Anti-Cancer Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

This journal supports open access

Editor-in-Chief:

Michelle Prudhomme
Institut de Chimie de Clermont-Ferrand
ICCF-CNRS UMR 6296
Université Clermont Auvergne
Clermont-Ferrand
France

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Ahead of Print Article(s)

Pre-clinical Validation of Mito-targeted Nano-engineered Flavonoids Isolated From Selaginella bryopteris (Sanjeevani) As A Novel Cancer Prevention Strategy

Volume:18
Arpit Bhargava, Neelam Pathak, Sriram Seshadri, Neha Bunkar, Subodh Kumar Jain, Dinesh Mishra Kumar, Nirmal Kumar Lohiya and Pradyumna Kumar Mishra*

Determination of the Apoptotic Effect and Molecular Docking of Benzamide Derivative XT5 in K562 Cells

Volume:18
Tulin Ozkan, Yalda Hekmatshoar*, Tugba Ertan-Bolelli, Andry Nur Hidayat, Meral Beksac, Esin Aki-Yalcin, Ismail Yalcin and Asuman Sunguroglu

Astragalin Attenuates UVB Radiation-induced Actinic Keratosis Formation

Volume:18
Jian Zhang*, Na Li, Kun Zhang, Ping Pan, Hui Zhang, Ning Li, Qiong Tian, Li Zhang, Wenli Liu, Tianyuan Gao, Xin Mu, Dengchao Feng, Wei Guo and Xiaona Ma

Emodin Enhances the Chemosensitivity of Endometrial Cancer by Inhibiting ROS-Mediated Cisplatin-resistance

Volume:18
Ning Ding, Hong Zhang, Shan Su, Yumei Ding, Xiaohui Yu, Yujie Tang, Qingfang Wang and Peishu Liu*

ROS-scavenging and Anti-tyrosinase Properties of Crocetin on B16F10 Murine Melanoma Cells

Volume:18
Seyed Hamed Hashemi-Shahri, Alireza Golshan, Seyed Ahmad Mohajeri, Javad Baharara, Elaheh Amini, Farzaneh Salek, Amirhossein Sahebkar* and Zahra Tayarani-Najaran

The Effect of Flubendazole on Adhesion and Migration in SW480 and SW620 Colon Cancer Cells

Volume:18
Veronika Hanusova*, Lenka Skalova, Vera Kralova and Petra Matouskovs

Inhibition of Intercellular Communication between Prostate Cancer Cells by a Specific Anti-STEAP-1 Single Chain Antibody

Volume:18
Seyed-Alireza Esmaeili, Foroogh Nejatollahi* and Amirhossein Sahebkar

A Newly Synthetized Ferrocenyl Derivative Selectively Induces Apoptosis in ALL Lymphocytes through Mitochondrial Estrogen Receptors

Volume:18
Marjan Aghvami, Jalal Pourahmad*, Afshin Zarghi, Peyman Eshghi, Mohammad Hadi Zarei, Shabnam Farzaneh and Fatemeh Sattari

Synthesis and Evaluation of a New Series of Arylidene Indanones as Potential Anticancer Agents

Volume:18
Ahmet Ozdemir*, Sevtem Gokbulut, Belgin Sever, Gulsen Akalın Ciftci and Mehlika Dilek Altıntop

Design, Synthesis and Anti-breast Cancer Activity of Some Novel Substituted Isoxazoles as Anti-breast Cancer Agent

Volume:18
Santosh N Mokale*, Nikhil S Sakle, Swati A Bhavale, Deepak K Lokwani and Vishakha Shelke

Combined Evaluation of Expression of CXCR4 and Nrf2 as Prognostic Factor for Patients with Gastric Carcinoma

Volume:17
Shuo Yu, Tao Wu, Jia Wang, Chuantao Cheng, Jing Wang, Liangzhang Sun, Chao Liu, Gang Cao and Tinghua Hu*

Trichinella spiralis and Tumors: Cause, Coincidence or Treatment?

