Abstract
Evidence implicating neural circuits that utilize the neuropeptide transmitter neurotensin (NT) in the pathophysiology of schizophrenia and in the mechanism of action of antipsychotic drugs has previously been reviewed. The majority of evidence, taken together, supports the development of NT receptor agonists as novel antipsychotic drugs. This review comprehensively describes the NT receptor subtypes, discusses the development of NT receptor agonists and the behavioral effects of currently available NT receptor agonists. The compilation of data suggests that NT receptor agonists may represent a novel class of antipsychotic drugs for the treatment of schizophrenia.
Keywords: Antipsychotic drug, peptide, neuromedin N, xenin, schizophrenia
CNS & Neurological Disorders - Drug Targets
Title: Novel Treatments of Schizophrenia: Targeting the Neurotensin System
Volume: 5 Issue: 2
Author(s): B. Kinkead and C. B. Nemeroff
Affiliation:
Keywords: Antipsychotic drug, peptide, neuromedin N, xenin, schizophrenia
Abstract: Evidence implicating neural circuits that utilize the neuropeptide transmitter neurotensin (NT) in the pathophysiology of schizophrenia and in the mechanism of action of antipsychotic drugs has previously been reviewed. The majority of evidence, taken together, supports the development of NT receptor agonists as novel antipsychotic drugs. This review comprehensively describes the NT receptor subtypes, discusses the development of NT receptor agonists and the behavioral effects of currently available NT receptor agonists. The compilation of data suggests that NT receptor agonists may represent a novel class of antipsychotic drugs for the treatment of schizophrenia.
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Kinkead B. and Nemeroff B. C., Novel Treatments of Schizophrenia: Targeting the Neurotensin System, CNS & Neurological Disorders - Drug Targets 2006; 5 (2) . https://dx.doi.org/10.2174/187152706776359655
DOI https://dx.doi.org/10.2174/187152706776359655 |
Print ISSN 1871-5273 |
Publisher Name Bentham Science Publisher |
Online ISSN 1996-3181 |
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