Target Structure-based Modeling of the Glutamate Transporter Pharmacophore

A.      Simon; A.      Bencsura; J.      Kardos

Author(s): A. Simon, A. Bencsura and J. Kardos

Volume 3, Issue 5, 2006

Page: [293 - 297] Pages: 5

DOI: 10.2174/157018006777574230

Price: $65

Abstract

Comparison of binding interactions of a bacterial Glu transporter homologue and the extracellular binding domain of metabotropic Glu receptor subtype (mGlu1) showed Glu adopting bent and extended conformations in Glu transporter and mGlu1, respectively.

Keywords: Glutamate transporter, metabotropic Glu receptor subtype 1, docking and molecular dynamics, glutamate, L-trans-2, 4-PDC, GABA

« Previous Next »

Rights & Permissions Print Cite

Letters in Drug Design & Discovery

Title: Target Structure-based Modeling of the Glutamate Transporter Pharmacophore

Volume: 3 Issue: 5

Author(s): A. Simon, A. Bencsura and J. Kardos

Affiliation:

Keywords: Glutamate transporter, metabotropic Glu receptor subtype 1, docking and molecular dynamics, glutamate, L-trans-2, 4-PDC, GABA

Abstract: Comparison of binding interactions of a bacterial Glu transporter homologue and the extracellular binding domain of metabotropic Glu receptor subtype (mGlu1) showed Glu adopting bent and extended conformations in Glu transporter and mGlu1, respectively.

Export Options

Export File:

RIS (for EndNote, Reference Manager, ProCite)

BibTeX

Text

Content:

Citation Only

Citation and Abstract

About this article

Cite this article as:

Simon A., Bencsura A. and Kardos J., Target Structure-based Modeling of the Glutamate Transporter Pharmacophore, Letters in Drug Design & Discovery 2006; 3 (5) . https://dx.doi.org/10.2174/157018006777574230