Anti-Cancer Agents in Medicinal Chemistry

Inhibition of TGF-β Signaling in Tumor Cells by Small Molecule Src Family Kinase Inhibitors

Volume: 17   Issue: 10
Pp: 1351-1356
Tobias Bartscht, Benjamin Rosien, Dirk Rades, Roland Kaufmann, Harald Biersack, Hendrik Lehnerta and Hendrik Ungefroren
DOI: 10.2174/1871520617666170103094946

Novel Thiourea Derivatives Bearing Sulfonamide Moiety as Anticancer Agents Through COX-2 Inhibition

Volume: 17   Issue: 10
Pp: 1411-1425
Mostafa M. Ghorab, Mohamed S.A. El-Gaby, Mansour S. Alsaid, Yaseen A.M.M. Elshaier, Aiten M. Soliman , Fardous F. El-Senduny , Farid A. Badria and Abdelrahman Y.A. Sherif
DOI: 10.2174/1871520617666170327153735

Cytokine Status of Serum in Ovarian Cancer Patients with Different Tumor Neoadjuvant Chemotherapy Response

Volume: 17   Issue: 9
Pp: 1251-1255
Inna I. Antoneeva, Tatyana V. Abakumova, Dinara R. Dolgova, Tatyana P. Gening, Sabina S. Pirmamedova, Dinara F. Myasnikova and Snezhanna O. Gening
DOI: 10.2174/1871520617666170103100350

Ring A-modified Derivatives from the Natural Triterpene 3-O-acetyl-11-keto-β-Boswellic Acid and their Cytotoxic Activity

Volume: 17   Issue: 8
Pp: 1153-1167
Tao Li, Peihong Fan, Yaqing Ye, Qian Luo and Hongxiang Lou
DOI: 10.2174/1871520616666161207144031

Polo-like Kinase 1-targeting Chitosan Nanoparticles Suppress the Progression of Hepatocellular Carcinoma

Volume: 17   Issue: 7
Pp: 948-954
Dongzhi Wang, Renan Chang, Gang Wang, Baoying Hu, Yong Qiang and Zhong Chen
DOI: 10.2174/1871520616666160926111911

2-(ω-Carboxyethyl)pyrrole Antibody as a New Inhibitor of Tumor Angiogenesis and Growth

Volume: 17   Issue: 6
Pp: 813-820
Chunying Wu, Xizhen Wang, Nicholas Tomko, Junqing Zhu, William R. Wang, Jinle Zhu, Bin Wangf, Yanming Wang and Robert G. Salomon
DOI: 10.2174/1871520616666160923093959

Differential Cytotoxicity, Cellular Uptake, Apoptosis and Inhibition of BRCA1 Expression of BRCA1-Defective and Sporadic Breast Cancer Cells Induced by an Anticancer Ruthenium(II)-Arene Compound, RAPTA-EA1

Volume: 17   Issue: 2
Pp: 212-220
Adisorn Ratanaphan, Tidarat Nhukeaw, Khwanjira Hongthong and Paul J. Dyson
DOI: 10.2174/1871520616666160404110953

Design, Synthesis and Evaluation of 5-pyridin-4-yl-2-thioxo-[1,3,4]oxadiazol-3-yl Derivatives as Anti-angiogenic Agents Targeting VEGFR-2

Volume: 17   Issue: 1
Pp: 67-74
Umesh Bhanushali, Samidha Kalekar-Joshi, Renuka Kulkarni-Munshi, Swapna Yellanki, Raghavender Medishetty, Pushkar Kulkarni and Ramaa Subramanian Chelakara
DOI: 10.2174/1871520615666160504094222

Brain-metastatic Breast Cancer: Clinical Considerations and Pharmacological Approaches

Volume: 16   Issue: 12
Pp: 1523-1528
Ana C. Andrade, Daniel S. Ferruzzi and Carolina Panis
DOI: 10.2174/1871520616666160404112508

Molecular Mechanisms of Anti-cancer Activities of β-elemene: Targeting Hallmarks of Cancer

Volume: 16   Issue: 11
Pp: 1426-1434
Shiyu Jiang, Chunhua Ling, Wei Li, Hongxin Jiang, Qiaoming Zhi and Min Jiang
DOI: 10.2174/1871520616666160211123424

Flavonoids with Therapeutic Potential in Prostate Cancer

Volume: 16   Issue: 10
Pp: 1205-1229
Bao Vue, Sheng Zhang and Qiao-Hong Chen
DOI: 10.2174/1871520615666151008122622

Synthesis of Combretastatin A-4 Analogs and their Biological Activities

Volume: 16   Issue: 8
Pp: 942-960
Agnieszka Siebert, Monika Gensicka, Grzegorz Cholewinski and Krystyna Dzierzbicka
DOI: 10.2174/1871520616666160204111832

α(N)-Heterocyclic Thiosemicarbazones: Iron Chelators that are Promising for Revival of Gallium in Cancer Chemotherapy

