Abstract
Based on recent research neuroinflammation is more than just a pathological mechanism in neurodegenerative diseases. As representatives for the cytokine family we will review the functions of Interleukin-6 and Tumor Necorosis Factor with respect to their role in neuroprotection and neurodegeneration. Both cytokines have been found to be strongly upregulated during diseases such as Alzheimers disease, stroke or Parkinsons syndrome. By comparing signaling function of these cytokines during health and disease it becomes clear that the role of cytokine mediated tissue modulation depends very much on the molecular and cellular state of nerve cells e.g. physiological vs. pathological. Finally, we will discuss the possibilities of using cytokine activated pathways as a potential targets for therapeutic avenues.
Keywords: Tumor Necrosis Factor, Interleukin-6, Nuclear Factor kappa B, Protein Kinase B/Akt, gp130, STAT
Current Signal Transduction Therapy
Title: Life and Death of Nerve Cells: Therapeutic Cytokine Signaling Pathways
Volume: 1 Issue: 2
Author(s): Ulrich L.M. Eisel, Knut Biber and Paul G.M. Luiten
Affiliation:
Keywords: Tumor Necrosis Factor, Interleukin-6, Nuclear Factor kappa B, Protein Kinase B/Akt, gp130, STAT
Abstract: Based on recent research neuroinflammation is more than just a pathological mechanism in neurodegenerative diseases. As representatives for the cytokine family we will review the functions of Interleukin-6 and Tumor Necorosis Factor with respect to their role in neuroprotection and neurodegeneration. Both cytokines have been found to be strongly upregulated during diseases such as Alzheimers disease, stroke or Parkinsons syndrome. By comparing signaling function of these cytokines during health and disease it becomes clear that the role of cytokine mediated tissue modulation depends very much on the molecular and cellular state of nerve cells e.g. physiological vs. pathological. Finally, we will discuss the possibilities of using cytokine activated pathways as a potential targets for therapeutic avenues.
Export Options
About this article
Cite this article as:
Eisel L.M. Ulrich, Biber Knut and Luiten G.M. Paul, Life and Death of Nerve Cells: Therapeutic Cytokine Signaling Pathways, Current Signal Transduction Therapy 2006; 1 (2) . https://dx.doi.org/10.2174/157436206777012057
DOI https://dx.doi.org/10.2174/157436206777012057 |
Print ISSN 1574-3624 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-389X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Effects of Vitamin A Deficiency and Opioids on Parvalbumin + Interneurons in the Hippocampus of the HIV-1 Transgenic Rat
Current HIV Research Inflammatory Process in Parkinsons Disease: Role for Cytokines
Current Pharmaceutical Design Cefepime-Induced Neurotoxicity
Central Nervous System Agents in Medicinal Chemistry Role of Psychiatrists in the Diagnosis and Management of Alzheimer's Disease “Revisited”: A Review and Clinical Opinion
Current Psychiatry Reviews Immunomodulation in Trichinellosis: Does Trichinella Really Escape the Host Immune System?
Endocrine, Metabolic & Immune Disorders - Drug Targets Neurotrophic Actions of Mood-Stabilizers: A Recent Research Discovery and its Potential Clinical Applications
Current Psychiatry Reviews The Use of Lectins as Tools to Combat SARS-CoV-2
Current Pharmaceutical Design Polymer-based Drug Delivery Systems Applied to Insects Repellents Devices: A Review
Current Drug Delivery Synthesis, Molecular Docking and Evaluation of 3-{4-[2-amino-4-(substitutedphenyl)-2H-[1, 3] oxazin/thiazin-6-yl} 2-phenyl-3H-quinazolin-4-one Derivatives for their Anticonvulsant Activity
Central Nervous System Agents in Medicinal Chemistry Mechanisms of HIV-1 Tat Neurotoxicity via CDK5 Translocation and Hyper-Activation: Role in HIV-Associated Neurocognitive Disorders
Current HIV Research Dietary Antioxidants: Immunity and Host Defense
Current Topics in Medicinal Chemistry Capillary Electrophoresis Interfaced with a Mass Spectrometer (CE-MS): Technical Considerations and Applicability for Biomarker Studies in Animals
Current Protein & Peptide Science Cellular and Biochemical Actions of Melatonin which Protect Against Free Radicals: Role in Neurodegenerative Disorders
Current Neuropharmacology The Cytokine Network in HIV Infection
Current Molecular Medicine Pediatric Epilepsy Surgery: Neuropsychological and Psychosocial Outcomes
Current Pediatric Reviews Immune Cell Entry to Central Nervous System - Current Understanding and Prospective Therapeutic Targets
Endocrine, Metabolic & Immune Disorders - Drug Targets mRNA as a Versatile Tool for Exogenous Protein Expression
Current Gene Therapy A Highlight on Lipid Based Nanocarriers for Transcutaneous Immunization
Current Pharmaceutical Biotechnology Novel Genetic and Peptide-Based Strategies Targeting the Bcl-2 Family, an Update
Recent Patents on DNA & Gene Sequences Hendra and Nipah Infection: Pathology, Models and Potential Therapies
Infectious Disorders - Drug Targets