Abstract
More recently, three novel purine nucleoside analogs, including clofarabine, nelarabine and immucillin H, have been introduced into clinical trials. These agents have different metabolic properties, novel mechanism of action, and are undergoing phase I-II clinical studies for the treatment of hematopoietic malignancies. Pharmacology and anticancer activity of PNA are the subjects of this review.
Keywords: Cladribine, fludarabine, pentostatin, clofarabine, nelarabine, immucillin H
Mini-Reviews in Medicinal Chemistry
Title: Pharmacological and Clinical Studies on Purine Nucleoside Analogs- New Anticancer Agents
Volume: 6 Issue: 5
Author(s): E. Lech-Maranda, A. Korycka and T. Robak
Affiliation:
Keywords: Cladribine, fludarabine, pentostatin, clofarabine, nelarabine, immucillin H
Abstract: More recently, three novel purine nucleoside analogs, including clofarabine, nelarabine and immucillin H, have been introduced into clinical trials. These agents have different metabolic properties, novel mechanism of action, and are undergoing phase I-II clinical studies for the treatment of hematopoietic malignancies. Pharmacology and anticancer activity of PNA are the subjects of this review.
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Cite this article as:
Lech-Maranda E., Korycka A. and Robak T., Pharmacological and Clinical Studies on Purine Nucleoside Analogs- New Anticancer Agents, Mini-Reviews in Medicinal Chemistry 2006; 6 (5) . https://dx.doi.org/10.2174/138955706776876212
DOI https://dx.doi.org/10.2174/138955706776876212 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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