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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Structural Properties of the NMDA Receptor and the Design of Neuroprotective Therapies

Author(s): A. M. Gerber and M. L. Vallano

Volume 6, Issue 7, 2006

Page: [805 - 815] Pages: 11

DOI: 10.2174/138955706777698651

Price: $65

Abstract

NMDA receptors are linked to neuronal loss in stroke and neurodegeneration because their activation can triggerexcitotoxic Ca2+ dysregulation. Accordingly, NMDA receptor antagonists are neuroprotective, providing a rationale fortheir clinical application. However, side effects often outweigh benefits. Herein we highlight structural properties inreceptors that are used in drug development.

Keywords: Glutamate, excitotoxicity, NMDA receptor, therapeutics, neurodegeneration, drug design


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