Volume: 16   Issue: 8
Pp: 973-991
Shuhong Cao, Xiahui Chen, Ligen Chen and Jingwen Chen
DOI: 10.2174/1871520616666160310142012

A Review on Novel Breast Cancer Therapies: Photodynamic Therapy and Plant Derived Agent Induced Cell Death Mechanisms

Volume: 16   Issue: 7
Pp: 793-801
Blassan Plackal Adimuriyil George and Heidi Abrahamse
DOI: 10.2174/1871520615666151026094028

Blood-Brain Barrier and Breast Cancer Resistance Protein: A Limit to the Therapy of CNS Tumors and Neurodegenerative Diseases open access plus

Volume: 16   Issue: 7
Pp: 810-815
Anna Lisa Iorio, Martina da Ros, Ornella Fantappiè, Maurizio Lucchesi, Ludovica Facchini, Alessia Stival, Sabrina Becciani, Milena Guidi, Claudio Favre, Maurizio de Martino, Lorenzo Genitori and Iacopo Sardi
DOI: 10.2174/1871520616666151120121928

Paclitaxel Loaded Nanoliposomes in Thermosensitive Hydrogel: A Dual Approach for Sustained and Localized Delivery

Volume: 16   Issue: 3
Pp: 365-376
Mohit Mahajan, Puneet Utreja and Subheet Kumar Jain
DOI: 10.2174/1871520615666150807103910

CXCR4 and Glioblastoma promotion: free to download

Volume: 16   Issue: 1
Pp: 59-74
Peter J. Richardson
DOI: 10.2174/1871520615666150824153032

Role of Rap2 and its Downstream Effectors in Tumorigenesis

Volume: 15   Issue: 10
Pp: 1269-1276
Hui Huang, Jiehui Di, Debao Qu, Zhen Gao, Yanping Zhang and Junnian Zheng
DOI: 10.2174/1871520615666150518092840

Recent Advances in Phenanthroindolizidine and Phenanthroquinolizidine Derivatives with Anticancer Activities

Volume: 15   Issue: 9
Pp: 1080-1091
Maria de Fatima Pereira, Christophe Rochais and Patrick Dallemagne
DOI: 10.2174/1871520615666150520143600

Anticancer Agents Derived from Natural Cinnamic Acids

Volume: 15   Issue: 8
Pp: 980-987
Ping Su, Yaling Shi, Jinfeng Wang, Xiuxiu Shen and Jie Zhang
DOI: 10.2174/1871520615666150130111120

Is Notch Signaling a Specific Target in Hepatocellular Carcinoma?

Volume: 15   Issue: 7
Pp: 809-815
Lichun Sun, Guangchun Sun, Yan Yu and David H. Coy
DOI: 10.2174/1871520615666150202102809

Molecular Mechanism Behind the Synergistic Activity of Diphenylmethyl Selenocyanate and Cisplatin Against Murine Tumor Model

Volume: 15   Issue: 4
Pp: 501-510
Pramita Chakraborty, Somnath Singha Roy and Sudin Bhattacharya
DOI: 10.2174/1871520615666150113123401

Immune Checkpoint Inhibitors for Non-small-cell Lung Cancer: Does that Represent a ‘New Frontier’?

Volume: 15   Issue: 3
Pp: 307-313
Sara Pilotto, Stefania Kinspergher, Umberto Peretti, Anna Calio, Luisa Carbognin, Roberto Ferrara, Matteo Brunelli, Marco Chilosi, Giampaolo Tortora and Emilio Bria
DOI: 10.2174/1871520614666141110170259

Recent Developments on Thiourea Based Anticancer Chemotherapeutics

Volume: 15   Issue: 2
Pp: 163-175
Vikas Kumar and Swapandeep Singh Chimni
DOI: 10.2174/1871520614666140407123526

Berberine Interfered with Breast Cancer Cells Metabolism, Balancing Energy Homeostasis promotion: free to download

Volume: 15   Issue: 1
Pp: 66-78
Wen Tan, Ning Li, Rui Tan, Zhangfeng Zhong, Zhanwei Suo, Xian Yang, Yitao Wang and Xiaodong Hu
DOI: 10.2174/1871520614666140910120518

Pro-Oxidative Action of Polyphenols as Action Mechanism for their Pro-Apoptotic Activity

Volume: 14   Issue: 10
Pp: 1363-1375
Raffaella Marina Lecci, Antonio Logrieco and Antonella Leone
DOI: 10.2174/1871520614666140922121014

New Potent and Selective Inhibitor of Pim-1/3 Protein Kinases Sensitizes Human Colon Carcinoma Cells to Doxorubicin

Volume: 14   Issue: 9
Pp: 1228-1236
Pascale Moreau, Lyubov G. Dezhenkova, Fabrice Anizon, Lionel Nauton, Vincent Thery, Shuguang Liang, Dmitry N. Kaluzhny and Alexander A. Shtil
DOI: 10.2174/1871520614666140825124456