Anti-Cancer Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

This journal supports open access

Editor-in-Chief:

Michelle Prudhomme
Institut de Chimie de Clermont-Ferrand
ICCF-CNRS UMR 6296
Université Clermont Auvergne
Clermont-Ferrand
France

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Articles Ahead of Print

Inhibition of Polo-Like Kinase 1 by BI2536 Reverses the Multidrug Resistance of Human Hepatoma Cells in vitro and in vivo

Volume:19
Hui Yu Li, Fei Luo, Xiao Yu Li, Xi Feng Fu, Jie Feng He, Yan Zhang Tian, Jun Jun Zhu, Xin Yi Chu and Hao Liang Zhao*

Two Novel tri-aryl Derivatives Attenuate the Invasion-Promoting Effects of Stromal Mesenchymal Stem Cells on Breast Cancer

Volume:19
Khadijeh Moradi, Farnaz Barneh, Saeed Irian, Mohsen Amini, Raheleh Moradpoor, Amir Amanzadeh, Samira Choopani, Hamzeh Rahimi, Tayebeh Ghodselahi, Massoud Mashhadi Akbaroujar and Mona Salimi*

Analysis of Comparative Proteomic and Potent Targets of Peniciketal A in Human Acute Monocytic Leukemia

Volume:19
Xue Gao , Yuming Zhou, Hongliu Sun, Desheng Liu , Jing Zhang , Junru Zhang, Weizhong Liu * and Xiaohong Pan*

Biological and Toxicological Evaluation of N-(4methyl-phenyl)-4-methylphthalimide on Bone Cancer in Mice

Volume:19
José Roberto Santin, Gislaine Francieli da Silva, Maria Veronica Davila Pastor, Milena Fronza Broering, Roberta Nunes, Rodolpho Campos Braga, Iury Tércio Simões de Sousa, Dorimar Serafim Stiz, Kathryn Ana Bortolini Simão da Silva, Luis Carlos Stoeberl, Rogério Corrêa, Valdir Cechinel Filho, Carlos Eduardo Matos dos Santos and Nara Lins Meira Quintão*

Synthesis and Biological Evaluation of Novel Heterocyclic Imines Linked Coumarin- Thiazole Hybrids as Anticancer Agents

Volume:19
Nerella Sridhar Goud, S. Mahammad Ghouse, Jatoth Vishnu, Jakkula Pranay, Ravi Alvala, Venu Talla, Insaf A. Qureshi and Mallika Alvala*

NF-κB-Induced Upregulation of miR-548as-3p Increases Invasion of NSCLC by Targeting PTEN

Volume:19
Sakir Akgun, Hakan Kucuksayan, Osman N. Ozes, Ozge Can, Arsenal S. Alikanoglu, Mustafa Yildiz and Hakan Akca*

Bis (Isothiocyanatomethyl) Benzene, A Plant Derived Anti-Neoplastic Compound: Purified from Moringa Oleifera Leaf Extract

Volume:19
Samrat Paul, Piyali Basak*, Namrata Maity, Chayan Guha and Nandan Kumar Jana

Anti-Diarrheal Drug Repositioning In Tumour Cell Cytotoxicity

Volume:19
Jihene Elloumi-Mseddi, Dhouha Msalbi, Raouia Fakhfakh and Sami Aifa*

Adenosine Analogues as Opposite Modulators of the Cisplatin Resistance of Ovarian Cancer Cells

Volume:19
Katarzyna Bednarska-Szczepaniak*, Damian Krzyżanowski, Magdalena Klink* and Marek Nowak

Novel Fluorine Boron Hybrid Complex as Potential Antiproliferative Drugs on Colorectal Cancer Cell Line

Volume:19
Yasin Tülüce*, Hawro Dlawar Ismael Masseh, İsmail Koyuncu, Ahmet Kiliç, Mustafa Durgun and Halil Özkol

Synthesis and Screening of Pro-apoptotic and Angio-inhibitory Activity of Novel Benzisoxazole Derivatives Both In vitro and In vivo

Volume:19
Sathish Byrappa, Kavitha Rachaiah, Sumana Y. Kotian, Yashaswini Balaraju, Samudyata C. Prabhuswamimath, K. M. Lokanatha Rai and Bharathi P. Salimath*

Single-chain Antibody Against Reg4 Suppresses Gastric Cancer Cell Growth and Enhances 5-FU-induced Cell Death in vitro

Volume:19
Xue-Qing Zhang , Lu-Ting Yu, Pei Du, Tian-Qi Yin, Zhi-Yuan Zhang, Ying Xu , Xiang Li, You-Jie Li , Min Wang* and Chen Luo *

