Abstract
The structural and functional aspects of cytochrome P450 (CYP) enzymes are reviewed in the light of current developments in X-ray crystallography and other physical evidence, together with recent findings on the regulation of, and polymorphisms in, the human drug-metabolizing CYPs. It is emphasized that the crystal structures of eukaryotic CYPs are particuarly useful for constructing homology models of the human enzymes associated with drug metabolism, and that these models can aid in the high-throughput screening of novel compounds destined for human exposure.
Keywords: Cytochromes P450 (CYPs), drug metabolism, enzyme structure and function
Current Medicinal Chemistry
Title: Structural Modelling of the Human Drug-Metabolizing Cytochromes P450
Volume: 13 Issue: 22
Author(s): David F.V. Lewis, Yuko Ito and Peter S. Goldfarb
Affiliation:
Keywords: Cytochromes P450 (CYPs), drug metabolism, enzyme structure and function
Abstract: The structural and functional aspects of cytochrome P450 (CYP) enzymes are reviewed in the light of current developments in X-ray crystallography and other physical evidence, together with recent findings on the regulation of, and polymorphisms in, the human drug-metabolizing CYPs. It is emphasized that the crystal structures of eukaryotic CYPs are particuarly useful for constructing homology models of the human enzymes associated with drug metabolism, and that these models can aid in the high-throughput screening of novel compounds destined for human exposure.
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Cite this article as:
Lewis F.V. David, Ito Yuko and Goldfarb S. Peter, Structural Modelling of the Human Drug-Metabolizing Cytochromes P450, Current Medicinal Chemistry 2006; 13 (22) . https://dx.doi.org/10.2174/092986706778201567
DOI https://dx.doi.org/10.2174/092986706778201567 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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