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