Volume:17
Chengshui Liao*, Xiangchao Cheng, Mingyuan Liu, Xuelin Wang and Pascal Boireau

A Comparison of Fucoidan Conjugated to Paclitaxel and Curcumin for the Dual Delivery of Cancer Therapeutic Agents

Volume:17
Nam Hoang Phan , Thao Thanh Ly, Minh Nguyet Pham , Thinh Duc Luu , Toi Van Vo , Phuong Ha-Lien Tran* and Thao Truong-Dinh Tran

Ganoderma lucidum Polysaccharides as An Anti-cancer Agent

Volume:17
Didem Sohretoglu* and Shile Huang

Modulation of Cancer Metabolism by Phytochemicals - A Brief Overview

Volume:17
Danina M. Muntean, Sturza Adrian*, Ioana Pavel and Oana Duicu

The Clinical and Experimental Research on the Treatment of Endometriosis with Thiostrepton

Volume:18
Ping Jin*, Fei Xiao CHEN, Yang Zi Li, Qing Qing Zhang and Jian Zhang

Anticancer Activity of Resorcinarene-PAMAM-Dendrimer Conjugates of Flutamide

Volume:18
Luis D. Pedro-Hernandez, Elena Martinez Klimova*, Mark Eugenii Martínez-Klimov, Sandra Cortez-Maya, Ana Cristina Vargas-Medina, Teresa Ramirez-Apan, Simon Hernandez-Ortega and Marcos Martínez-Garcia

Design, Synthesis and Cytotoxicity Evaluation of New 3, 5-Disubstituted-2- Thioxoimidazolidinones

Volume:18
Khaled Abdellatif*, Mostafa M Elbadawi, Mohammed T Elsaady, Amer Ali Abd El-Hafeez, Takashi Fujimura, Seiji Kawamoto and Ahmed I Khodair

Natural Compounds in the Chemoprevention of Malignant Melanoma

Volume:17
Corina Danciu *, Codruta Soica, Diana Antal, Alexa Ersilia , Roxana Ghiulai , Ioana Pavel , Florina Ardelean, Roxana Babuta, Alexandra Popescu and Cristina Dehelean

Computational Study of the Binding Modes of Diverse DPN Analogues on Estrogen Receptors (ER) and the Biological Evaluation of a New Potential Antiestrogenic Ligand

Volume:18
Marlet Martinez-Archundia*, J B García-Vázquez, B Colin-Astudillo, M. Bello , B. Prestegui-Martel, A. Chavez, A. Dueñas-González, M. J. Fragoso-Vázquez, J. Mendieta-Wejebe, E. Abarca-Rojano, D. Ordaz-Rosado, R. García-Becerra, D. Castillo-Bautista and J. Correa Basurto

Selecting Patients with Small Renal Masses for Active Surveillance

Volume:17
Michael H Johnson, Mohamad E Allaf and Phillip M Pierorazio*

Halilectin-3, a Lectin from the Marine Sponge Haliclona caerulea, Induces Apoptosis and Autophagy in Human Breast Cancer MCF7 Cells Through Caspase-9 Pathway and LC3-II Protein Expression

Volume:17
Luiz Gonzaga do Nascimento-Neto, Maria Guadalupe Cabral, Romulo Farias Carneiro, Zelia Silva, Francisco Vassiliepe Sousa Arruda, Celso Shiniti Nagano, Alexandra R Fernandes, Alexandre Holanda Sampaio, Edson Holanda Teixeira* and Paula Alexandra Videira*

Antineoplastic Effects of NF-

Volume:17
Priscila Maria Manzini Ramos*, Julia Alejandra Pezuk, Angel Mauricio Castro-Gamero, Harley Francisco de Oliveira, Carlos Alberto Scrideli, Kazuo Umezawa and Luiz Gonzaga Tone

Recent Development of Sulfonyl or Sulfonamide Hybrids as Potential Anticancer Agents: A Key Review

Volume:17
K. P. Rakesh, Shi-Meng Wang, Jing Leng, L Ravindar, Abdullah M Asiri, Hadi M Marwani and Hua-Li Qin*

Volatile Inhibitors of Phosphatidylinositol-3-Kinase (PI3K) Pathway: Anti-Cancer Potential of Aroma Compounds of Plant Essential Oils

Volume:17
Manobjyoti Bordoloi*, Surovi Saikia, Bhaskor Kolita, Rajeev Sarmah, Sonali Roy and Bardwi Narzary

Translational Research in Cutaneous Melanoma: New Therapeutic Perspectives

Volume:18
Antonio Marra, Cristina Ferrone, Celeste Fusciello, Giosue Scognamiglio, Soldano Ferrone, Stefano Pepe, Francesco Perri and Francesco Sabbatino*

