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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Topical Imiquimod: Mechanism of Action and Clinical Applications

Author(s): David Vidal

Volume 6, Issue 5, 2006

Page: [499 - 503] Pages: 5

DOI: 10.2174/138955706776876131

Price: $65

Abstract

Imiquimod is a synthetic imidazoquinoline heterocyclic amine of 240.3 Da (C14H16N4). Imiquimod is a cytokine inducer and a modifier of the innate immune response, as well as acquired antiviral and antitumor immune responses. Imiquimod 5% cream has proven to be an effective treatment for external genital warts, superficial basal cell carcinoma, and actinic keratosis.

Keywords: Imiquimod, imidazoquinolone, immune response modifier, toll-like receptor, skin infection, skin cancer


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