Abstract
Systemic lupus erythematosus (SLE) is more severe in children than in adults, and often needs aggressive treatment. Classical (old ) therapies include mostly non-steroid anti-inflammatory drugs, hydroxychloroquine, corticosterois and cyclophosphamide. However, these two latter drugs can induce severe side effects. Recently, new drugs, especially Mycophenolate Mofetyl and anti-CD20 antibody, have been proved to be efficient and well tolerated in adult-onset SLE and may become mainstay therapeutic option for severe chidhood-onset lupus manifestations. Management of complications such as growth failure, osteoporosis, premature atherosclerosis and anti-phospholipid syndrome has also progressed within the last years. Beside these promising perspectives of treatment, psychological support, long-term follow-up and program of transition from the pediatric to the adult care unit remain essential.
Keywords: Hydroxychloroquine, NSAID, Cyclophosphamide, Mycophenolate Mofetil (MMF), Autologous Marrow Stem-Cell Transplantation, Osteoporosis
Current Pediatric Reviews
Title: Childhood Systemic Lupus Erythematosus: New and Old Treatments
Volume: 2 Issue: 2
Author(s): Brigitte Bader-Meunier and Elie Haddad
Affiliation:
Keywords: Hydroxychloroquine, NSAID, Cyclophosphamide, Mycophenolate Mofetil (MMF), Autologous Marrow Stem-Cell Transplantation, Osteoporosis
Abstract: Systemic lupus erythematosus (SLE) is more severe in children than in adults, and often needs aggressive treatment. Classical (old ) therapies include mostly non-steroid anti-inflammatory drugs, hydroxychloroquine, corticosterois and cyclophosphamide. However, these two latter drugs can induce severe side effects. Recently, new drugs, especially Mycophenolate Mofetyl and anti-CD20 antibody, have been proved to be efficient and well tolerated in adult-onset SLE and may become mainstay therapeutic option for severe chidhood-onset lupus manifestations. Management of complications such as growth failure, osteoporosis, premature atherosclerosis and anti-phospholipid syndrome has also progressed within the last years. Beside these promising perspectives of treatment, psychological support, long-term follow-up and program of transition from the pediatric to the adult care unit remain essential.
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Cite this article as:
Bader-Meunier Brigitte and Haddad Elie, Childhood Systemic Lupus Erythematosus: New and Old Treatments, Current Pediatric Reviews 2006; 2 (2) . https://dx.doi.org/10.2174/157339606776894630
DOI https://dx.doi.org/10.2174/157339606776894630 |
Print ISSN 1573-3963 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6336 |
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