Abstract
There are two types of bacterial communication systems, those in which the signal produced by bacteria isdirected only at other organisms, and those where the signal is detected by others and self. The latter is involved inadaptation to the environment. The adaptation signals are autoinducers, the response is population density-dependent andhas been termed "quorum sensing". Our current knowledge of bacterial signaling systems indicates that Gram positivebacteria use small peptides for both types of signaling, whereas Gram negative organisms use homoserine lactones asautoinducers. Gram- negative bacteria internalize the signals which act upon an intracellular receptor. Gram-positivebacteria use the signals as ligands for an extracellular receptor of a two-component signaling system. Inhibitors of quorumsensing compounds for both Gram positive and Gram negative bacteria are being explored. Signal inhibitors could bepotentially effective in impeding biofilm formation, which might prolong the utility of the currently available antibioticsin this era of antibiotic resistance. In this review, we will explore both bacteria-host and bacteria-bacteria communicationsystems, with an emphasis on inhibitors of these systems both natural and synthetic.
Mini-Reviews in Medicinal Chemistry
Title: Chemical Communication-Do We Have a Quorum?
Volume: 6 Issue: 7
Author(s): Monika I. Konaklieva and Balbina J. Plotkin
Affiliation:
Abstract: There are two types of bacterial communication systems, those in which the signal produced by bacteria isdirected only at other organisms, and those where the signal is detected by others and self. The latter is involved inadaptation to the environment. The adaptation signals are autoinducers, the response is population density-dependent andhas been termed "quorum sensing". Our current knowledge of bacterial signaling systems indicates that Gram positivebacteria use small peptides for both types of signaling, whereas Gram negative organisms use homoserine lactones asautoinducers. Gram- negative bacteria internalize the signals which act upon an intracellular receptor. Gram-positivebacteria use the signals as ligands for an extracellular receptor of a two-component signaling system. Inhibitors of quorumsensing compounds for both Gram positive and Gram negative bacteria are being explored. Signal inhibitors could bepotentially effective in impeding biofilm formation, which might prolong the utility of the currently available antibioticsin this era of antibiotic resistance. In this review, we will explore both bacteria-host and bacteria-bacteria communicationsystems, with an emphasis on inhibitors of these systems both natural and synthetic.
Export Options
About this article
Cite this article as:
Konaklieva I. Monika and Plotkin J. Balbina, Chemical Communication-Do We Have a Quorum?, Mini-Reviews in Medicinal Chemistry 2006; 6 (7) . https://dx.doi.org/10.2174/138955706777698589
DOI https://dx.doi.org/10.2174/138955706777698589 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
Call for Papers in Thematic Issues
Bioprospecting of Natural Products as Sources of New Multitarget Therapies
According to the Convention on Biological Diversity, bioprospecting is the exploration of biodiversity and indigenous knowledge to develop commercially valuable products for pharmaceutical and other applications. Bioprospecting involves searching for useful organic compounds in plants, fungi, marine organisms, and microorganisms. Natural products traditionally constituted the primary source of more than ...read more
Computational Frontiers in Medicinal Chemistry
The thematic issue "Computational Frontiers in Medicinal Chemistry" provides a robust platform for delving into state-of-the-art computational methodologies and technologies that significantly propel advancements in medicinal chemistry. This edition seeks to amalgamate top-tier reviews spotlighting the latest trends and breakthroughs in the fusion of computational approaches, including artificial intelligence (AI) ...read more
Natural Products and Dietary Supplements in Alleviation of Metabolic, Cardiovascular, and Neurological Disorders
Metabolic disorders like diabetes, obesity, inflammation, oxidative stress, cancer etc, cardiovascular disorders like angina, myocardial infarction, congestive heart failure etc as well as neurological disorders like Alzheimer?s, Parkinson?s, Epilepsy, Depression, etc are the global burden. They covered the major segment of the diseases and disorders from which the human community ...read more
Natural Products in Drug Discovery
Natural products have always been one of the important ways of drug discovery due to their novel skeleton and diverse functional group characteristics. According to statistics, between 1981 and 2019, the FDA approved a total of 1,394 small molecule drugs for marketing, of which 930 marketed drugs originated from the ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Generation of Mesenchymal Stem Cells by Blood Cell Reprogramming
Current Stem Cell Research & Therapy Development of New Drugs that Act Through Membrane Receptors and Involve an Action of Inverse Agonism
Recent Patents on CNS Drug Discovery (Discontinued) Editorial {Hot topic: QSPR Models for Computer-Aided Drug Design in Microbiology, Parasitology, and Pharmacology (Guest Editor: Humberto Gonzalez-Diaz)]
Current Computer-Aided Drug Design Novel Anti-inflammatory Drugs from Marine Microbes
The Natural Products Journal Relevance of Aβ 1-42 Intrahippocampal Injection as An Animal Model of Inflamed Alzheimers Disease Brain
Current Alzheimer Research Influence of Different Substituents on Anion Binding Ability in Aromatic Hydroxyl Group Derivatives: Experiment and Theory
Current Analytical Chemistry Proteomic Strategies for the Analysis of Carbonyl Groups on Proteins
Current Protein & Peptide Science Neurochemicals Involved in Medullary Control of Common Carotid Blood Flow
Current Neuropharmacology Automated Parallel Solid-Phase Synthesis of Non-Peptide CCR1 Receptor Antagonists
Combinatorial Chemistry & High Throughput Screening Targeting the Chemokine Receptor CXCR3 and Its Ligand CXCL10 in the Central Nervous System: Potential Therapy for Inflammatory Demyelinating Disease?
Current Neurovascular Research Metal Triflates: Efficient Catalysts for Oxa-Pictet-Spengler Reaction
Letters in Organic Chemistry Clinical Application of PET Myocardial Perfusion Imaging
Current Medical Imaging Sudden Death and Ventricular Preexcitation: Is it Necessary to Treat the Asymptomatic Patients?
Current Pharmaceutical Design Fluorescent Probes for the Detection of Hydrogen Peroxide in Biological Systems
Current Organic Chemistry Brain Nitric Oxide and Its Dual Role in Neurodegeneration / Neuroprotection: Understanding Molecular Mechanisms to Devise Drug Approaches
Current Medicinal Chemistry Cognitive Consequences of a Sustained Monocyte Type 1 IFN Response in HIV-1 Infection
Current HIV Research Influence of Adrenalectomy on Protective Effects of Urocortin I, a Corticotropin-Releasing Factor, Against Indomethacin-Induced Enteropathy in Rats
Current Neuropharmacology Principal Component Structuring of the Non-REM Sleep EEG Spectrum in Older Adults Yields Age-Related Changes in the Sleep and Wake Drives
Current Aging Science Molecular Links Between Endothelial Dysfunction and Neurodegeneration in Alzheimer's Disease
Current Alzheimer Research Addressing Crises in Teenage Pregnancy
Adolescent Psychiatry