Design, Synthesis and Evaluation of Novel 3/4-((Substituted benzamidophenoxy) methyl)-N-hydroxybenzamides/propenamides as Histone Deacetylase Inhibitors and Antitumor Agents

Volume:18
Duong Tien Anh, Nguyen Thi Thuan, Pham-The Hai, Le-Thi-Thu Huong, Nguyen Thi Kim Yen, Byung Woo Han, Eun Jae Park, Yeo Jin Choi, Jong Soon Kang, Van Thi My Hue*, Sang-Bae Han* and Nguyen-Hai Nam*

Synthesis and In Vitro Evaluation of Tetrahydroquinoline Derivatives as Antiproliferative Compounds of Breast Cancer via Targeting The GPER

Volume:18
Oscar Jovan Zacarías-Lara, David Méndez-Luna, Gustavo Martínez-Ruíz, José Ruben García-Sanchéz, Manuel Jonathan Fragoso-Vázquez*, Martiniano Bello, Elvia Becerra-Martínez, Juan Benjamín García-Vázquez* and José Correa-Basurto*

Integrins as A New Target for Cancer Treatment

Volume:18
Izabela Łasiñska* and Jacek Mackiewicz

Detection and Analysis of RNAs Expression Profile for Methylated Candidate Tumor Suppressor Genes in Nasopharyngeal Carcinoma

Volume:19
Shuang Zhao, Ye Zhang, Xujun Liang, Maoyu Li , Fang Peng, Zhuchu Chen and Yongheng Chen *

A New Synthetic Spiroketal: Studies on Antitumor Activity on Murine Melanoma Model In Vivo and Mechanism of Action In Vitro

Volume:19
Maria Pia Fuggetta*, Pietro Spanu*, Fausta Ulgheri, Francesco Deligia, Paola Carta, Alberto Mannu, Veronica Trotta, Rosanna De Cicco, Adriano Barra, Enrica Zona and Franco Morelli*

Synthesis of New N1Arylpiperazine Substituted Xanthine Derivatives and Evaluation of their Antioxidant and Cytotoxic Effects

Volume:19
Lily Andonova, Iva Valkova, Dimitrina Zheleva-Dimitrova, Maya Georgieva*, Georgi Momekov and Alexander Zlatkov

Synthesis of Dual Target CPT-Ala-Nor Conjugates and Their Biological Activity Evaluation

Volume:19
Chang K. Zhao*, Lang Xu, Xian H. Wang, Yu J. Bao and Yuhe Wang*

Nicotinamide Overcomes Doxorubicin Resistance of Breast Cancer Cells through Deregulating SIRT1/Akt Pathway

Volume:19
Yingze Wei, Yan Guo, Jianyun Zhou, Kui Dai, Qiang Xu and Xiaoxia Jin*

Hybridized Quinoline Derivatives as Anticancer Agents: Design, Synthesis, Biological Evaluation and Molecular Docking

Volume:18
Mohamed R. Selim, Medhat A. Zahran, Amany Belal*, Mostafa S. Mostafa*, Said A. Shedid, Ahmed B. M. Mehany, Gameel A. M. Elhagali and Yousry A. Ammar*

Let-7a Could Serve as A Biomarker for Chemo-Responsiveness to Docetaxel in Gastric Cancer

Volume:19
Najibeh Shekari, Faezeh Asghari, Navideh Haghnavaz, Dariush Shanehbandi, Vahid Khaze, Behzad Baradaran and Tohid Kazemi*

Hybrid Magnetic Nanostructures For Cancer Diagnosis And Therapy

Volume:18
Ardelean Lavinia Ioana, Denisa Ficai*, Maria Sonmez, Mihail Aurel Titu, Ovidiu Oprea, Gheorghe Nechifor, Anton Ficai and Ecaterina Andronescu

Induction of Apoptosis by Pierisin-6 in HPV Positive HeLa and HepG2 Cancer Cells is Mediated by the Caspase-3 Dependent Mitochondrial Pathway

Volume:19
Subbarayan Sarathbabu, Satheesh Kumar Marimuthu, Souvik Ghatak, Subramanian Vidyalakshmi, Guruswami Gurusubramanian , Sankar Kumar Ghosh, Selvi Subramanian, Wenqing Zhang and Nachimuthu Senthil Kumar*

Synthesis of Benzo[d]imidazo[2,1-b]thiazole-Propenone Conjugates as Cytotoxic and Apoptotic Inducing Agents

