Abstract
A series of eight N-(disubstitutedbenzoyl)isoniazid derivatives have been synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv using the alamar blue susceptibility test and the activity expressed as the minimum inhibitory concentration (MIC) in μg/mL. Compounds 15 and 16 exhibited a significant activity (0.5 μg/mL) when compared with first line drugs such as isoniazid (INH) and rifampicin (RIP) and could be a good starting point to develop new lead compounds in the fight against multi-drug resistant tuberculosis.
Keywords: Isoniazid, analogs, anti-tubercular activity
Letters in Drug Design & Discovery
Title: Synthesis and In Vitro Anti-Tubercular Activity of a Series of N- (Disubstitutedbenzoyl)Isoniazid Derivatives
Volume: 3 Issue: 6
Author(s): Ivan Neves Junior, Maria C.S. Lourenco, Guilherme de B.P. de Miranda, Thatyana R.A. Vasconcelos, Karla C. Pais, Jose dos P. de A. Junior, M. S.V. Wardell, James L. Wardell and V. N. de Souza
Affiliation:
Keywords: Isoniazid, analogs, anti-tubercular activity
Abstract: A series of eight N-(disubstitutedbenzoyl)isoniazid derivatives have been synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv using the alamar blue susceptibility test and the activity expressed as the minimum inhibitory concentration (MIC) in μg/mL. Compounds 15 and 16 exhibited a significant activity (0.5 μg/mL) when compared with first line drugs such as isoniazid (INH) and rifampicin (RIP) and could be a good starting point to develop new lead compounds in the fight against multi-drug resistant tuberculosis.
Export Options
About this article
Cite this article as:
Neves Junior Ivan, Lourenco C.S. Maria, de Miranda de B.P. Guilherme, Vasconcelos R.A. Thatyana, Pais C. Karla, dos P. de A. Junior Jose, Wardell S.V. M., Wardell L. James and de Souza N. V., Synthesis and In Vitro Anti-Tubercular Activity of a Series of N- (Disubstitutedbenzoyl)Isoniazid Derivatives, Letters in Drug Design & Discovery 2006; 3 (6) . https://dx.doi.org/10.2174/157018006777805549
DOI https://dx.doi.org/10.2174/157018006777805549 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Anti-Tuberculosis Drug Induced Hepatotoxicity and Genetic Polymorphisms in Drug-metabolizing Genes
Current Pharmacogenomics A Novel Method for Preparation of Linezolid, (S)-N-((3-(3-Fluoro-4- Morpholinophenyl)-2-Oxo-5-Oxazolidinyl) Methyl) Acetamide
Letters in Organic Chemistry Antimicrobial and Antifungal Properties of Leaves to Root Extracts and Saponin Fractions of <i>Chlorophytum borivilianum</i>
Current Bioactive Compounds Genetically Modified Viruses Vaccines by Design
Current Pharmaceutical Biotechnology Cytokine Therapeutics for the Treatment of Sepsis: Why has Nothing Worked?
Current Pharmaceutical Design p53-Induced Apoptosis and Inhibitors of p53
Current Medicinal Chemistry Heart Failure in Sub-Saharan Africa
Current Cardiology Reviews Biologics for the Treatment of Juvenile Idiopathic Arthritis
Current Medicinal Chemistry The Role of Cnidaria in Drug Discovery. A Review on CNS Implications and New Perspectives
Recent Patents on CNS Drug Discovery (Discontinued) Editorial
Current Drug Targets - Infectious Disorders Targeted Delivery of Anti-Inflammatory Agents to Tumors
Current Pharmaceutical Design Molecules of Infectious Agents as Immunomodulatory Drugs
Current Topics in Medicinal Chemistry Metals and Metal Derivatives in Medicine
Mini-Reviews in Medicinal Chemistry MIF and CD74 - Suitability as Clinical Biomarkers
Mini-Reviews in Medicinal Chemistry Antibacterial Activity and Structure-Activity Relationship Studies of 4- aryl/alkyl-1-(diphenylacetyl)thiosemicarbazides
Letters in Drug Design & Discovery Anti-Oxidative Stress and Beyond: Multiple Functions of the Protein Glutathionylation
Protein & Peptide Letters Prevalence of Dilated Cardiomyopathy in HIV-Infected African Patients Not Receiving HAART: A Multicenter, Observational, Prospective, Cohort Study in Rwanda
Current HIV Research Novel Pharmacologic Approaches to the Management of Sepsis: Targeting the Host Inflammatory Response
Recent Patents on Inflammation & Allergy Drug Discovery Understanding the Molecular Mechanisms of Rifaximin in the Treatment of Gastrointestinal Disorders – A Focus on the Modulation of Host Tissue Function
Mini-Reviews in Medicinal Chemistry The Role of Infections in the Pathogenesis of Autoimmune Diseases
Current Drug Targets - Inflammation & Allergy