Abstract
In the last years scientific interest in homocysteine is growing. Homocysteine is a risk factor for cardiovascular morbidity and mortality in the general population with normal renal function. The relationship between homocysteine and cardiovascular disease in patients with renal failure is unclear. This review shows up homocysteine metabolism and its interactions with drugs and diseases, summarizes homocysteines toxic effects and the results of clinical studies about the effects of homocysteine-lowering therapy on hard endpoints like cardiovascular morbidity and mortality, and describes which kind of treatment can reduce homocysteine in dialysis patients.
Keywords: Homocysteine, folic acid, vitamin B, cardiovascular disease
Letters in Drug Design & Discovery
Title: Homocysteine and Folate Therapy in Dialysis Patients
Volume: 3 Issue: 5
Author(s): Marco Righetti
Affiliation:
Keywords: Homocysteine, folic acid, vitamin B, cardiovascular disease
Abstract: In the last years scientific interest in homocysteine is growing. Homocysteine is a risk factor for cardiovascular morbidity and mortality in the general population with normal renal function. The relationship between homocysteine and cardiovascular disease in patients with renal failure is unclear. This review shows up homocysteine metabolism and its interactions with drugs and diseases, summarizes homocysteines toxic effects and the results of clinical studies about the effects of homocysteine-lowering therapy on hard endpoints like cardiovascular morbidity and mortality, and describes which kind of treatment can reduce homocysteine in dialysis patients.
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Cite this article as:
Righetti Marco, Homocysteine and Folate Therapy in Dialysis Patients, Letters in Drug Design & Discovery 2006; 3 (5) . https://dx.doi.org/10.2174/157018006777574140
DOI https://dx.doi.org/10.2174/157018006777574140 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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