Abstract
Several strategies used in the rational design and synthesis of fluorinated compounds as potential therapeutic agents are reviewed. Applications of fluorine substitution in empirical SAR studies for lead development also are discussed, along with the implications with respect to fluorine target interactions that can be derived from biological activities.
Keywords: fluorine substitution, 5-Fluorouracil (5-FU), T138067, Hydrolytic stability, cholesterol acyl transferas, monofluorination
Current Topics in Medicinal Chemistry
Title: Selective Fluorination in Drug Design and Development: An Overview of Biochemical Rationales
Volume: 6 Issue: 14
Author(s): Kenneth L. Kirk
Affiliation:
Keywords: fluorine substitution, 5-Fluorouracil (5-FU), T138067, Hydrolytic stability, cholesterol acyl transferas, monofluorination
Abstract: Several strategies used in the rational design and synthesis of fluorinated compounds as potential therapeutic agents are reviewed. Applications of fluorine substitution in empirical SAR studies for lead development also are discussed, along with the implications with respect to fluorine target interactions that can be derived from biological activities.
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Cite this article as:
Kirk L. Kenneth, Selective Fluorination in Drug Design and Development: An Overview of Biochemical Rationales, Current Topics in Medicinal Chemistry 2006; 6 (14) . https://dx.doi.org/10.2174/156802606777951073
DOI https://dx.doi.org/10.2174/156802606777951073 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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