Abstract
Cardiovascular diseases are still the main cause of morbidity and mortality in the world. Anti-platelet drugs have found clinical application in the secondary prevention of vascular events including acute myocardial infarction, stroke and cardiovascular death. In the present review, we have developed sixteen quantitative structure-activity relationships (QSAR) for different sets of compounds that are X-phenols (I), Xcatechols (II ), caffeic acid amides (III), X-alcohols (IV), 1,4-naphthoquinones (V), tetrahydronaphthalenes (VI), phenoxyacetaldehyde guanylhydrazones (VII), pyrrolobenzylisoquinolines (VIII) and phosphonic acids (IX) with respect to their anti-platelet activities. QSAR results have shown that the anti-platelet activities of these compounds are largely dependent not only on their hydrophobicity, but also on the influence of their molar refractivity.
Keywords: Platelet aggregation inhibitors, Hydrophobicity, CMR, QSAR, Adenosine diphosphate (ADP), Arachidonic acid (AA), collagen (Col), Thrombin (Thr)
Mini-Reviews in Medicinal Chemistry
Title: A Classical QSAR Study on Some Platelet Aggregation Inhibitors
Volume: 6 Issue: 4
Author(s): Rajeshwar P. Verma
Affiliation:
Keywords: Platelet aggregation inhibitors, Hydrophobicity, CMR, QSAR, Adenosine diphosphate (ADP), Arachidonic acid (AA), collagen (Col), Thrombin (Thr)
Abstract: Cardiovascular diseases are still the main cause of morbidity and mortality in the world. Anti-platelet drugs have found clinical application in the secondary prevention of vascular events including acute myocardial infarction, stroke and cardiovascular death. In the present review, we have developed sixteen quantitative structure-activity relationships (QSAR) for different sets of compounds that are X-phenols (I), Xcatechols (II ), caffeic acid amides (III), X-alcohols (IV), 1,4-naphthoquinones (V), tetrahydronaphthalenes (VI), phenoxyacetaldehyde guanylhydrazones (VII), pyrrolobenzylisoquinolines (VIII) and phosphonic acids (IX) with respect to their anti-platelet activities. QSAR results have shown that the anti-platelet activities of these compounds are largely dependent not only on their hydrophobicity, but also on the influence of their molar refractivity.
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Cite this article as:
Verma P. Rajeshwar, A Classical QSAR Study on Some Platelet Aggregation Inhibitors, Mini-Reviews in Medicinal Chemistry 2006; 6 (4) . https://dx.doi.org/10.2174/138955706776361484
DOI https://dx.doi.org/10.2174/138955706776361484 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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