A Review of Electroporation-based Antitumor Skin Therapies and Investigation of Betulinic Acid-loaded Ointment

Volume:17
Monika Bakonyi*, Szilvia Berko, Gabor Eros, Gabor Varju, Cristina Dehelean, Maria Budai Szucs and Erzsebet Csanyi

Synthesis of Biotinylated 2-methoxystrypandrone and Identification of JAK2 and IKK as its Targets

Volume:17
Shan Kuang, Zhenhua Sima, Jiawei Liu, Wuguo Li, Qiaoling Song, Qing Zhang and Qiang Yu*

The Impact of Translational Research in Breast Cancer Care: Can we Improve the Therapeutic Scenario?

Volume:17
Francesco Perri, Giuseppe Buono, Francesco Schettini, Grazia Arpino, Roberto Bianco, Carmen Criscitiello, Sabino De Placido and Mario Giuliano*

A Review of the Components of Seaweeds as Potential Candidates in Cancer Therapy

Volume:17
Ban-Feng Ruan, Wei-Wei Ge, Meng-Xue Lin and Qing-Shan Li*

4-aryl/heteroaryl-4H-fused Pyrans as Anti-proliferative Agents: Design, Synthesis and Biological Evaluation

Volume:17
Dinesh Kumar*, Gurpreet Singh, Pooja Sharma, Arem Qayum, Girish Mahajan, M. J. Mintoo, Shashank Kumar Singh, Dilip Manikrao Mondhe, PMS Bedi, Subheet K Jain and Girish Kumar Gupta

The Rationale for Repurposing Sildenafil for Lung Cancer Treatment

Volume:17
Theodore Keats, Rhonda J Rosengren and John C Ashton*

A Review on Melatonin’s Effects in Cancer: Potential Mechanisms

Volume:17
Tomris Ozben*, Aysegul Hanikoglu, Ertan Kucuksayan and Rana Cagla Akduman

CCL2 is Modulated by Cytokines and PPAR-g in Anaplastic Thyroid Cancer

Volume:17
Silvia Martina Ferrari, Giusy Elia, Simona Piaggi, Enke Baldini, Salvatore Ulisse, Mario Miccoli, Gabriele Materazzi, Alessandro Antonelli* and Poupak Fallahi

Dual Antibacterial and Anticancer Activity of 4-Benzoyl-1-dichlorobenzoylthiosemicarbazide Derivatives

Volume:17
Barbara Kapron, Robert Czarnomysy, Agata Paneth, Monika Wujec, Krzysztof Bielawski, Anna Bielawska, Lukasz Swiatek, Barbara Rajtar, Malgorzata Polz-Dacewicz and Tomasz Plech*

Antitumor Potential of Marine Natural Products: A Mechanistic Investigation

Volume:17
Liping Hu, Jie Ying, Miaomiao Zhang, Xiaoyan Qiu and Yu Lu*

Comparison of Physicochemical Properties of Generic Doxorubicin HCl Liposome Injection with the Reference Listed Drug

Volume:17
Subhas Bhowmick , Kuntal Maiti *, Pankaj Jain, Murlidhar Zope, Keyur Doshi and Thennati Rajamannar

New Ferrocene Compounds as Selective Cyclooxygenase (COX-2) Inhibitors: Design, Synthesis, Cytotoxicity and Enzyme-inhibitory Activity

Volume:17
Shabnam Farzaneh, Elnaz Zainalzadeh, Bahram Daraei, Soraya Shahhosseini and Afshin Zarghi*

Anticancer Properties of a New Hybrid Analog AD-013 Combining a Coumarin Scaffold with an α-methylene-δ-lactone Motif

Volume:17
Angelika Długosz, Katarzyna Gach-Janczak, Jacek Szymański, Dariusz Deredas, Henryk Krawczyk, Tomasz Janecki and Anna Janecka*

Antileukemic Properties of Sesquiterpene Lactones: A Systematic Review

Volume:17
Elaine da Silva Castro, Lívia Azeredo Alves Antunes, Jonathas Felipe Revoredo Lobo, Norman Arthur Ratcliffe, Ricardo Moreira Borges, Leandro Rocha, Patrícia Federal Burth and Lidia Maria Fonte Amorim*