Volume:19
Siddiq Pasha Shaik, T. Srinivasa Reddy, Satish Sunkari, A. V. Subba Rao, Korrapati Suresh Babu, Suresh K. Bhargava and Ahmed Kamal*

Design, Synthesis and Antiproliferative Evaluation of Novel 1,2,4-Triazole/Schiff Base Hybrids with Egfr and B-Raf Inhibitory Activities

Volume:19
Hany A. M. El-Sherief, Bahaa G. M. Youssif*, Ahmed H. Abdelazeem, Mohamed Abdel-Aziz and Hamdy M. Abdel-Rahman*

Berberine Effects on NFκB, HIF1A and NFE2L2/AP-1 Pathways in HeLa Cells

Volume:19
Anna Belanova , Darya Beseda , Victor Chmykhalo , Alisa Stepanova , Mariya Belousova , Vera Khrenkova , Nikolaos Gavalas and Peter Zolotukhin*

Novel Inhibitors of DNA Repair Enzyme TDP1 Combining Monoterpenoid and Adamantane Fragments

Volume:19
Evgenii S. Mozhaitsev, Alexandra L. Zakharenko, Evgeniy V. Suslov*, Dina V. Korchagina, Olga D. Zakharova, Inna A. Vasil’eva, Arina A. Chepanova, Ellena Black, Jinal Patel, Raina Chand, Jóhannes Reynisson, Ivanhoe K. H. Leung, Konstantin P. Volcho, Nariman F. Salakhutdinov and Olga I. Lavrik

A Novel Camptothecin Derivative 3j Inhibits Nsclc Proliferation Via Induction of Cell Cycle Arrest By Topo I-Mediated DNA Damage

Volume:19
Yang Liu, Jingyin Zhang, Shuyun Feng, Tingli Zhao, Zhengzheng Li, Lai Wang, Puhai Wang, Hongzhi Du*, Shengtao Yuan* and Li Sun*

Isolation of a New Sesquiterpene Lactone From Vernonia Zeylanica (L) Less and its Anti-Proliferative Effects in Breast Cancer Cell Lines

Volume:19
Anuka S. Mendis*, M. Ira Thabrew, Meran K. Ediriweera, Sameera R. Samarakoon, Kamani H. Tennekoon, Achyut Adhikari* and E. Dilip de Silva

Virtual Screening of Natural Products to Select Compounds with Potential Anticancer Activity

Volume:19
Élida Batista Vieira Sousa Cavalcanti, Mayara Barbalho FÉlix, Luciana Scotti* and Marcus Tullius Scottia

3, 3′-Dimethylquercetin Inhibits the Proliferation of Human Colon Cancer RKO Cells through Inducing G2/M Cell Cycle Arrest and Apoptosis

Volume:19
Jianguo Wu, Jun Yi, Yanbin Wu, Xuzheng Chen, Jianwei Zeng, Jinzhong Wu* and Wei Peng*

Cyclosporine A Suppresses the Malignant Progression of Oral Squamous Cell Carcinoma in vitro

Volume:19
Ling Gao*, Jianwei Dong, Nanyang Zhang, Zhanxian Le, Wenhao Ren*, Shaoming Li, Fan Li, Jianzhong Song, Qibo Wang, Zhichao Dou, Soo Young Park and Keqian Zhi*

New Strategies for Therapeutic Cancer Vaccines

Volume:18
Hanjiao Qin, Jiyao Sheng, Dan Zhang, Xuewen Zhang, Linlin Liu*, Bingjin Li*, Guangquan Li* and Zhuo Zhang

Zinc Finger Nuclease Combines with Cisplatin and Trichostatin A Enhances the Antitumor Potency in Cervical Cancer Cells

Volume:18
Ci Ren, Chun Gao, Xiaomin Li, Hui Shen, Liming Wang, Da Zhu, Peng Wu, Ding Ma, Hui Wang* and Wencheng Ding*

Influence of Resveratrol on Sphingolipid Metabolism in Hepatocellular Carcinoma Cells in Lipid Overload State

Volume:19
Tomasz Charytoniuk*, Ewa Harasim-Symbor , Agnieszka Polak, Krzysztof Drygalski, Klaudia Berk, Adrian Chabowski and Karolina Konstantynowicz-Nowicka

Novel Benzo[B]Furans with Anti-Microtubule Activity Upregulate Expression of Apoptotic Genes and Arrest Leukemia Cells in G2/M Phase

Volume:19
Karolina Kró lewska-Goliñska, Marcin J. Cieślak*, Milena Sobczak, Rafał Dolot, Ewa Radzikowska-Cieciura, Mariola Napiórkowska, Iwona Wybrañska and Barbara Nawrot

