The Pharmacology of Aminoadamantane Nitrates

Title: The Pharmacology of Aminoadamantane Nitrates

Volume: 3 Issue: 3

Author(s): Yuqiang Wang, Jerry Eu, Mark Washburn, Tong Gong, H.-S. Vincent Chen, W. Larrick James, Stuart A. Lipton, Jonathan S. Stamler, Gregory T. Went and Seth Porter

Affiliation:

Keywords: NMDA receptor, S-nitrosothiol, Electrophysiology, memantine-binding domain, open-channel block

Abstract: Memantine, an aminodamantane, has recently been approved to treat moderate-to-severe Alzheimers disease in the US after over 20 years on the market in Europe for treatment of Parkinsons disease. The unique properties of Memantine allow for its selective inhibition of abnormally active NMDA receptor channels while preserving normal glutamate activity and healthy neuronal function. Recently, it has been shown that compounds such as nitroglycerin, used for years for ischemic coronary disease, can also regulate the NMDA receptor channel. Novel compounds have been synthesized in an attempt to combine these activities, in an attempt to synergistically improve upon the activities of both nitrates and aminoadamantanes. We have subjected these compounds to several laboratory tests to compare their ability to affect the function of the NMDA receptor and to dilate blood vessels. These tests provide an initial indication of which of the compounds may have enhanced activity relative to memantine. The results also provide guidance for the synthesis of additional compounds that are likely to have the properties that are being sought.

Cite this article as:

Wang Yuqiang, Eu Jerry, Washburn Mark, Gong Tong, Vincent Chen H.-S., Larrick James W., Lipton A. Stuart, Stamler S. Jonathan, Went T. Gregory and Porter Seth, The Pharmacology of Aminoadamantane Nitrates, Current Alzheimer Research 2006; 3 (3) . https://dx.doi.org/10.2174/156720506777632808