Genistein Induces Alterations of Epigenetic Modulatory Signatures in Human Cervical Cancer Cells

Volume:17
Madhumitha Kedhari Sundaram, Mohammad Zeeshan Ansari, Abdullah Al Mutery, Maryam Ashraf, Reem Nasab, Sheethal Rai, Naushad Rais and Arif Hussain*

The Application of the Cold Atmospheric Plasma-Activated Solutions in Cancer Treatment

Volume:17
Dayun Yan, Jonathan H Sherman and Michael Keidar*

Human Fibronectin Extra-Domain B (EDB)-Specific Aptide (APTEDB) Radiolabelling with Technetium-99m as a Potent Targeted Tumour-Imaging Agent

Volume:17
Mohsen Mohammadgholi, Nourollah Sadeghzadeh*, Mostafa Erfani, Saeid Abediankenari, Seyed Mohammad Abedi, Iman Emrarian, Narjes Jafari and Ramezan Behzadi

Stereocomplexation Assisted Assembly of Poly(γ-glutamic Acid)-graft-polylactide Nano-micelles and Their Efficacy as Anticancer Drug Carrier

Volume:17
Shulin Dai, Yucheng Feng, Shuyi Li, Yuxiao Chen, Meiqing Liu, Chao Zhang*, Wei Zhang and Yihua Yin

Novel Findings of Anti-cancer Property of Propofol

Volume:17
Jiaqiang Wang, Chien-shan Cheng, Yan Lu, Xiaowei Ding, Minmin Zhu, Changhong Miao and Jiawei Chen*

Spices with Breast Cancer Chemopreventive and Therapeutic Potentials: A Functional Foods Based-Review

Volume:17
Aliyu Muhammad*, Mohammed Auwal Ibrahim, Ochuko Lucky Erukainure, Ibrahim Malami and Auwal Adamu

VDAC1 Mediated Anticancer Activity of Gallic Acid in Human Lung Adenocarcinoma A549 Cells

Volume:17
Aikebaier Maimaiti, Amier Aili, Hureshitanmu Kuerban and Xuejun Li*

Inhibition of Proliferation and Induction of Apoptosis by Thymoquinone via Modulation of TGF Family, p53, p21 and Bcl-2α in Leukemic Cells

Volume:17
Mona Diab Assaf, Josiane Semaan, Marwan El-Sabban, Soad K. Al-Jaouni, Rania Azar, Mohammad Amjad Kamal* and Steve Harakeh

The Measurement and Mathematical Analysis of 5-Fu Release from Magnetic Polymeric Nanocapsules, following the Application of Ultrasound

Volume:17
Ziaeddin Abed, Samideh Khoei, Behafarid Ghalandari, Jaber Beik, Ali Shakeri-Zadeh, Habib Ghaznavi* and Mohammad Bagher Shiran

Effects of Plasma Activated Medium on Head and Neck FaDu Cancerous Cells: Comparison of 3D and 2D Response

Volume:17
Merbahi Nofel*, Julie Chauvin, Patricia Vicendo and Florian Judée

Effects of Ascorbic Acid on Tax, NF-κB and MMP-9 in Human T-cell Lymphotropic Virus Type 1 Positive Malignant T-Lymphocytes

Volume:17
Steve Harakeh*, Jihane Khalife, Elias Baydoun, Rania Azar, Ahmed Al- Hejin, Elie Barbour, Esam Azhar, Aleksandra Niedzwiecki, Soad Al Jaouni, Mona Diab-Assaf, Mohammad Amjad Kamal and Mathias Rath

Design and Discovery of Novel Quinoxaline Derivatives as Dual DNA Intercalators and Topoisomerase II Inhibitors

Volume:17
Ibrahim H. Eissa, Abeer M. El-Naggar*, Nour E.A. Abd El-Sattar and Ahmed S. A Youssef

Pyramidatine (Z88) Sensitizes Vincristine-Resistant Human Oral Cancer (KB/VCR) Cells to Chemotherapeutic Agents by Inhibition of P-glycoprotein

Volume:17
Zulong Liu, Hengrui Zhu, Shijin Qu, Lisha Tang, Lihuan Cao, Wenbo Yu, Xianmei Yang, Songmin Jiang, Dayuan Zhu, Changheng Tan and Long Yu*

Hydrogen Peroxide and Beyond-the Potential of High-voltage Plasma-activated Liquids Against Cancerous Cells

