Abstract
At the present time, 160 human glycogenes encoding glycosyltransferases and sulfotransferases, which add sulfate to carbohydrates, have been cloned and analyzed for their substrate specificity. Mice have almost all genes orthologous to them, and some are specifically expressed in neuronal tissues. In this review, neurological disorders of mice deficient for the glycogenes that synthesize interesting carbohydrate epitopes in neuronal tissues are described and summarized.
Keywords: Glycogene, glycosyltransferase, sulfotransferase, ganglioside, HNK-1, Lewis X, polysialic acid, knockout mouse
CNS & Neurological Disorders - Drug Targets
Title: Neurological Disorders in Mice Lacking Glycogenes that are Mainly Expressed in Brain
Volume: 5 Issue: 4
Author(s): Hisashi Narimatsu
Affiliation:
Keywords: Glycogene, glycosyltransferase, sulfotransferase, ganglioside, HNK-1, Lewis X, polysialic acid, knockout mouse
Abstract: At the present time, 160 human glycogenes encoding glycosyltransferases and sulfotransferases, which add sulfate to carbohydrates, have been cloned and analyzed for their substrate specificity. Mice have almost all genes orthologous to them, and some are specifically expressed in neuronal tissues. In this review, neurological disorders of mice deficient for the glycogenes that synthesize interesting carbohydrate epitopes in neuronal tissues are described and summarized.
Export Options
About this article
Cite this article as:
Narimatsu Hisashi, Neurological Disorders in Mice Lacking Glycogenes that are Mainly Expressed in Brain, CNS & Neurological Disorders - Drug Targets 2006; 5 (4) . https://dx.doi.org/10.2174/187152706777950747
DOI https://dx.doi.org/10.2174/187152706777950747 |
Print ISSN 1871-5273 |
Publisher Name Bentham Science Publisher |
Online ISSN 1996-3181 |
Call for Papers in Thematic Issues
Diagnosis and treatment of central nervous system infectious diseases
Infectious diseases of the central nervous system (CNS) can be divided into bacterial, tuberculous, viral, fungal, parasitic infections, etc. Early etiological treatment is often the most crucial means to reduce the mortality rate of patients with central nervous system infections, reduce complications and sequelae, and improve prognosis. The initial clinical ...read more
Techniques of Drug Repurposing: Delivering a new life to Herbs & Drugs
Of late, with the adaptation of innovative approaches and integration of advancements made towards medical sciences as well as the availability of a wide range of tools; several therapeutic challenges are being translated into viable clinical solutions, with a high degree of efficacy, safety, and selectivity. With a better understanding ...read more
Trends and perspectives in the rational management of CNS disorders
Central nervous system (CNS) diseases enforce a significant global health burden, driving ongoing efforts to improve our understanding and effectiveness of therapy. This issue investigates current advances in the discipline, focusing on the understanding as well as therapeutic handling of various CNS diseases. The issue covers a variety of diseases, ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
PET Tracers for Serotonin Receptors and Their Applications
Central Nervous System Agents in Medicinal Chemistry Advances in Neuroimaging for HIV-1 Associated Neurological Dysfunction: Clues to the Diagnosis, Pathogenesis and Therapeutic Monitoring
Current HIV Research Brain Endothelial Cell-Cell Junctions: How to “Open” the Blood Brain Barrier
Current Neuropharmacology Colloidal Polymeric Nanoparticles and Brain Drug Delivery
Current Drug Delivery Animal Mitochondria: Evolution, Function, and Disease
Current Molecular Medicine Global Cerebral Ischemia: Synaptic and Cognitive Dysfunction
Current Drug Targets Truly “Rational” Polytherapy: Maximizing Efficacy and Minimizing Drug Interactions, Drug Load, and Adverse Effects
Current Neuropharmacology Commentary (Research Highlights: Transcranial Drug Delivery for Neurological Disorders)
CNS & Neurological Disorders - Drug Targets Bridging Over the Troubled Heterogeneity of SPG-Related Pathologies: Mechanisms Unite What Genetics Divide
Current Molecular Medicine Protective Effects of Melatonin and Mitochondria-targeted Antioxidants Against Oxidative Stress: A Review
Current Medicinal Chemistry Investigating Mitochondrial Dysfunction to Increase Drug Safety in the Pharmaceutical Industry
Current Drug Targets Conotoxins: Structure, Therapeutic Potential and Pharmacological Applications
Current Pharmaceutical Design Clinical Strategies for the Blockade of IL-18 in Inflammatory Bowel Diseases
Current Drug Targets Tackling the Elusive Challenges Relevant to Conquering the 100-Plus Year Old Problem of Alzheimer’s Disease
Current Alzheimer Research Models in Research of Pharmacoresistant Epilepsy: Present and Future in Development of Antiepileptic Drugs
Current Medicinal Chemistry Synthesis and Anticonvulsant Activity of Some Novel Semicarbazone Containing Benzoxazole: Pharmacophore Model Study
Current Bioactive Compounds Anticonvulsant Effect of the Essential Oil and Methanolic Extracts of <i>Zataria multiflora</i> Boiss
Central Nervous System Agents in Medicinal Chemistry Pycnogenol Protects against Pentylenetetrazole-Induced Oxidative Stress and Seizures in Mice
Current Clinical Pharmacology Emerging Pharmacological Properties of Cholinergic Synaptic Transmission: Comparison between Mammalian and Insect Synaptic and Extrasynaptic Nicotinic Receptors
Current Neuropharmacology Triheptanoin Supplementation to Ketogenic Diet Curbs Cognitive Impairment in APP/PS1 Mice Used as a Model of Familial Alzheimer’s Disease
Current Alzheimer Research