Abstract
Hepatitis C virus represents a major global health problem, with approximately 3% of the world population infected. Immune-response modifiers represent the standard of care, given the lack of approved antiviral agents having direct activity against the viral proteins. Although in recent years, improvements in therapy have been attained by combined treatment with pegylated interferon and ribavirin, the discovery and development of next-generation small molecule and biologic agents is ongoing. Several of these newer therapeutics are focused on modulating Toll-like receptors, interferon-alpha signaling, and the pro-inflammatory cytokine balance. A comprehensive account of the lead compounds in development, the bioassays used for optimization of these immune response modifiers and their clinical status is presented.
Keywords: Imiquimod, isatoribine, cytosine-guanine oligonucleotides (CpG), immunomodulatory oligonucleotides (IMOs), toll-like receptors (TLR), inteferon (IFN)
Mini-Reviews in Medicinal Chemistry
Title: Small Molecule and Biologic Modulators of the Immune Response to Hepatitis C Virus
Volume: 6 Issue: 5
Author(s): M. L. Mbow, A. Eaton-Bassiri, W. G. Glass, A. M. Del Vecchio and R. T. Sarisky
Affiliation:
Keywords: Imiquimod, isatoribine, cytosine-guanine oligonucleotides (CpG), immunomodulatory oligonucleotides (IMOs), toll-like receptors (TLR), inteferon (IFN)
Abstract: Hepatitis C virus represents a major global health problem, with approximately 3% of the world population infected. Immune-response modifiers represent the standard of care, given the lack of approved antiviral agents having direct activity against the viral proteins. Although in recent years, improvements in therapy have been attained by combined treatment with pegylated interferon and ribavirin, the discovery and development of next-generation small molecule and biologic agents is ongoing. Several of these newer therapeutics are focused on modulating Toll-like receptors, interferon-alpha signaling, and the pro-inflammatory cytokine balance. A comprehensive account of the lead compounds in development, the bioassays used for optimization of these immune response modifiers and their clinical status is presented.
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Mbow L. M., Eaton-Bassiri A., Glass G. W., Del Vecchio M. A. and Sarisky T. R., Small Molecule and Biologic Modulators of the Immune Response to Hepatitis C Virus, Mini-Reviews in Medicinal Chemistry 2006; 6 (5) . https://dx.doi.org/10.2174/138955706776876195
DOI https://dx.doi.org/10.2174/138955706776876195 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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