Abstract
Transgenic mice models for Alzheimers disease (AD) are essential to the understanding of disease pathophysiology, develop robust behavioral models and predict outcomes from pharmacological interventions. In the last 10 years, numerous mice models have been developed particularly focusing on the amyloid precursor protein-processing pathway and Tau pathology since brain amyloid deposits and Tau tangles are some of the primary neuropathological consequences of AD. Current views on the amyloid hypothesis and mice models relating to the role of soluble Aβ oligomers and intracellular Aβ in AD pathophysiology will be reviewed. Several novel transgenic mice models that have recently been developed and their potential impact on understanding disease pathogenesis will also be summarized.
Keywords: Alzheimer's, transgenic, APP, Tau, Abeta, amyloid, oligomer, intraneuronal, neurodegeneration, mutation
Current Topics in Medicinal Chemistry
Title: Genetically Modified Mice Models for Alzheimers Disease
Volume: 6 Issue: 6
Author(s): Sethu Sankaranarayanan
Affiliation:
Keywords: Alzheimer's, transgenic, APP, Tau, Abeta, amyloid, oligomer, intraneuronal, neurodegeneration, mutation
Abstract: Transgenic mice models for Alzheimers disease (AD) are essential to the understanding of disease pathophysiology, develop robust behavioral models and predict outcomes from pharmacological interventions. In the last 10 years, numerous mice models have been developed particularly focusing on the amyloid precursor protein-processing pathway and Tau pathology since brain amyloid deposits and Tau tangles are some of the primary neuropathological consequences of AD. Current views on the amyloid hypothesis and mice models relating to the role of soluble Aβ oligomers and intracellular Aβ in AD pathophysiology will be reviewed. Several novel transgenic mice models that have recently been developed and their potential impact on understanding disease pathogenesis will also be summarized.
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Cite this article as:
Sankaranarayanan Sethu, Genetically Modified Mice Models for Alzheimers Disease, Current Topics in Medicinal Chemistry 2006; 6 (6) . https://dx.doi.org/10.2174/156802606776743020
DOI https://dx.doi.org/10.2174/156802606776743020 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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