Antimicrobial Properties of Organosulfur Anti-Infectives: A Review of Patent Literature 1999-2005

Title: Antimicrobial Properties of Organosulfur Anti-Infectives: A Review of Patent Literature 1999-2005

Volume: 1 Issue: 2

Author(s): Monika I. Konaklieva and Balbina J. Plotkin

Affiliation:

Keywords: Organosulfur compounds, thiols, sulfides, thiosulfinates, antimicrobials, Allicin, thioethers, metallo-β lactamases

Abstract: The number of organosulfur compounds being patented has been growing. A wide variety of these organosulfur compounds, whether naturally occurring or synthetic, exhibit antibacterial properties. Mechanistically, organosulfur groups can act as metal chelators, powerful nucleophiles or electrophiles depending on the local environment in which a given reaction occurs. In this review of the patent literature from 1999-2005, the reliance of these compounds on the reaction of the sulfur moiety with its biological target(s) will be discussed with regards to activity, specificity, and antimicrobial spectrum.

Cite this article as:

Konaklieva I. Monika and Plotkin J. Balbina, Antimicrobial Properties of Organosulfur Anti-Infectives: A Review of Patent Literature 1999-2005, Recent Patents on Anti-Infective Drug Discovery 2006; 1 (2) . https://dx.doi.org/10.2174/157489106777452683