Abstract
Hypoxia-ischemia is responsible for a high morbidity and mortality rate, both in infant and adult patients. In humans, the brain is immature from fetal to postnatal life, demonstrating more specific vulnerability than the adult one, induced by exposure at perinatal asphyxia. The extension and distribution of brain lesions depend to a large extent on the intensity and exposure to injury, the maturational stage, the affected brain region and the survival time of the patient. Different cellular events are developed in response to hypoxic-ischemic injury. These events have been related to the excitotoxicity (activation of glutamate receptors), energy failure (decrease in ATP levels), inflammatory cascade (delivery of inflammatory mediators), and gene and transcriptional activation.
Keywords: Hipoxia-Ischemia, Perinatal asphyxia, Brain damage, Excitotoxicity
Current Pediatric Reviews
Title: Cellular Mechanisms in Perinatal Hypoxic-Ischemic Brain Injury
Volume: 2 Issue: 2
Author(s): Enrique Hilario, Antonia Alvarez, Francisco J. Alvarez, Elena Gastiasoro and Adolf Valls-i-Soler
Affiliation:
Keywords: Hipoxia-Ischemia, Perinatal asphyxia, Brain damage, Excitotoxicity
Abstract: Hypoxia-ischemia is responsible for a high morbidity and mortality rate, both in infant and adult patients. In humans, the brain is immature from fetal to postnatal life, demonstrating more specific vulnerability than the adult one, induced by exposure at perinatal asphyxia. The extension and distribution of brain lesions depend to a large extent on the intensity and exposure to injury, the maturational stage, the affected brain region and the survival time of the patient. Different cellular events are developed in response to hypoxic-ischemic injury. These events have been related to the excitotoxicity (activation of glutamate receptors), energy failure (decrease in ATP levels), inflammatory cascade (delivery of inflammatory mediators), and gene and transcriptional activation.
Export Options
About this article
Cite this article as:
Hilario Enrique, Alvarez Antonia, Alvarez J. Francisco, Gastiasoro Elena and Valls-i-Soler Adolf, Cellular Mechanisms in Perinatal Hypoxic-Ischemic Brain Injury, Current Pediatric Reviews 2006; 2 (2) . https://dx.doi.org/10.2174/157339606776894667
DOI https://dx.doi.org/10.2174/157339606776894667 |
Print ISSN 1573-3963 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6336 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Special Issue on Stem Cells: An Introduction from the Guest Editor
Current Neurovascular Research Recent Advances in the Development of Selective Ligands for the Cannabinoid CB2 Receptor
Current Topics in Medicinal Chemistry Out-of-Hospital Cardiac Arrest –Optimal Management
Current Cardiology Reviews Pteridine Derivatives as Modulators of Oxidative Stress
Current Drug Metabolism Neurodegeneration in the Pathogenesis of Diabetic Retinopathy: Molecular Mechanisms and Therapeutic Implications
Current Medicinal Chemistry Medicinal Chemistry and Anti-Inflammatory Activity of Nitric Oxide-Releasing NSAI Drugs
Mini-Reviews in Medicinal Chemistry Amyloid Beta Peptide, 4-Hydroxynonenal and Apoptosis
Current Alzheimer Research Imaging of Cyclooxygenase-2 (COX-2) Expression: Potential Use in Diagnosis and Drug Evaluation
Current Pharmaceutical Design Renal Artery Stenosis: Current Perspectives on Imaging and Endovascular Management
Current Hypertension Reviews Genome-Wide Expression Analysis in Epilepsy: A Synthetic Review
Current Topics in Medicinal Chemistry Regenerative Potential of Stem Cell-derived Extracellular Vesicles in Spinal Cord Injury (SCI)
Current Stem Cell Research & Therapy The Anti-Inflammatory Role of Minocycline in Alzheimer´s Disease
Current Alzheimer Research Resveratrol: New Avenues for a Natural Compound in Neuroprotection
Current Pharmaceutical Design Bioconjugation of Polymers: A Novel Platform for Targeted Drug Delivery
Current Pharmaceutical Design Zolpidem Arousing Effect in Persistent Vegetative State Patients: Autonomic, EEG and Behavioral Assessment
Current Pharmaceutical Design Marine Depsipeptides as Promising Pharmacotherapeutic Agents
Current Protein & Peptide Science Neuro-Inflammatory Mechanisms in Developmental Disorders Associated with Intellectual Disability and Autism Spectrum Disorder: A Neuro- Immune Perspective
CNS & Neurological Disorders - Drug Targets Xuesaitong May Protect Against Ischemic Stroke by Modulating Microglial Phenotypes and Inhibiting Neuronal Cell Apoptosis via the STAT3 Signaling Pathway
CNS & Neurological Disorders - Drug Targets Recent Advances in Asthma Genetics and Antiasthma Therapy
Current Respiratory Medicine Reviews Vascular and Cellular Calcium in Normal and Hypertensive Pregnancy
Current Clinical Pharmacology