Cytotoxic and COX-2 Inhibition Properties of Hydroxycinnamic Derivatives

Title: Cytotoxic and COX-2 Inhibition Properties of Hydroxycinnamic Derivatives

Volume: 3 Issue: 5

Author(s): M. Paula M. Marques, Fernanda Borges, Joana Sousa, Rita Calheiros, Jorge Garrido, Alexandra Gaspar, Carmen Diniz and Paula Fresco

Affiliation:

Keywords: Hydroxycinnamic derivatives, anti-inflammatory, COX-2, anticancer, mammary gland adenocarcinoma cells

Abstract: The anticancer (cytotoxicity against human mammary gland adenocarcinoma cells) and antiinflammatory properties (COX-2 inhibition) of the hydroxycinnamic derivatives trans-3-(3,4,5- trihydroxyphenyl)-2-propenoic acid, trans-ethyl(3,4,5-trihydroxyphenyl)-2-propenoate and diethyl 2-(3,4,5- trihydroxy-phenylmethylene)malonate were screened. Data point out a putative correlation between antiinflammatory and anticancer properties and suggest hydroxycinnamic derivatives as promising lead compounds for the development of anti-inflammatory/chemopreventive agents.

Cite this article as:

M. Marques M. Paula, Borges Fernanda, Sousa Joana, Calheiros Rita, Garrido Jorge, Gaspar Alexandra, Diniz Carmen and Fresco Paula, Cytotoxic and COX-2 Inhibition Properties of Hydroxycinnamic Derivatives, Letters in Drug Design & Discovery 2006; 3 (5) . https://dx.doi.org/10.2174/157018006777574212