Evaluation of Angiogenesis Process after Metformin and LY294002 Treatment in Mammary Tumor

Volume:19
Marina Gobbe Moschetta, Camila Leonel, Larissa Bazela Maschio-Signorini, Thaiz Ferraz Borin, Gabriela Bottaro Gelaleti, Bruna Victorasso Jardim-Perassi, Lívia Carvalho Ferreira, Nathália Martins Sonehara, Livia Gabriélle Silva Carvalho, Eva Hellmén and Debora Aparecida Pires de Campos Zuccari*

Cytotoxic Action of N-aryl, Furan-derived Aminophosphonates against HT29 and HCT116 Cancer Cell Lines

Volume:19
Jarosław Lewkowski*, Edyta Rzeszotarska, Agnieszka Matusiak, Marta Morawska, Gabriela Gajek, Karolina Nowak and Renata Kontek*

Determination of Usnic Acid Responsive miRNAs in Breast Cancer Cell Lines

Volume:18
Nil Kiliç, Yasemin Oztemur Islakoglu, İlker Buyuk, Bala Gur-Dedeoglu and Demet Cansaran-Duman*

Poly (ADP-Ribose) Polymerases (PARPs) and PARP Inhibitor-Targeted Therapeutics

Volume:18
Nan Li*, Yifan Wang, Weiye Deng and Steven Hsesheng Lin*

Selective Photodynamic Effects on Breast Cancer Cells Provided by P123 Pluronic®- Based Nanoparticles Modulating Hypericin Delivery

Volume:18
Gabrielle Marconi Zago Ferreira Damke, Raquel Pantarotto Souza, Maiara Camotti Montanha, Edilson Damke, Renato Sonchini Gonçalves, Gabriel Batista Cesar, Elza Kimura, Wilker Caetano, Noboru Hioka and Marcia Edilaine Lopes Consolaro*

Antitumor Potential of Berberine and Cinnamic Acid against Solid Ehrlich Carcinoma in Mice

Volume:18
Rafa S. Almeer, Ahmed M. Aref, Romisa A. Hussein, Mohamed S. Othman and Ahmed E. Abdel Moneim*

Peptide R18H from Brn-2 Transcription Factor POU Domain Displays Antitumor Activity In Vitro and In Vivo And Induces Apoptosis in B16F10-Nex2 Cells

Volume:18
Fernanda Fernandes Miranda da Cunha, Katia Cristina Ugolini Mugnol, Filipe Menegatti de Melo , Marta Verônica da Silva Queiroz Nascimento, Ricardo Alexandre de Azevedo, Raquel Tamires Soares Santos, Jéssica Aparecida Magalhães, Danilo Ciccone Miguel , Dayane Batista Tada, Renato Arruda Mortara, Luiz Rodolpho Travassos and Denise Costa Arruda*

Phytochemicals in Anticancer Drug Development

Volume:18
Rohit Dutt, Vandana Garg, Naveen Khatri and A. K. Madan*

[10]-Gingerol Affects Multiple Metastatic Processes and Induces Apoptosis in MDAMB- 231 Breast Tumor Cells

Volume:18
Angelina M. Fuzer, Ana Carolina B. M. Martin, Amanda B. Becceneri, James A. da Silva, Paulo C. Vieira and Marcia R. Cominetti*

Crocetin and Crocin from Saffron in Cancer Chemotherapy and Chemoprevention

Volume:19
Claudio Festuccia*, Alessandro Colapietro, Andrea Mancini and Annamaria D'alessandro

The Anticancer Role of Omega-3 Polyunsaturated Fatty Acids was Closely Associated with the Increase in Genomic DNA Hydroxymethylation

Volume:18
Qionglin Huang, Mingming Mo, Yu Zhong, Qingjin Yang, Junjie Zhang, Xiaoxia Ye, Lijian Zhang and Chun Cai*

Alkylphospholipids are Signal Transduction Modulators with Potential for Anticancer Therapy

Volume:18
Martin Berger*, Ferda Kaleagasıoglu, Maya Margaritova Zaharieva and Spiro M. Konstantinov

Modulation of Mitochondrial and Epigenetic Targets by Polyphenols-rich Extract from Araucaria angustifolia in Larynx Carcinoma

Volume:18
Catia Santos Branco*, Angela Duong, Alencar K Machado, Gustavo Scola, Ana C Andreazza and Mirian Salvador

Can Combined Therapy Benefit Immune Checkpoint Blockade Response in Hepatocellular Carcinoma?