Volume:17
Daniela Boehm, James Curtin, Patrick J. Cullen and Paula Bourke*

Effect of Number of Bifunctional Chelating Agents on the Pharmacokinetics and Immunoreactivity of 177Lu-labeled Rituximab: A Systemic Study

Volume:17
Mohini Guleria, Tapas Das*, Chandan Kumar, Rohit Sharma, Jeyachitra Amirdhanayagam, Haladhar D. Sarma and Ashutosh Dash

Novel Fluorinated Porphyrins Sensitize Tumor Cells to Photodamage in Normoxia and Hypoxia: Synthesis and Biocompatible Formulations

Volume:17
Elizaveta . V. Belyaeva, Alina A. Markova, Dmitry N. Kaluzhnyb, Andrei L. Sigan, Lev L. Gervitz, Aida N. Ataeva, Nikolai D. Chkanikov and Alexander A. Shtil*

From Biology to Therapy: Improvements of Therapeutic Options in Lung Cancer

Volume:17
Luigi Formisano, Valerie M. Jansen, Roberta Marciano and Roberto Bianco*

Structure-Based Design: Synthesis, X-ray Crystallography, and Biological Evaluation of N-Substituted-4-Hydroxy-2-Quinolone-3-Carboxamides as Potential Cytotoxic Agents

Volume:17
Dima A. Sabbah*, Bayan Hishmah, Kamal Sweidan, Sanaa Bardaweel,, Murad AlDamen, Haizhen A. Zhong, Reema Abu Khalaf, Ameerah Hasan Ibrahim, Tariq Al-Qirim, Ghassan Abu Sheikha and Mohammad S. Mubarak

Tumor-Targeting Peptides: Ligands for Molecular Imaging and Therapy

Volume:17
Ning Zhao, Yeshan Qin, Hongguang Liu and Z. Cheng*

Rationale Design, Synthesis, Cytotoxicity Evaluation, and Molecular Docking Studies of 1,3,4-oxadiazole Analogues

Volume:17
Mohamed Jawed Ahsan*, Arun Choupra, Rakesh Kumar Sharma, Surender Singh Jadav, Mohd. Zaheen Hassan, Mohammed Afroz Bakht, Pannala Padmaja, Abdulmalik Bin Saleh Al-Tamimi and Mohammed H. Geesi

Discovery of Novel 2-Amino-5-(Substituted)-1,3,4-Thiadiazole Derivatives: New Utilities for Colon Cancer Treatment

Volume:17
Vinit Raj, Amit Rai, Ashok K Singh, Amit K Keshari, Prakruti Harshvardhanbhai Trivedi, Balaram Ghosh, Umesh Kumar, Dinesh Kumar and Sudipta Saha*

Synthesis, Characterization, and Inducing Tumor Cell Apoptosis of Two Ru(II) Complexes Containing Guanidinium as Ligands

Volume:17
Jing Sun*, Wen-Xiu Chen, Xing-Dong Song, Shu-Fen He, Jia-Xi Chen, Jun Mei, Xiao-Xian Zhu and Tie Wu

The Emerging Roles of RASSF5 in Human Malignancy

Volume:17
Shuofeng Li, Jingwei Teng, Haiqing Li, Junnian Zheng and Feifei Chen*

A Comparison of the Toxicity of Mono, Bis, Tris and Tetrakis Phosphino Silver Complexes on SNO Esophageal Cancer Cells

Volume:17
Zelinda Engelbrecht, Kariska Potgieter, Zenele Mpela, Rehana Malgas-Enus, Reinout Meijboom and Marianne J Cronje*

Increased Expression of IRE1α Associates with the Resistant Mechanism of Osimertinib (AZD9291)-resistant non-small Cell Lung Cancer HCC827/OSIR Cells

Volume:17
Zheng-hai Tang*, Min-Xia Su, Xia Guo, Xiao-Ming Jiang, Lin Jia, Xiuping Chen and Jin-Jian Lu

Synthesis and Evaluation of 2-Naphthaleno trans-Stilbenes and Cyanostilbenes as Anticancer Agents

Volume:17
Nikhil R. Madadi, Narsimha R. Penthala, Amit Ketkar, Robert L. Eoff, Vicenta Trujullo-Alonso, Monica L. Guzman and Peter A. Crooks*