Volume:18
Fan Zhongqi, Sun Xiaodong, Chen Yuguo and Lv Guoyue*

Computational Studies in Drug Design Against Cancer

Volume:18
Baishakhi De, Koushik Bhandari, Francisco J. B. Mendonça, Marcus Tullius Scotti and Luciana Scotti*

What Makes Species Productive of Anti-Cancer Drugs? Clues from Drugs’ Species Origin, Druglikeness, Target and Pathway

Volume:18
Xiaofeng Li, Xiaoxu Li, Yinghong Li, Chunyan Yu, Weiwei Xue, Jie Hu*, Bo Li, Panpan Wang and Feng Zhu*

Phage Display Technology and its Applications in Cancer Immunotherapy

Volume:18
Yicun Wang, Yang Lin and Jiayin Lv*

Biological Activity and Physicochemical Properties of Dipeptidyl Nitrile Derivatives Against Pancreatic Ductal Adenocarcinoma Cells

Volume:18
José Carlos Quilles, Murillo Dorileo Leite Bernardi, Pedro Henrique Jatai Batista, Samelyn da Costa Martins Silva, Camila de Melo Romero Rocha, Carlos Alberto Montanari and Andrei Leitão*

Hydroxyl Group Difference between Anthraquinone Derivatives Regulate Different Cell Death Pathways via Nucleo-Cytoplasmic Shuttling of p53

Volume:18
Mohd Kamil, Ejazul Haque, Snober S. Mir*, Safia Irfan, Adria Hasan, Saba Sheikh, Shamshad Alam, Kausar Mahmood Ansari and Aamir Nazir

Evaluation of A Novel GLP-1R Ligand for PET Imaging of Prostate Cancer

Volume:18
Yuanyuan Yue, Yuping Xu, Lirong Huang, Donghui Pan, Zhicheng Bai, Lizhen Wang, Runlin Yang, Junjie Yan, Huizhu Song*, Xiaotian Li and Min Yang

Spectroscopic and In Silico DNA Binding Studies on the Interaction of Some New N-Substituted Rhodanines with Calf-thymus DNA: In Vitro Anticancer Activities

Volume:18
Imran Ali*, Mohammad Nadeem Lone, Zeid A. Alothman, Ahmad Yacine Badjah and Abdullah G. Alanazi

Design, Synthesis, In vitro Cytotoxic Activity Evaluation, and Study of Apoptosis Inducing Effect of New Styrylimidazo[1,2-a]Pyridines as Potent Anti-Breast Cancer Agents

Volume:18
Faeze Khalili, Sara Akrami, Malihe Safavi, Maryam Mohammadi-Khanaposhtanid, Mina Saeedi, Sussan Kabudanian Ardestani, Bagher Larijani, Afsaneh Zonouzi*, Maliheh Barazandeh Tehrani* and Mohammad Mahdavi*

Virtual Screening of Anti-Cancer Compounds: Application of Monte Carlo Technique

Volume:18
Alla P. Toropova*, Andrey A. Toropov, Emilio Benfenati, Danuta Leszczynska and Jerzy Leszczynski

Synthesis and Investigation of the Role of Benzopyran Dihydropyrimidinone Hybrids in Cell Proliferation, Migration and Tumor Growth

Volume:18
Ashutosh K. Dash, Debasis Nayak, Nazar Hussain, Mubashir Javed Mintoo, Sumera Bano, Archana Katoch, Dilip Manikaro Mondhe, Anindya Goswami and Debaraj Mukherjee*

Design, Synthesis, and Preliminary Bioactivity Evaluation of 2,7-Substituted Carbazole Derivatives as Potent Autotaxin Inhibitors and Antitumor Agents

Volume:18
Wenming Wang, Fengmei Zhao, Yarui Zhao, Weiwei Pan, Pengcheng Cao, Lintao Wu , Zhijun Wang, Xuan Zhao, Yi Zhao* and Hongfei Wang*

Immunotherapy in Patients with Recurrent and Metastatic Squamous Cell Carcinoma of the Head and Neck

Volume:18
Izabela Lasinska*, Tomasz Kolenda, Anna Teresiak, Katarzyna M. Lamperska, Lukasz Galus and Jacek Mackiewicz

Insights into the Biological Evaluation of Pterocarpanquinones and Carbapterocarpans with Anti-tumor Activity against MDR Leukemias

Volume:18
Vivian M Rumjanek*, Raquel C Maia, Eduardo J Salustiano and Paulo R. R. Costa